Comparison of the Influence of 45S5 and Cu-Containing 45S5 Bioactive Glass (BG) on the Biological Properties of Novel Polyhydroxyalkanoate (PHA)/BG Composites
by
Katharina Schuhladen 1
, Barbara Lukasiewicz 2, Pooja Basnett 2, Ipsita Roy 3,* and Aldo R. Boccaccini 1,*
Katharina Schuhladen 1, Barbara Lukasiewicz 2, Pooja Basnett 2, Ipsita Roy 3,* and Aldo R. Boccaccini 1,*
1
Department of Materials Science and Engineering, Institute of Biomaterials, University of Erlangen-Nuremberg, 91058 Erlangen, Germany
2
Applied Biotechnology Research Group, School of Life Sciences, College of Liberal Arts and Sciences, University of Westminster, London W1W 6UW, UK
3
Department of Material Science and Engineering, Faculty of Engineering, University of Sheffield, Mappin Street, Sheffield S1 3JD, UK
*
Authors to whom correspondence should be addressed.
Materials 2020, 13(11), 2607; https://doi.org/10.3390/ma13112607
Received: 9 May 2020 / Revised: 30 May 2020 / Accepted: 5 June 2020 / Published: 8 June 2020
(This article belongs to the Special Issue Polymer-Based Biomaterials and Tissue Engineering)
Polyhydroxyalkanoates (PHAs), due to their biodegradable and biocompatible nature and their ability to be formed in complex structures, are excellent candidates for fabricating scaffolds used in tissue engineering. By introducing inorganic compounds, such as bioactive glasses (BGs), the bioactive properties of PHAs can be further improved. In addition to their outstanding bioactivity, BGs can be additionally doped with biological ions, which in turn extend the functionality of the BG-PHA composite. Here, different PHAs were combined with 45S5 BG, which was additionally doped with copper in order to introduce antibacterial and angiogenic properties. The resulting composite was used to produce scaffolds by the salt leaching technique. By performing indirect cell biology tests using stromal cells, a dose-depending effect of the dissolution products released from the BG-PHA scaffolds could be found. In low concentrations, no toxic effect was found. Moreover, in higher concentrations, a minor reduction of cell viability combined with a major increase in VEGF release was measured. This result indicates that the fabricated composite scaffolds are suitable candidates for applications in soft and hard tissue engineering. However, more in-depth studies are necessary to fully understand the release kinetics and the resulting long-term effects of the BG-PHA composites.
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Keywords:
bioactive glass; copper; polyhydroxyalkanoates; tissue engineering; scaffolds
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MDPI and ACS Style
Schuhladen, K.; Lukasiewicz, B.; Basnett, P.; Roy, I.; Boccaccini, A.R. Comparison of the Influence of 45S5 and Cu-Containing 45S5 Bioactive Glass (BG) on the Biological Properties of Novel Polyhydroxyalkanoate (PHA)/BG Composites. Materials 2020, 13, 2607.
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