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Preparation and In Vitro Release of Total Alkaloids from Alstonia Scholaris Leaves Loaded mPEG-PLA Microspheres

1
National and Local Joint Engineering Research Center for Green Preparation Technology of Biobased Materials, Yunnan Minzu University, Kunming 650500, China
2
National and Local Joint Engineering Laboratory for Synthesis Technology of High Performance Polymer, Jilin University, Changchun 130012, China
*
Authors to whom correspondence should be addressed.
Materials 2019, 12(9), 1457; https://doi.org/10.3390/ma12091457
Received: 3 April 2019 / Revised: 26 April 2019 / Accepted: 28 April 2019 / Published: 6 May 2019
(This article belongs to the Special Issue Advanced Materials in Drug Release and Drug Delivery Systems)
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Abstract

Total alkaloids of Alstonia scholaris leaves (ASAs) are extracted from the lamp leaves, which have positive anti-inflammatory activity and remarkable effects in treating bronchitis. Due to its short half-life, we used a degradable mPEG-PLA to physically encapsulate the total alkali of the lamp stage, and prepared a sustained-release microsphere by double-emulsion method. The ASAs-loaded mPEG10000-PLA microspheres were screened for better performance by testing the morphology, average particle size, embedding rate and drug loading of different molecular weight mPEG-PLA microspheres, which can stably and continuously release for 15 days at 37 °C. The results of cytotoxicity and blood compatibility indicated that the drug-loaded microspheres have beneficial biocompatibility. Animal experiments showed that the drug-loaded microspheres had a beneficial anti-inflammatory effect. These results all indicated that mPEG-PLA is a controlled release carrier material suitable for ASAs. View Full-Text
Keywords: total alkaloids from Alstonia scholaris leaves; mPEG-PLA; microspheres; drug release; biocompatibility total alkaloids from Alstonia scholaris leaves; mPEG-PLA; microspheres; drug release; biocompatibility
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Zheng, X.; Li, H.; He, Y.; Yuan, M.; Shen, M.; Yang, R.; Jiang, N.; Yuan, M.; Yang, C. Preparation and In Vitro Release of Total Alkaloids from Alstonia Scholaris Leaves Loaded mPEG-PLA Microspheres. Materials 2019, 12, 1457.

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