Preparation and In Vitro Release of Total Alkaloids from Alstonia Scholaris Leaves Loaded mPEG-PLA Microspheres
AbstractTotal alkaloids of Alstonia scholaris leaves (ASAs) are extracted from the lamp leaves, which have positive anti-inflammatory activity and remarkable effects in treating bronchitis. Due to its short half-life, we used a degradable mPEG-PLA to physically encapsulate the total alkali of the lamp stage, and prepared a sustained-release microsphere by double-emulsion method. The ASAs-loaded mPEG10000-PLA microspheres were screened for better performance by testing the morphology, average particle size, embedding rate and drug loading of different molecular weight mPEG-PLA microspheres, which can stably and continuously release for 15 days at 37 °C. The results of cytotoxicity and blood compatibility indicated that the drug-loaded microspheres have beneficial biocompatibility. Animal experiments showed that the drug-loaded microspheres had a beneficial anti-inflammatory effect. These results all indicated that mPEG-PLA is a controlled release carrier material suitable for ASAs. View Full-Text
Share & Cite This Article
Zheng, X.; Li, H.; He, Y.; Yuan, M.; Shen, M.; Yang, R.; Jiang, N.; Yuan, M.; Yang, C. Preparation and In Vitro Release of Total Alkaloids from Alstonia Scholaris Leaves Loaded mPEG-PLA Microspheres. Materials 2019, 12, 1457.
Zheng X, Li H, He Y, Yuan M, Shen M, Yang R, Jiang N, Yuan M, Yang C. Preparation and In Vitro Release of Total Alkaloids from Alstonia Scholaris Leaves Loaded mPEG-PLA Microspheres. Materials. 2019; 12(9):1457.Chicago/Turabian Style
Zheng, Xiangyu; Li, Hongli; He, Yi; Yuan, Mingwei; Shen, Meili; Yang, Renyu; Jiang, Nianfeng; Yuan, Minglong; Yang, Cui. 2019. "Preparation and In Vitro Release of Total Alkaloids from Alstonia Scholaris Leaves Loaded mPEG-PLA Microspheres." Materials 12, no. 9: 1457.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.