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Materials 2019, 12(6), 868; https://doi.org/10.3390/ma12060868

Unsaturated Poly(Hydroxyalkanoates) for the Production of Nanoparticles and the Effect of Cross-Linking on Nanoparticle Features

1
Department of Drug Sciences, Section of Pharmaceutical Technology; University of Catania, Catania 95125, Italy
2
NANO-I, Research Center on Ocular Nanotechnology, University of Catania, Catania 95125, Italy
3
CNR, Institute for Polymers, Composites and Biomaterials, Catania 95126, Italy
4
Department of Chemical, Biological, Pharmaceutical and Environmental Science, University of Messina, Messina 98166, Italy
5
Department of Drug Sciences, Section of Chemistry; University of Catania, Catania 95125, Italy
*
Author to whom correspondence should be addressed.
Received: 7 January 2019 / Revised: 7 March 2019 / Accepted: 8 March 2019 / Published: 15 March 2019
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Abstract

A biodegradable poly(3-R-hydroxyalkanoate) synthesized by Pseudomonas mediterranea was investigated as a biomaterial to obtain colloidal drug delivery systems. Using a nanoprecipitation method, nanoparticles with a mean size of 155 nm and a negative surface charge were formed. They can be freeze-dried by adding hydroxypropyl-β-cyclodextrin as a cryoprotectant, and they have been shown to efficiently load both a hydrophilic (calcein) and a lipophilic (Nile red) model probe. Since this polymer contains terminal double bonds in the side chains, cross-linking conditions were tested. In particular, under the action of UV rays or irradiation with an incandescent yellow lamp, this polymer tended to cross-link. View Full-Text
Keywords: polymers; polyesters; calcein; Nile red; freeze-drying; cryoprotectants polymers; polyesters; calcein; Nile red; freeze-drying; cryoprotectants
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Pignatello, R.; Impallomeni, G.; Cupri, S.; Puzzo, G.; Curcio, C.; Rizzo, M.G.; Guglielmino, S.; Ballistreri, A. Unsaturated Poly(Hydroxyalkanoates) for the Production of Nanoparticles and the Effect of Cross-Linking on Nanoparticle Features. Materials 2019, 12, 868.

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