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Open AccessFeature PaperArticle

One-Pot Method for Preparation of Magnetic Multi-Core Nanocarriers for Drug Delivery

1
Department for Materials Synthesis, Jožef Stefan Institute, 1000 Ljubljana, Slovenia
2
Faculty of Pharmacy, University of Ljubljana, 1000 Ljubljana, Slovenia
3
Laboratory of Biophysics, Jožef Stefan Institute, 1000 Ljubljana, Slovenia
*
Author to whom correspondence should be addressed.
Materials 2019, 12(3), 540; https://doi.org/10.3390/ma12030540
Received: 19 January 2019 / Revised: 7 February 2019 / Accepted: 9 February 2019 / Published: 12 February 2019
The development of various magnetically-responsive nanostructures is of great importance in biomedicine. The controlled assembly of many small superparamagnetic nanocrystals into large multi-core clusters is needed for effective magnetic drug delivery. Here, we present a novel one-pot method for the preparation of multi-core clusters for drug delivery (i.e., magnetic nanocarriers). The method is based on hot homogenization of a hydrophobic phase containing a nonpolar surfactant into an aqueous phase, using ultrasonication. The solvent-free hydrophobic phase that contained tetradecan-1-ol, γ-Fe2O3 nanocrystals, orlistat, and surfactant was dispersed into a warm aqueous surfactant solution, with the formation of small droplets. Then, a pre-cooled aqueous phase was added for rapid cooling and the formation of solid magnetic nanocarriers. Two different nonpolar surfactants, polyethylene glycol dodecyl ether (B4) and our own N1,N1-dimethyl-N2-(tricosan-12-yl)ethane-1,2-diamine (SP11), were investigated for the preparation of MC-B4 and MC-SP11 magnetic nanocarriers, respectively. The nanocarriers formed were of spherical shape, with mean hydrodynamic sizes <160 nm, good colloidal stability, and high drug loading (7.65 wt.%). The MC-B4 nanocarriers showed prolonged drug release, while no drug release was seen for the MC-SP11 nanocarriers over the same time frame. Thus, the selection of a nonpolar surfactant for preparation of magnetic nanocarriers is crucial to enable drug release from nanocarrier. View Full-Text
Keywords: magnetic nanocrystals; magnetic drug delivery; nanocarriers; multi-core particles; magnetic nanoparticles; drug release magnetic nanocrystals; magnetic drug delivery; nanocarriers; multi-core particles; magnetic nanoparticles; drug release
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MDPI and ACS Style

Dragar, Č.; Potrč, T.; Nemec, S.; Roškar, R.; Pajk, S.; Kocbek, P.; Kralj, S. One-Pot Method for Preparation of Magnetic Multi-Core Nanocarriers for Drug Delivery. Materials 2019, 12, 540. https://doi.org/10.3390/ma12030540

AMA Style

Dragar Č, Potrč T, Nemec S, Roškar R, Pajk S, Kocbek P, Kralj S. One-Pot Method for Preparation of Magnetic Multi-Core Nanocarriers for Drug Delivery. Materials. 2019; 12(3):540. https://doi.org/10.3390/ma12030540

Chicago/Turabian Style

Dragar, Črt; Potrč, Tanja; Nemec, Sebastjan; Roškar, Robert; Pajk, Stane; Kocbek, Petra; Kralj, Slavko. 2019. "One-Pot Method for Preparation of Magnetic Multi-Core Nanocarriers for Drug Delivery" Materials 12, no. 3: 540. https://doi.org/10.3390/ma12030540

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Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

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