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Open AccessArticle

A Facile Synthesis of Core-Shell SiO2@Cu-LBMS Nano-Microspheres for Drug Sustained Release Systems

1
College of Chemistry and Chemical Engineering, Shaanxi Key Laboratory of Phytochemistry, Baoji University of Arts and Sciences, Baoji 721013, China
2
College of Physics and Optoelectronics Technology, Medical Micro-nano Materials Research Center, Baoji University of Arts and Sciences, Baoji 721016, China
*
Author to whom correspondence should be addressed.
Materials 2019, 12(23), 3978; https://doi.org/10.3390/ma12233978
Received: 16 October 2019 / Revised: 26 November 2019 / Accepted: 28 November 2019 / Published: 30 November 2019
A well-dispersed SiO2@Layered hydroxide cupric benzoate (SiO2@Cu-LBMS) with a hierarchical structure have been synthesized by a facile method. The layered hydroxide cupric benzoate with a structure of layered basic metal salt (Cu-LBMS) was directly deposited on the surface of silica spheres without any blinder. The morphology of the SiO2@Cu-LBMS nano-microsphere was observed by SEM, and the reaction conditions was also discussed. In addition, the XRD patterns and FTIR spectra provide consistent evidence to the formation of SiO2@Cu-LBMS nano-microspheres. The release behavior and drug loading capability of SiO2@Cu-LBMS microspheres were also investigated by using ibuprofen, aspirin and salicylic acid as model drugs. The results indicated that the drug loading capability of SiO2@Cu-LBMS nano-microspheres was much larger than layered hydroxide cupric benzoate, and the releasing time was significantly prolonged than layered hydroxide cupric benzoate and their physical mixture. View Full-Text
Keywords: layered hydroxide cupric benzoate; SiO2@Cu-LBMS; sustained release; drug loading capability layered hydroxide cupric benzoate; SiO2@Cu-LBMS; sustained release; drug loading capability
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MDPI and ACS Style

Wang, H.; Yang, H.; Zhao, L. A Facile Synthesis of Core-Shell SiO2@Cu-LBMS Nano-Microspheres for Drug Sustained Release Systems. Materials 2019, 12, 3978.

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