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Current State of Bone Adhesives—Necessities and Hurdles

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Department of Trauma Surgery, Orthopaedics and Plastic Surgery, University Medical Center Goettingen, Robert Koch Straße 40, 37075 Göttingen, Germany
2
Fraunhofer Institute for Manufacturing Technology and Advanced Materials (IFAM), Wiener Straße 12, 28359 Bremen, Germany
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Industrial and Environmental Biology, Hochschule Bremen—City University of Applied Sciences, Neustadtswall 30, 28199 Bremen, Germany
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Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Austrian Cluster for Tissue Regeneration, Donaueschingenstrasse 13, 1200 Vienna, Austria
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Faculty of Life Science, University of Vienna, Core Facility Cell Imaging and Ultrastructure Research, Althanstrasse 14, 1090 Vienna, Austria
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Department 2 Biology/Chemistry, University of Bremen, Leobener Straße 3, 28359 Bremen, Germany
7
Experimental Trauma Surgery, University Hospital Jena, 07747 Jena, Germany
*
Author to whom correspondence should be addressed.
These two authors contribute equally to the work.
Materials 2019, 12(23), 3975; https://doi.org/10.3390/ma12233975
Received: 30 October 2019 / Revised: 20 November 2019 / Accepted: 27 November 2019 / Published: 30 November 2019
(This article belongs to the Section Biomaterials)
The vision of gluing two bone fragments with biodegradable and biocompatible adhesives remains highly fascinating and attractive to orthopedic surgeons. Possibly shorter operation times, better stabilization, lower infection rates, and unnecessary removal make this approach very appealing. After 30 years of research in this field, the first adhesive systems are now appearing in scientific reports that may fulfill the comprehensive requirements of bioadhesives for bone. For a successful introduction into clinical application, special requirements of the musculoskeletal system, challenges in the production of a bone adhesive, as well as regulatory hurdles still need to be overcome. In this article, we will give an overview of existing synthetic polymers, biomimetic, and bio-based adhesive approaches, review the regulatory hurdles they face, and discuss perspectives of how bone adhesives could be efficiently introduced into clinical application, including legal regulations. View Full-Text
Keywords: bone; adhesive; glue; fracture; bioadhesive; osteosynthesis bone; adhesive; glue; fracture; bioadhesive; osteosynthesis
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Böker, K.O.; Richter, K.; Jäckle, K.; Taheri, S.; Grunwald, I.; Borcherding, K.; von Byern, J.; Hartwig, A.; Wildemann, B.; Schilling, A.F.; Lehmann, W. Current State of Bone Adhesives—Necessities and Hurdles. Materials 2019, 12, 3975.

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