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Open AccessArticle

Mechanical Properties, Biodegradation, and Biocompatibility of Ultrafine Grained Magnesium Alloy WE43

1
A.A. Baikov Institute of Metallurgy and Materials Science of the RAS, Moscow 119334, Russia
2
National University of Science and Technology “MISIS”, Moscow 119049, Russia
3
N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation, Moscow 115478, Russia
4
Belgorod National Research University, Belgorod 308015, Russia
5
Department of Materials Science and Engineering, Monash University, Melbourne 3800, Australia
6
Department of Mechanical Engineering, The University of Western Australia, Nedlands 6907, Australia
*
Author to whom correspondence should be addressed.
Materials 2019, 12(21), 3627; https://doi.org/10.3390/ma12213627
Received: 8 October 2019 / Revised: 25 October 2019 / Accepted: 1 November 2019 / Published: 4 November 2019
(This article belongs to the Special Issue Alloys for Biomedical Application)
In this work, the effect of an ultrafine-grained (UFG) structure obtained by multiaxial deformation (MAD) on the mechanical properties, fatigue strength, biodegradation, and biocompatibility in vivo of the magnesium alloy WE43 was studied. The grain refinement down to 0.93 ± 0.29 µm and the formation of Mg41Nd5 phase particles with an average size of 0.34 ± 0.21 µm were shown to raise the ultimate tensile strength to 300 MPa. Besides, MAD improved the ductility of the alloy, boosting the total elongation from 9% to 17.2%. An additional positive effect of MAD was an increase in the fatigue strength of the alloy from 90 to 165 MPa. The formation of the UFG structure also reduced the biodegradation rate of the alloy under both in vitro and in vivo conditions. The relative mass loss after six weeks of experiment was 83% and 19% in vitro and 46% and 7% in vivo for the initial and the deformed alloy, respectively. Accumulation of hydrogen and the formation of necrotic masses were observed after implantation of alloy specimens in both conditions. Despite these detrimental phenomena, the desired replacement of the implant and the surrounding cavity with new connective tissue was observed in the areas of implantation. View Full-Text
Keywords: biomedical materials; magnesium alloys; multiaxial deformation; ultrafine grain structure; mechanical properties; fatigue strength; biodegradation; biocompatibility biomedical materials; magnesium alloys; multiaxial deformation; ultrafine grain structure; mechanical properties; fatigue strength; biodegradation; biocompatibility
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Dobatkin, S.; Martynenko, N.; Anisimova, N.; Kiselevskiy, M.; Prosvirnin, D.; Terentiev, V.; Yurchenko, N.; Salishchev, G.; Estrin, Y. Mechanical Properties, Biodegradation, and Biocompatibility of Ultrafine Grained Magnesium Alloy WE43. Materials 2019, 12, 3627.

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