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Open AccessArticle

Novel Aminoacridine Sensors Based on Molecularly Imprinted Hybrid Polymeric Membranes for Static and Hydrodynamic Drug Quality Control Monitoring

1
Department of Chemistry, Faculty of Science, Ain Shams University, Abbasia 11566, Cairo, Egypt
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Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
3
Applied Organic Chemistry Department, National Research Center, Dokki 12622, Giza, Egypt
4
Chemistry Department, Faculty of Sciences, University of Sharjah, Sharjah 27272, UAE
*
Authors to whom correspondence should be addressed.
Materials 2019, 12(20), 3327; https://doi.org/10.3390/ma12203327
Received: 9 September 2019 / Revised: 3 October 2019 / Accepted: 10 October 2019 / Published: 12 October 2019
Novel biomimetic potentiometric ion-selective electrodes (ISEs) were fabricated and designed for the assessment of aminoacridine (ACR) based on newly synthesized imprinted polymer (MIP) membranes. Thermal polymerization of methacrylic acid (MAA) or acrylamide (AM) as function monomer, aminoacridine as a template and ethylene glycol dimethacrylate (EGDMA) as across-linker, were utilizedto give the molecular recognition part. The membranes of sensors I andII consist of MIP based MAA and AM, respectively, dispersed in a poly(vinyl chloride) membrane plasticized with dioctyl phthalate (DOP) in the ratio of 3.0 wt%, 32.2 wt% and 64.8 wt%, respectively. Sensors III and IV were similarly prepared with added 1.0 wt% tetraphenyl borate (TPB) as an anionic discriminator. Sensors I and II exhibited near-Nernstian potential response to ACR+ with slopes of 51.2 ± 1.3 and 50.5 ± 1.4 mV/decade in a 0.01 M phosphate buffer of pH 6.0. The linear response coversthe concentration range of 5.2 × 10−6 to 1.0 × 10−3 M with a detection limit of 0.05 and 0.17 μg/mL for sensors I and II, respectively. The performance characteristics of these sensors were evaluated under static and hydrodynamic mode of operations. They were used for quality control assessment of aminoacridine in some pharmaceutical preparations and biological samples. View Full-Text
Keywords: potentiometric sensors; aminoacridine; quality control; flow injection analysis (FIA) potentiometric sensors; aminoacridine; quality control; flow injection analysis (FIA)
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S. M. Hassan, S.; E. Amr, A. .-G.; Abd El-Naby, H.; El-Naggar, M.; H. Kamel, A.; M. Khalifa, N. Novel Aminoacridine Sensors Based on Molecularly Imprinted Hybrid Polymeric Membranes for Static and Hydrodynamic Drug Quality Control Monitoring. Materials 2019, 12, 3327.

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