Next Article in Journal
Effect of Surface Topography Parameters on Friction and Wear of Random Rough Surface
Next Article in Special Issue
Antibacterial Properties of a Novel Zirconium Phosphate-Glycinediphosphonate Loaded with Either Zinc or Silver
Previous Article in Journal
Impact of Gamma Radiation on Dynamic RDSON Characteristics in AlGaN/GaN Power HEMTs
Open AccessArticle

High Bactericidal Self-Assembled Nano-Monolayer of Silver Sulfadiazine on Hydroxylated Material Surfaces

1
Dipartimento di Chimica, Sezione di Chimica Generale, Università di Pavia, viale Taramelli 12, 27100 Pavia, Italy
2
Dipartimento di Scienze del Farmaco, Università di Pavia, viale Taramelli 10, 27100 Pavia, Italy
3
Dipartimento di Fisica, “A. Volta”, Università di Pavia, via Bassi 6, 27100 Pavia, Italy
4
Laboratorio di Patologia delle Infezioni Associate all’Impianto, IRCCS Istituto Ortopedico Rizzoli, via di Barbiano 1/10, 40136 Bologna, Italy
5
Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, via San Giacomo 14, 40126 Bologna, Italy
*
Authors to whom correspondence should be addressed.
Materials 2019, 12(17), 2761; https://doi.org/10.3390/ma12172761
Received: 14 July 2019 / Revised: 17 August 2019 / Accepted: 19 August 2019 / Published: 28 August 2019
(This article belongs to the Special Issue Anti-Infective Materials)
Anti-infective surfaces are a modern strategy to address the issue of infection related to the clinical use of materials for implants and medical devices. Nanocoatings, with their high surface/mass ratio, lend themselves to being mono-layered on the material surfaces to release antibacterial molecules and prevent bacterial adhesion. Here, a “layer-by-layer” (LbL) approach to achieve a self-assembled monolayer (SAM) with high microbicidal effect on hydroxylated surfaces is presented, exploiting the reaction between a monolayer of thiolic functions on glass/quartz surfaces and a newly synthesized derivative of the well-known antibacterial compound silver sulfadiazine. Using several different techniques, it is demonstrated that a nano-monolayer of silver sulfadiazine is formed on the surfaces. The surface-functionalized materials showed efficient bactericidal effect against both Gram-positive and Gram-negative bacteria. Interestingly, bactericidal self-assembled nano-monolayers of silver sulfadiazine could be achieved on a large variety of materials by simply pre-depositing glass-like SiO2 films on their surfaces. View Full-Text
Keywords: antimicrobial; nanocoatings; self-assembled monolayer; anti-infective materials; sulfadiazine antimicrobial; nanocoatings; self-assembled monolayer; anti-infective materials; sulfadiazine
Show Figures

Graphical abstract

MDPI and ACS Style

Taglietti, A.; Dacarro, G.; Barbieri, D.; Cucca, L.; Grisoli, P.; Patrini, M.; Arciola, C.R.; Pallavicini, P. High Bactericidal Self-Assembled Nano-Monolayer of Silver Sulfadiazine on Hydroxylated Material Surfaces. Materials 2019, 12, 2761.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop