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Oral Bone Tissue Engineering: Advanced Biomaterials for Cell Adhesion, Proliferation and Differentiation
Article

Engineering of Chitosan-Hydroxyapatite-Magnetite Hierarchical Scaffolds for Guided Bone Growth

1
Department of Engineering, University of Messina, Contrada Di Dio, I-98166 Messina, Italy
2
Laboratory of Advanced Biomaterials, Research School of Electrical, Energy and Materials Engineering, Australian National University, Canberra ACT 2601, Australia
3
Nanotechnology Research Laboratory, Research School of Electrical and Energy Engineering, Australian National University, Canberra ACT 2601, Australia
*
Author to whom correspondence should be addressed.
Materials 2019, 12(14), 2321; https://doi.org/10.3390/ma12142321
Received: 21 June 2019 / Revised: 11 July 2019 / Accepted: 16 July 2019 / Published: 20 July 2019
Bioabsorbable materials have received increasing attention as innovative systems for the development of osteoconductive biomaterials for bone tissue engineering. In this paper, chitosan-based composites were synthesized adding hydroxyapatite and/or magnetite in a chitosan matrix by in situ precipitation technique. Composites were characterized by optical and electron microscopy, thermogravimetric analyses (TGA), x-ray diffraction (XRD), and in vitro cell culture studies. Hydroxyapatite and magnetite were found to be homogeneously dispersed in the chitosan matrix and the composites showed superior biocompatibility and the ability to support cell attachment and proliferation; in particular, the chitosan/hydroxyapatite/magnetite composite (CS/HA/MGN) demonstrated superior bioactivity with respect to pure chitosan (CS) and to the chitosan/hydroxyapatite (CS/HA) scaffolds. View Full-Text
Keywords: chitosan/hydroxyapatite; osteoconduction; tissue engineering; magnetite chitosan/hydroxyapatite; osteoconduction; tissue engineering; magnetite
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MDPI and ACS Style

Pistone, A.; Iannazzo, D.; Celesti, C.; Piperopoulos, E.; Ashok, D.; Cembran, A.; Tricoli, A.; Nisbet, D. Engineering of Chitosan-Hydroxyapatite-Magnetite Hierarchical Scaffolds for Guided Bone Growth. Materials 2019, 12, 2321. https://doi.org/10.3390/ma12142321

AMA Style

Pistone A, Iannazzo D, Celesti C, Piperopoulos E, Ashok D, Cembran A, Tricoli A, Nisbet D. Engineering of Chitosan-Hydroxyapatite-Magnetite Hierarchical Scaffolds for Guided Bone Growth. Materials. 2019; 12(14):2321. https://doi.org/10.3390/ma12142321

Chicago/Turabian Style

Pistone, Alessandro, Daniela Iannazzo, Consuelo Celesti, Elpida Piperopoulos, Deepu Ashok, Arianna Cembran, Antonio Tricoli, and David Nisbet. 2019. "Engineering of Chitosan-Hydroxyapatite-Magnetite Hierarchical Scaffolds for Guided Bone Growth" Materials 12, no. 14: 2321. https://doi.org/10.3390/ma12142321

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