Next Article in Journal
Mode I Interlaminar Fracture of Glass/Epoxy Unidirectional Laminates. Part I: Experimental Studies
Previous Article in Journal
Study on the Product Characteristics of Pyrolysis Lignin with Calcium Salt Additives
Article Menu
Issue 10 (May-2) cover image

Export Article

Open AccessArticle

Nano-Carriers Based on pH-Sensitive Star-Shaped Copolymers for Drug-Controlled Release

1
School of Chemical Engineering & Light Industry, Guangdong University of Technology, Guangzhou 510006, China
2
School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China
*
Authors to whom correspondence should be addressed.
Materials 2019, 12(10), 1610; https://doi.org/10.3390/ma12101610
Received: 2 April 2019 / Revised: 4 May 2019 / Accepted: 13 May 2019 / Published: 16 May 2019
(This article belongs to the Special Issue Micro and Nanotechnologies in Biomedicines)
  |  
PDF [5718 KB, uploaded 16 May 2019]
  |  

Abstract

Polymeric nano-carriers are considered as promising tools in biomedical applications due to multiple attractive characteristics including their low toxicity, high loading capacity, controlled drug release capabilities, and highly tunable chemical properties. Here, a series of pH-sensitive star-shaped copolymers, Ad-P[(EMA-co-MAA)-b-PPEGMA]4, was prepared via electron transfer atom radical polymerization (ARGETE ATRP) and selective hydrolysis. These star-shaped copolymers can be self-assembled into micelles (Dh = 150–160 nm) and their critical micelle concentrations (CMC) were estimated to be 3.9–5.0 mg/L. The pH-sensitiveness of the micelles was evidenced by transmission electron microscopy (TEM) and dynamic light scattering (DLS). The maximal paclitaxel (PTX) loading efficiency (DLC) and entrapment efficiency (EE) were 18.9% and 36%, respectively. In vitro release studies revealed that about 19% of the PTX released at an acidic condition of pH 1.2 over 70 h, whereas more than 70% was released within the same time interval at pH 6.8. In vitro cytotoxicity suggested that the low cytotoxicity of the blank micelles, while the PTX-loaded micelles providing the cytotoxicity close to that of free PTX. These results indicated that this novel pH-sensitive nano-carriers have great potential applications for oral drug-controlled release. View Full-Text
Keywords: nano-carrier; pH-sensitive copolymer; drug release; adamantane nano-carrier; pH-sensitive copolymer; drug release; adamantane
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Jiang, W.; Guo, J.; Wen, W.; Jia, Y.-G.; Liu, S. Nano-Carriers Based on pH-Sensitive Star-Shaped Copolymers for Drug-Controlled Release. Materials 2019, 12, 1610.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top