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Open AccessArticle

Mesoporous Silicon Particles Favor the Induction of Long-Lived Humoral Responses in Mice to a Peptide-Based Vaccine

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Laboratorio de Biofarmacéuticos Recombinantes, Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, Av. Dr. Manuel Nava 6, San Luis Potosí 78210, Mexico
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Sección de Biotecnología, Centro de Investigación en Ciencias de la Salud y Biomedicina, Universidad Autónoma de San Luis Potosí, Av. Sierra Leona 550, Lomas 2ª. Sección, San Luis Potosí 78210, Mexico
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Consejo Nacional de Ciencia y Tecnología, CONACyT, Av. Insurgentes Sur 1582, Col. Crédito Constructor, Del. Benito Juarez, Ciudad de Mexico 03940, Mexico
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Laboratorio de Biopolímeros y Nanoestructuras, Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosi, Av. Dr. Manuel Nava 6, San Luis Potosí 78210, Mexico
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Author to whom correspondence should be addressed.
Materials 2018, 11(7), 1083; https://doi.org/10.3390/ma11071083
Received: 26 May 2018 / Revised: 12 June 2018 / Accepted: 13 June 2018 / Published: 26 June 2018
Vaccinology faces the challenge of developing improved immunization approaches that are able to induce long-term immunity with the desired Th profile according to the pathology. In this context, new vehicles for efficient antigen delivery that exert adjuvant effects play a critical role in addressing this goal. Herein, mesoporous silicon particles (PSiP) were assessed as carriers for a peptide-based vaccine targeting the receptor for advanced glycation end products (RAGE), which is a relevant receptor in Alzheimer´s disease and other diseases. A RAGE peptide was adsorbed onto PSiP (PSiP vaccine) and administered to BALB/c mice, leading to immune responses that were similar in magnitude to those induced by the soluble peptide. However, the response induced by PSiP lasted for a significantly longer period when compared with the behavior of the group immunized with the peptide alone. Therefore, PSiP are proposed as carriers to enhance immune memory, which is critical in vaccination. This study opens interesting perspectives related to the application of PSiP in vaccinology. View Full-Text
Keywords: humoral response; receptor for advanced glycation end products; adjuvant; peptide vaccine; vaccine delivery vehicle humoral response; receptor for advanced glycation end products; adjuvant; peptide vaccine; vaccine delivery vehicle
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MDPI and ACS Style

Navarro-Tovar, G.; Rocha-García, D.; Wong-Arce, A.; Palestino, G.; Rosales-Mendoza, S. Mesoporous Silicon Particles Favor the Induction of Long-Lived Humoral Responses in Mice to a Peptide-Based Vaccine. Materials 2018, 11, 1083.

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