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Open AccessArticle

Comparison of Six Different Silicones In Vitro for Application as Glaucoma Drainage Device

1
Small Animal Clinic, University of Veterinary Medicine Hannover, Foundation, D-30559 Hannover, Germany
2
Institute for Biomedical Engineering, Rostock University Medical Center, D-18119 Rostock, Germany
3
Laser Zentrum Hannover e.V., D-30419 Hannover, Germany
4
Leibniz Universität Hannover, D-30167 Hannover, Germany
*
Author to whom correspondence should be addressed.
Materials 2018, 11(3), 341; https://doi.org/10.3390/ma11030341
Received: 15 December 2017 / Revised: 30 January 2018 / Accepted: 24 February 2018 / Published: 27 February 2018
(This article belongs to the Section Biomaterials)
Silicones are widely used in medical applications. In ophthalmology, glaucoma drainage devices are utilized if conservative therapies are not applicable or have failed. Long-term success of these devices is limited by failure to control intraocular pressure due to fibrous encapsulation. Therefore, different medical approved silicones were tested in vitro for cell adhesion, cell proliferation and viability of human Sclera (hSF) and human Tenon fibroblasts (hTF). The silicones were analysed also depending on the sample preparation according to the manufacturer’s instructions. The surface quality was characterized with environmental scanning electron microscope (ESEM) and water contact angle measurements. All silicones showed homogeneous smooth and hydrophobic surfaces. Cell adhesion was significantly reduced on all silicones compared to the negative control. Proliferation index and cell viability were not influenced much. For development of a new glaucoma drainage device, the silicones Silbione LSR 4330 and Silbione LSR 4350, in this study, with low cell counts for hTF and low proliferation indices for hSF, and silicone Silastic MDX4-4210, with low cell counts for hSF and low proliferation indices for hTF, have shown the best results in vitro. Due to the high cell adhesion shown on Silicone LSR 40, 40,026, this material is unsuitable. View Full-Text
Keywords: silicone; glaucoma; fibrosis; Med-4234; SILUPRAN 2445A/B; Silastic MDX4-4210; LSR 40; 40,026; Silbione LSR 4330; Silbione LSR 4350 silicone; glaucoma; fibrosis; Med-4234; SILUPRAN 2445A/B; Silastic MDX4-4210; LSR 40; 40,026; Silbione LSR 4330; Silbione LSR 4350
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Windhövel, C.; Harder, L.; Bach, J.-P.; Teske, M.; Grabow, N.; Eickner, T.; Hinze, U.; Chichkov, B.; Nolte, I. Comparison of Six Different Silicones In Vitro for Application as Glaucoma Drainage Device. Materials 2018, 11, 341.

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