Thrombolysis Enhancing by Magnetic Manipulation of Fe3O4 Nanoparticles
Abstract
:1. Introduction
2. Materials and Methods
2.1. Preparation and Characterization of Magnetic Fe3O4 NPs
2.2. Experimental System
2.3. Thrombolysis Model in Microfluidic Channel
3. Results and Discussions
3.1. Observation of Thrombolysis Enhancing by Magnetic Fe3O4 NPs
3.2. Thrombolysis Test In Vitro
4. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
- Van Es, N.; Coppens, M.; Schulman, S.; Middeldorp, S.; Buller, H.R. Direct oral anticoagulants compared with vitamin K antagonists for acute venous thromboembolism: Evidence from phase 3 trials. Blood 2014, 124, 1968–1975. [Google Scholar] [CrossRef] [PubMed]
- Heit, J.A.; Spencer, F.A.; White, R.H. The epidemiology of venous thromboembolism. J. Thromb. Thrombolys. 2016, 41, 3–14. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Plicht, B.; Konorza, T.F.; Kahlert, P.; Al-Rashid, F.; Kaelsch, H.; Jánosi, R.A.; Buck, T.; Bachmann, H.S.; Siffert, W.; Heusch, G. Risk factors for thrombus formation on the Amplatzer Cardiac Plug after left atrial appendage occlusion. JACC Cardiovasc. Interv. 2013, 6, 606–613. [Google Scholar] [CrossRef] [PubMed]
- Empana, J.; Boulanger, C.M.; Tafflet, M.; Renard, J.M.; Leroyer, A.S.; Varenne, O.; Prugger, C.; Silvain, J.; Tedgui, A.; Cariou, A. Microparticles and sudden cardiac death due to coronary occlusion. The TIDE (Thrombus and Inflammation in sudden DEath) study. Eur. Heart J. Acute Cardiovasc. Care 2015, 4, 28–36. [Google Scholar] [CrossRef] [PubMed]
- Pan, S.; Tsai, T.; Chen, W.; Shen, C.; Tsuei, Y. An acute cerebral venous sinus thrombosis: Successful treatment by combining mechanical thrombolysis with continuous urokinase infusion. Clin. Neuroradiol. 2015, 25, 305–308. [Google Scholar] [CrossRef] [PubMed]
- Butcher, K.; Shuaib, A.; Saver, J.; Donnan, G.; Davis, S.M.; Norrving, B.; Wong, K.L.; Abd-Allah, F.; Bhatia, R.; Khan, A. Thrombolysis in the developing world: Is there a role for streptokinase? Int. J. Stroke 2013, 8, 560–565. [Google Scholar] [CrossRef] [PubMed]
- Goel, S.K.; Goel, I.; Agarwal, S. Effectiveness and comparison of reteplase versus streptokinase thrombolytic agents in the patients of acute myocardial infarction. Int. J. Med. Sci. Public Health 2017, 6, 568–573. [Google Scholar] [CrossRef]
- Chapman, S.N.; Mehndiratta, P.; Johansen, M.C.; McMurry, T.L.; Johnston, K.C.; Southerland, A.M. Current perspectives on the use of intravenous recombinant tissue plasminogen activator (tPA) for treatment of acute ischemic stroke. Vasc. Health Risk Manag. 2014, 10, 75–87. [Google Scholar] [PubMed]
- Chen, G.; Liu, Y.; Xie, Y.; Li, J.; Liu, H.; Sun, L.; Peng, Y.; Liu, F. High dose urokinase against massive pulmonary embolism in nephrotic syndrome. Blood Coagul. Fibrinolysis 2013, 24, 439–443. [Google Scholar] [CrossRef] [PubMed]
- De Martino, R.R.; Moran, S.L. The role of thrombolytics in acute and chronic occlusion of the hand. Hand Clin. 2015, 31, 13–21. [Google Scholar] [CrossRef] [PubMed]
- Imaizumi, T.; Inamura, S.; Kohama, I.; Yoshifuji, K.; Nomura, T.; Komatsu, K. Antithrombotic drug uses and deep intracerebral hemorrhages in stroke patients with deep cerebral microbleeds. J. Stroke Cerebrovasc. Dis. 2013, 22, 869–875. [Google Scholar] [CrossRef] [PubMed]
- Charidimou, A.; Nicoll, J.A.; McCarron, M.O. Thrombolysis-related intracerebral hemorrhage and cerebral amyloid angiopathy: Accumulating evidence. Front. Neurol. 2015, 6, 99. [Google Scholar] [CrossRef] [PubMed]
- Tsivgoulis, G.; Zand, R.; Katsanos, A.H.; Turc, G.; Nolte, C.H.; Jung, S.; Cordonnier, C.; Fiebach, J.B.; Scheitz, J.F.; Klinger-Gratz, P.P. Risk of symptomatic intracerebral hemorrhage after intravenous thrombolysis in patients with acute ischemic stroke and high cerebral microbleed burden: A meta-analysis. JAMA Neurol. 2016, 73, 675–683. [Google Scholar] [CrossRef] [PubMed]
- Suo, D.; Jin, Z.; Jiang, X.; Dayton, P.A.; Jing, Y. Microbubble mediated dual-frequency high intensity focused ultrasound thrombolysis: An In vitro study. Appl. Phys. Lett. 2017, 110, 023703. [Google Scholar] [CrossRef] [Green Version]
- Bader, K.B.; Gruber, M.J.; Holland, C.K. Shaken and stirred: Mechanisms of ultrasound-enhanced thrombolysis. Ultrasound Med. Biol. 2015, 41, 187–196. [Google Scholar] [CrossRef] [PubMed]
- De Saint Victor, M.; Carugo, D.; Coussios, C.; Stride, E.P. Ultrasound-enhanced thrombolysis: Mechanistic observations. J. Acoust. Soc. Am. 2015, 138, 1820. [Google Scholar] [CrossRef]
- Miller, D.L.; Smith, N.B.; Bailey, M.R.; Czarnota, G.J.; Hynynen, K.; Makin, I.R.S.; Bioeffects, C.O.T.A. Overview of therapeutic ultrasound applications and safety considerations. J. Ultrasound Med. 2012, 31, 623–634. [Google Scholar] [CrossRef] [PubMed]
- Chen, J.; Liu, C.; Hsu, H.; Wu, T.; Lu, Y.; Ma, Y. Magnetically controlled release of recombinant tissue plasminogen activator from chitosan nanocomposites for targeted thrombolysis. J. Mater. Chem. B 2016, 4, 2578–2590. [Google Scholar] [CrossRef]
- Watermann, A.; Brieger, J. Mesoporous Silica Nanoparticles as Drug Delivery Vehicles in Cancer. Nanomaterials 2017, 7, 189. [Google Scholar] [CrossRef] [PubMed]
- Hwang, A.A.; Lu, J.; Tamanoi, F.; Zink, J.I. Functional nanovalves on protein-coated nanoparticles for in vitro and in vivo controlled drug delivery. Small 2015, 11, 319–328. [Google Scholar] [CrossRef] [PubMed]
- Patra, S.; Roy, E.; Karfa, P.; Kumar, S.; Madhuri, R.; Sharma, P.K. Dual-responsive polymer coated superparamagnetic nanoparticle for targeted drug delivery and hyperthermia treatment. ACS Appl. Mater. Interfaces 2015, 7, 9235–9246. [Google Scholar] [CrossRef] [PubMed]
- Frank, L.A.; Contri, R.V.; Beck, R.C.; Pohlmann, A.R.; Guterres, S.S. Improving drug biological effects by encapsulation into polymeric nanocapsules. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 2015, 7, 623–639. [Google Scholar] [CrossRef] [PubMed]
- Chang, M.; Lin, Y.; Gabayno, J.L.; Li, Q.; Liu, X. Thrombolysis based on magnetically-controlled surface-functionalized Fe3O4 nanoparticle. Bioengineered 2017, 8, 29–35. [Google Scholar] [CrossRef] [PubMed]
- Korin, N.; Kanapathipillai, M.; Matthews, B.D.; Crescente, M.; Brill, A.; Mammoto, T.; Ghosh, K.; Jurek, S.; Bencherif, S.A.; Bhatta, D.; et al. Shear-Activated Nanotherapeutics for Drug Targeting to Obstructed Blood Vessels. Science 2012, 337, 738–742. [Google Scholar] [CrossRef] [PubMed]
- Lavik, E.; Ustin, J. Leveraging Shear Stress to Bust Clots with Nanoparticles. Science 2012, 337, 658–659. [Google Scholar] [CrossRef] [PubMed]
- Madaan, K.; Kumar, S.; Poonia, N.; Lather, V.; Pandita, D. Dendrimers in drug delivery and targeting: Drug-dendrimer interactions and toxicity issues. J. Pharm. Bioallied Sci. 2014, 6, 139–150. [Google Scholar] [PubMed]
- Dawidczyk, C.M.; Kim, C.; Park, J.H.; Russell, L.M.; Lee, K.H.; Pomper, M.G.; Searson, P.C. State-of-the-art in design rules for drug delivery platforms: Lessons learned from FDA-approved nanomedicines. J. Control. Release 2014, 187, 133–144. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Gabayno, J.L.F.; Liu, D.; Chang, M.; Lin, Y. Controlled manipulation of Fe3O4 nanoparticles in an oscillating magnetic field for fast ablation of microchannel occlusion. Nanoscale 2015, 7, 3947–3953. [Google Scholar] [CrossRef] [PubMed]
- Wu, K.C. CMR of microvascular obstruction and hemorrhage in myocardial infarction. J. Cardiovasc. Magn. R. 2012, 14, 68. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Kloner, R.A. The importance of no-reflow/microvascular obstruction in the STEMI patient. Eur. Heart J. 2017, 38, 3511–3513. [Google Scholar] [CrossRef] [PubMed]
- Serša, I.; Vidmar, J.; Grobelnik, B.; Mikac, U.; Tratar, G.; Blinc, A. Modelling the effect of laminar axially directed blood flow on the dissolution of non-occlusive blood clots. Phys. Med. Biol. 2007, 52, 2969–2985. [Google Scholar] [CrossRef] [PubMed]
- Rosenbluth, M.N.; Berk, H.L.; Doxas, I.; Horton, W. Effective diffusion in laminar convective flows. Phys. Fluids 1987, 30, 2636–2647. [Google Scholar] [CrossRef]
- Biswal, S.L.; Gast, A.P. Micromixing with linked chains of paramagnetic particles. Anal. Chem. 2004, 76, 6448–6455. [Google Scholar] [CrossRef] [PubMed]
- Chang, M.; Gabayno, J.L.F.; Ye, R.; Huang, K.; Chang, Y. Mixing efficiency enhancing in micromixer by controlled magnetic stirring of Fe3O4 nanomaterial. Microsyst. Technol. 2017, 23, 457–463. [Google Scholar] [CrossRef]
© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Share and Cite
Li, Q.; Liu, X.; Chang, M.; Lu, Z. Thrombolysis Enhancing by Magnetic Manipulation of Fe3O4 Nanoparticles. Materials 2018, 11, 2313. https://doi.org/10.3390/ma11112313
Li Q, Liu X, Chang M, Lu Z. Thrombolysis Enhancing by Magnetic Manipulation of Fe3O4 Nanoparticles. Materials. 2018; 11(11):2313. https://doi.org/10.3390/ma11112313
Chicago/Turabian StyleLi, Qian, Xiaojun Liu, Ming Chang, and Zhen Lu. 2018. "Thrombolysis Enhancing by Magnetic Manipulation of Fe3O4 Nanoparticles" Materials 11, no. 11: 2313. https://doi.org/10.3390/ma11112313