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Effects of Adding Polysaccharides and Citric Acid into Sodium Dihydrogen Phosphate Mixing Solution on the Material Properties of Gelatin-Hybridized Calcium-Phosphate Cement

1
Department of Applied Chemistry, School of Science and Technology, Meiji University, 1-1-1 Higashimita, Tama-ku, Kawasaki 214-8571, Japan
2
GUNZE LIMITED, 1 Zeze, Aono-cho, Ayabe 623-8511, Japan
3
Department of Medical Bioengineering, Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan
4
Kanagawa Academy of Science and Technology, 3-2-1 Sakado, Takatsu-ku, Kawasaki 213-0012, Japan
*
Author to whom correspondence should be addressed.
Materials 2017, 10(8), 941; https://doi.org/10.3390/ma10080941
Received: 28 June 2017 / Revised: 28 July 2017 / Accepted: 4 August 2017 / Published: 12 August 2017
We have succeeded in improving the material properties of a chelate-setting calcium-phosphate cement (CPC), which is composed of hydroxyapatite (HAp) the surface of which has been modified with inositol hexaphosphate (IP6) by adding α-tricalcium phosphate (α-TCP) powder. In order to create a novel chelate-setting CPC with sufficient bioresorbability, gelatin particles were added into the IP6-HAp/α-TCP cement system to modify the material properties. The effects of adding polysaccharides (chitosan, chondroitin sulfate, and sodium alginate) into the sodium dihydrogen phosphate mixing solution on the material properties of the gelatin-hybridized CPC were evaluated. The results of mechanical testing revealed that chondroitin sulfate would be the most suitable for fabricating the hybridized CPC with higher compressive strength. Moreover, further addition of an appropriate amount of citric acid could improve the anti-washout capability of the cement paste. In summary, a gelatin-hybridized IP6-HAp/α-TCP cement system prepared with a mixing solution containing chondroitin sulfate and citric acid is expected to be a beneficial CPC, with sufficient bioresorbability and material properties. View Full-Text
Keywords: gelatin particles; bioresorbability; α-tricalcium phosphate; calcium-phosphate cement; Inositol phosphate; anti-washout capability; mechanical property gelatin particles; bioresorbability; α-tricalcium phosphate; calcium-phosphate cement; Inositol phosphate; anti-washout capability; mechanical property
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Kiminami, K.; Konishi, T.; Mizumoto, M.; Nagata, K.; Honda, M.; Arimura, H.; Aizawa, M. Effects of Adding Polysaccharides and Citric Acid into Sodium Dihydrogen Phosphate Mixing Solution on the Material Properties of Gelatin-Hybridized Calcium-Phosphate Cement. Materials 2017, 10, 941.

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