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Materials 2017, 10(12), 1405;

Novel Development of Phosphate Treated Porous Hydroxyapatite

Department of Advanced Prosthodontics, Hiroshima University Graduate School of Biomedical and Health Sciences, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8553, Japan
Oral Implant Center, Tokushima University Hospital, 2-50-1, Kuramoto-machi, Tokushima 770-8503, Japan
Department of Dental Material Science and Technology, Hang Tuah University, Jalan Arief Rachman Hakim No. 150, Sukolilo, Surabaya 60111, Indonesia
Author to whom correspondence should be addressed.
Received: 3 October 2017 / Revised: 27 November 2017 / Accepted: 4 December 2017 / Published: 8 December 2017
(This article belongs to the Section Biomaterials)
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Phosphoric acid-etching treatment to the hydroxyapatite (HA) surface can modify the solubility calcium structure. The aim of the present study was to develop phosphate treated porous HA, and the characteristic structures and stimulation abilities of bone formation were evaluated to determine its suitability as a new type of bone graft material. Although the phosphoric acid-etching treatment did not alter the three-dimensional structure, a micrometer-scale rough surface topography was created on the porous HA surface. Compared to porous HA, the porosity of phosphate treated porous HA was slightly higher and the mechanical strength was lower. Two weeks after placement of the cylindrical porous or phosphate treated porous HA in a rabbit femur, newly formed bone was detected in both groups. At the central portion of the bone defect area, substantial bone formation was detected in the phosphate treated porous HA group, with a significantly higher bone formation ratio than detected in the porous HA group. These results indicate that phosphate treated porous HA has a superior surface topography and bone formation abilities in vivo owing to the capacity for both osteoconduction and stimulation abilities of bone formation conferred by phosphoric acid etching. View Full-Text
Keywords: porous hydroxyapatite; phosphoric acid-etching; phosphate treated hydroxyapatite porous hydroxyapatite; phosphoric acid-etching; phosphate treated hydroxyapatite

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Doi, K.; Abe, Y.; Kobatake, R.; Okazaki, Y.; Oki, Y.; Naito, Y.; Prananingrum, W.; Tsuga, K. Novel Development of Phosphate Treated Porous Hydroxyapatite. Materials 2017, 10, 1405.

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