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An Overview of Scaffold Design and Fabrication Technology for Engineered Knee Meniscus

1
Department of Industrial Design, Xi’an Jiaotong-Liverpool University, Suzhou 215123, China
2
National University of Singapore (Suzhou) Research Insititute, Suzhou 215123, China
3
Department of Mechanical Engineering, National University of Singapore, Singapore 117576, Singapore
*
Author to whom correspondence should be addressed.
Academic Editors: Chee Kai Chua, Wai Yee Yeong and Jia An
Materials 2017, 10(1), 29; https://doi.org/10.3390/ma10010029
Received: 29 October 2016 / Revised: 14 December 2016 / Accepted: 15 December 2016 / Published: 3 January 2017
(This article belongs to the Special Issue 3D Printing for Biomedical Engineering)
Current surgical treatments for meniscal tears suffer from subsequent degeneration of knee joints, limited donor organs and inconsistent post-treatment results. Three clinical scaffolds (Menaflex CMI, Actifit® scaffold and NUsurface® Meniscus Implant) are available on the market, but additional data are needed to properly evaluate their safety and effectiveness. Thus, many scaffold-based research activities have been done to develop new materials, structures and fabrication technologies to mimic native meniscus for cell attachment and subsequent tissue development, and restore functionalities of injured meniscus for long-term effects. This study begins with a synopsis of relevant structural features of meniscus and goes on to describe the critical considerations. Promising advances made in the field of meniscal scaffolding technology, in terms of biocompatible materials, fabrication methods, structure design and their impact on mechanical and biological properties are discussed in detail. Among all the scaffolding technologies, additive manufacturing (AM) is very promising because of its ability to precisely control fiber diameter, orientation, and pore network micro-architecture to mimic the native meniscus microenvironment. View Full-Text
Keywords: meniscal scaffold; additive manufacturing; scaffold design and fabrication meniscal scaffold; additive manufacturing; scaffold design and fabrication
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MDPI and ACS Style

Sun, J.; Vijayavenkataraman, S.; Liu, H. An Overview of Scaffold Design and Fabrication Technology for Engineered Knee Meniscus. Materials 2017, 10, 29.

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