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Volume 90
Issue 4
10.3390/scipharm90040068
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Article

Fabrication of Hydroxypropyl Methylcellulose Orodispersible Film Loaded Mirtazapine Using a Syringe Extrusion 3D Printer

by
Tanpong Chaiwarit
1,
Niphattha Aodsab
1,
Pimonnart Promyos
1,
Pattaraporn Panraksa
1,
Suruk Udomsom
2 and
Pensak Jantrawut
1,3,*
1
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand
2
Biomedical Engineering Institute, Chiang Mai University, Chiang Mai 50200, Thailand
3
Cluster of Research and Development of Pharmaceutical and Natural Products Innovation for Human or Animal, Chiang Mai University, Chiang Mai 50200, Thailand
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2022, 90(4), 68; https://doi.org/10.3390/scipharm90040068
Submission received: 6 October 2022 / Revised: 21 October 2022 / Accepted: 21 October 2022 / Published: 26 October 2022
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Abstract

Depression is a mental illness causing a continuous negative feeling and loss of interest and affects physical and mental health. Mirtazapine (MTZ) is an effective medicine for treating depression, but patients lack compliance. However, transforming a pharmaceutical dosage form to an orodispersible film (ODF) could resolve this issue. This study aims to fabricate ODF-loading mirtazapine, using a syringe extrusion 3D printer, and compare its properties with the solvent-casting method. The ODFs were prepared by dissolving the mirtazapine in a hydroxypropyl methylcellulose E15 solution, and then fabricated by a 3D printer or casting. The 3D printing was accurate and precise in fabricating the ODFs. The SEM micrographs showed that the mirtazapine-printed ODF (3D-MTZ) was porous, with crystals of mirtazapine on the film’s surface. The 3D-MTZ exhibited better mechanical properties than the mirtazapine-casted ODF (C-MTZ), due to the 3D-printing process. The disintegration time of the 3D-MTZ in a simulated salivary fluid, pH 6.8 at 37 °C, was 24.38 s, which is faster than the C-MTZ (46.75 s). The in vitro dissolution study, in 0.1 N HCl at 37 °C, found the 3D-MTZ quickly released the drug by more than 80% in 5 min. This study manifested that 3D-printing technology can potentially be applied for the fabrication of ODF-containing mirtazapine.
Keywords: orodispersible film; 3D-printing; hydroxypropyl methylcellulose; mirtazapine; depression orodispersible film; 3D-printing; hydroxypropyl methylcellulose; mirtazapine; depression

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MDPI and ACS Style

Chaiwarit, T.; Aodsab, N.; Promyos, P.; Panraksa, P.; Udomsom, S.; Jantrawut, P. Fabrication of Hydroxypropyl Methylcellulose Orodispersible Film Loaded Mirtazapine Using a Syringe Extrusion 3D Printer. Sci. Pharm. 2022, 90, 68. https://doi.org/10.3390/scipharm90040068

AMA Style

Chaiwarit T, Aodsab N, Promyos P, Panraksa P, Udomsom S, Jantrawut P. Fabrication of Hydroxypropyl Methylcellulose Orodispersible Film Loaded Mirtazapine Using a Syringe Extrusion 3D Printer. Scientia Pharmaceutica. 2022; 90(4):68. https://doi.org/10.3390/scipharm90040068

Chicago/Turabian Style

Chaiwarit, Tanpong, Niphattha Aodsab, Pimonnart Promyos, Pattaraporn Panraksa, Suruk Udomsom, and Pensak Jantrawut. 2022. "Fabrication of Hydroxypropyl Methylcellulose Orodispersible Film Loaded Mirtazapine Using a Syringe Extrusion 3D Printer" Scientia Pharmaceutica 90, no. 4: 68. https://doi.org/10.3390/scipharm90040068

APA Style

Chaiwarit, T., Aodsab, N., Promyos, P., Panraksa, P., Udomsom, S., & Jantrawut, P. (2022). Fabrication of Hydroxypropyl Methylcellulose Orodispersible Film Loaded Mirtazapine Using a Syringe Extrusion 3D Printer. Scientia Pharmaceutica, 90(4), 68. https://doi.org/10.3390/scipharm90040068

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