A Rare Case of Non-Hodgkin B-Cell Lymphoma Following Invasive Lobular Carcinoma of the Breast: A Case Report
Abstract
:1. Introduction
2. Case Presentation
3. Discussion
4. Conclusions
- A clinical follow-up (every 3–6 months for the first 2 years, then annually): comprehensive physical examination and blood tests, including complete blood count (CBC), lactate dehydrogenase (LDH) as a marker of lymphoma activity, tumor markers (CEA, CA 15-3), and liver and renal function tests.
- Imaging surveillance:
- –
- Breast ultrasound and chest and abdominal contrast-enhanced CT scan every 6 months for the first 2 years, then annually.
- –
- PET-CT scan after 6 months after the last one, then every 12 months (particularly if new symptoms or imaging changes arise).
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Sources | Age | Gender | Histology of BC | Stage | Main Findings | Surgical Treatments | Histology of NHL | Clinical Treatments |
---|---|---|---|---|---|---|---|---|
Weide, R., 1992 [15] | 71 | Female | Invasive ductal carcinoma | I | Hypoechogenicspleen lesions | Mastectomy, splenectomy | Low-grade NHL, centroblastic–centrocytic | NR |
Ueda, Y., 2022 [16] | 71 | Female | Invasive carcinoma ER—PR—HER2 + | NR | Splenic mass and multiple enlarged lymph nodes | Mastectomy, axillary lymph node dissection | Diffuse large B-cell lymphoma (DLBCL) | R-CHOP therapy, radiation therapy, and trastuzumab for NHL. The patient refused chemo and radiation therapy treatment post-mastectomy. |
Engin, H., 2022 [14] | 66 | Female | Invasive ductal carcinoma | IIA | Splenomegaly after 5 years of remission | Mastectomy, splenectomy | Marginal zone lymphoma | Chemo and radiotherapy for BC. The patient refused other treatments for NHL. |
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Bertulla, E.; Diaz, R.; Mascherini, M.; Casaccia, M.; Depaoli, F.; Cuniolo, L.; Cornacchia, C.; Margarino, C.; Murelli, F.; Franchelli, S.; et al. A Rare Case of Non-Hodgkin B-Cell Lymphoma Following Invasive Lobular Carcinoma of the Breast: A Case Report. Curr. Oncol. 2025, 32, 218. https://doi.org/10.3390/curroncol32040218
Bertulla E, Diaz R, Mascherini M, Casaccia M, Depaoli F, Cuniolo L, Cornacchia C, Margarino C, Murelli F, Franchelli S, et al. A Rare Case of Non-Hodgkin B-Cell Lymphoma Following Invasive Lobular Carcinoma of the Breast: A Case Report. Current Oncology. 2025; 32(4):218. https://doi.org/10.3390/curroncol32040218
Chicago/Turabian StyleBertulla, Elisa, Raquel Diaz, Matteo Mascherini, Marco Casaccia, Francesca Depaoli, Letizia Cuniolo, Chiara Cornacchia, Cecilia Margarino, Federica Murelli, Simonetta Franchelli, and et al. 2025. "A Rare Case of Non-Hodgkin B-Cell Lymphoma Following Invasive Lobular Carcinoma of the Breast: A Case Report" Current Oncology 32, no. 4: 218. https://doi.org/10.3390/curroncol32040218
APA StyleBertulla, E., Diaz, R., Mascherini, M., Casaccia, M., Depaoli, F., Cuniolo, L., Cornacchia, C., Margarino, C., Murelli, F., Franchelli, S., Pesce, M., Boccardo, C., Gipponi, M., De Cian, F., & Fregatti, P. (2025). A Rare Case of Non-Hodgkin B-Cell Lymphoma Following Invasive Lobular Carcinoma of the Breast: A Case Report. Current Oncology, 32(4), 218. https://doi.org/10.3390/curroncol32040218