Simultaneous Occurrence of Medullary Thyroid Carcinoma and Papillary Thyroid Carcinoma: A Case Series with Literature Review
Abstract
:1. Introduction
2. Materials and Methods
3. Case Presentations
3.1. Case 1
3.2. Case 2
3.3. Case 3
3.4. Case 4
3.5. Case 5
4. Results
5. Review of the Literature
6. Discussion
7. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Patient | PTC | MTC | |||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
N° | Gender | Age (Years) | Family History of Thyroid Disease | 1st Diagnosis | Other Thyroid Disease | Length of Follow-Up (Years) | Dimension (cm) | Lobe | Subtype | Stage | Molecular Mutation | Last Disease Status | Dimension (cm) | Lobe | Stage | RET Status | Pre-Operative Ct (pg/mL) | Last Ct (pg/mL) | Last Disease Status |
1 | M | 59 | Yes | MTC | CTL | 15 | 0.2 | Right | follicular | I | not investigated | NED | 1.3 | Left | III | negative | 894 | <2 | biochemically cured |
2 | F | 55 | Yes | MTC | MNG | 4 | 0.4 | Left | classic | I | not investigated | NED | 0.6 | Left | I | negative | 16.9 | <2 | biochemically cured |
3 | M | 56 | Yes | PTC | MNG | 5 | 1.1 | Left | classic | I | BRAF | NED | 0.2 | Right | I | negative | 6.3 | <2 | biochemically cured |
4 | F | 66 | No | MTC | MNG | 15 | 0.1 | Left | not specified | I | not investigated | NED | 2.8 | Right | III | negative | 478 | 1.8 | biochemically cured |
5 | M | 41 | Yes | MTC | MNG | 6 | 0.4 | Right | not specified | I | not investigated | NED | 4.7 | Left | II | negative | 2474 | 3295 | loco-regional disease |
Study | Number of Cases | Average Age | Gender | RET Status | RET Mutated Codon | Other Molecular Mutations | Prevalence of mPTC |
---|---|---|---|---|---|---|---|
Behrend et al., 2002 [9] | 1 | 61 | M | N/A | N/A | N/A | 100% |
Biscolla et al., 2004 [10] | 27 | 49.9 | 66% F | positive 5/27 (14%): all germinal | N/A | N/A | 77% |
Rossi et al., 2005 [5] | 1 sporadic MTC | 61 | F | exon 11 (somatic) | C634R | BRAF V600E | N/A |
2 hereditary MTC | 27 and 34 | 100% M | exon 15 (germinal) | both A891S | BRAF V600E | 0% | |
Younes et al., 2005 [11] | 1 | 55 | F | N/A | N/A | N/A | N/A |
Dionigi et al., 2007 [12] | 2 | 49.5 | 50% F | 1: negative 2: N/A | N/A | N/A | 100% |
Kim et al., 2010 [13] | 10 | 53 | 60% F | N/A | N/A | N/A | 90% |
Costanzo et al., 2010 [14] | 2 | N/A | 100% F | N/A | N/A | N/A | 100% |
Wong et al., 2012 [15] | 162 | 53 | 64% F | N/A | N/A | N/A | N/A |
Machens et al., 2012 [16] | 26 | 50 | 54% F | positive in 6/26 (23%): all germinal | 1 C634R 1 L709F 2 V804L 2 A891A | N/A | N/A (mean diameter 8 mm [3,4,5,6,7,8,9,10,11,12]) |
Verdi et al., 2012 [17] | 1 | 64 | M | negative | negative | N/A | 100% |
Adnan et al., 2013 [18] | 4 | 52.25 | 100% F | negative | negative | N/A | 100% |
Erhamamci et al., 2014 [19] | 4 | 53 | 75% F | N/A | N/A | N/A | 50% |
Fibbi et al., 2014 [20] | 1 | 47 | M | negative | negative | BRAF V600E | 100% |
Cheung et al., 2014 [21] | 1 | 59 | F | negative | negative | N/A | 100% |
Ciampi et al., 2016 [22] | 24 | 64 | 75% F | positive 10/24 (42%) germinal 2/10 (20%) | 1 germinal S918A, 1 germinal A804M; 8 somatic. M918T | 1/24: BRAF V600E 1/24: H-RAS 1/24: K-RAS | 78% |
Roshini et al., 2017 [23] | 11 | 27 | F | negative | negative | N/A | N/A |
Tang et al., 2017 [24] | 1 | 50 | F | N/A | N/A | N/A | 100% |
Gadong et al., 2019 [25] | 1 | 38 | F | exon 15 (germinal) | N/A | N/A | no |
Appetecchia et al., 2019 [3] | 183 | 56 | 58% F | evaluated 112/183: positive 24/112 (21%) negative 88/183 (48%) germinal 5/24 (21%) N/A 71/183 (39%) | see foot notes * | N/A | 81% |
Hellmann et al., 2020 [26] | 1 | 34 | M | negative | negative | negative | 100% |
Ziaolhagh et al., 2021 [27] | 1 | 62 | F | N/A | N/A | BRAF V600E | no |
Abdullah et al., 2022 [28] | 1 | 53 | M | N/A | N/A | N/A | 100% |
Our study | 5 | 55.4 | 60% M | negative | negative | 1/5: BRAF V600E | 80% |
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Fallahi, P.; Patrizio, A.; Stoppini, G.; Elia, G.; Ragusa, F.; Paparo, S.R.; Balestri, E.; Mazzi, V.; Botrini, C.; Varricchi, G.; et al. Simultaneous Occurrence of Medullary Thyroid Carcinoma and Papillary Thyroid Carcinoma: A Case Series with Literature Review. Curr. Oncol. 2023, 30, 10237-10248. https://doi.org/10.3390/curroncol30120745
Fallahi P, Patrizio A, Stoppini G, Elia G, Ragusa F, Paparo SR, Balestri E, Mazzi V, Botrini C, Varricchi G, et al. Simultaneous Occurrence of Medullary Thyroid Carcinoma and Papillary Thyroid Carcinoma: A Case Series with Literature Review. Current Oncology. 2023; 30(12):10237-10248. https://doi.org/10.3390/curroncol30120745
Chicago/Turabian StyleFallahi, Poupak, Armando Patrizio, Giulio Stoppini, Giusy Elia, Francesca Ragusa, Sabrina Rosaria Paparo, Eugenia Balestri, Valeria Mazzi, Chiara Botrini, Gilda Varricchi, and et al. 2023. "Simultaneous Occurrence of Medullary Thyroid Carcinoma and Papillary Thyroid Carcinoma: A Case Series with Literature Review" Current Oncology 30, no. 12: 10237-10248. https://doi.org/10.3390/curroncol30120745