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Article

An Oncology Urgent Care Clinic for the Management of Immune-Related Adverse Events: A Descriptive Analysis

1
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21287, USA
2
Division of General Internal Medicine, Johns Hopkins Bayview Medical Center, Baltimore, MD 21224, USA
3
Biostatistics, Epidemiology and Data Management Core, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
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Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD 21287, USA
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Department of Oncology, Beaumont Hospital Dublin, RCSI University of Health Sciences, D02 YN77 Dublin, Ireland
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Curr. Oncol. 2022, 29(6), 4342-4353; https://doi.org/10.3390/curroncol29060347
Received: 19 April 2022 / Revised: 26 May 2022 / Accepted: 14 June 2022 / Published: 17 June 2022
(This article belongs to the Section Medical Oncology)
Introduction: With the increasing use of immune checkpoint inhibitors (ICI) for cancer, there is a growing burden on the healthcare system to provide care for the toxicities associated with these agents. Herein, we aim to identify and describe the distribution of encounters seen in an urgent care setting for immune-related adverse events (irAEs) and the clinical outcomes from irAE management. Methods: Patient demographics, disease characteristics, and treatment data were collected retrospectively from encounters at an oncology Urgent Care Clinic (UCC) from a single tertiary center for upper aerodigestive malignancies from 1 July 2018 to 30 June 2019. Data were summarized using descriptive statistics with odds ratios for associations between patient features and hospitalization after UCC evaluation. Results: We identified 494 encounters from 289 individual patients over the study period. A history of ICI therapy was noted in 34% (n = 170/494) of encounters and 29 encounters (29/170, 17%) were confirmed and treated as irAEs. For those treated for irAEs, the majority (n = 19/29; 66%) were discharged home. Having an irAE was associated with an increased risk of hospitalization compared to non-irAEs (OR 5.66; 95% CI 2.15–14.89; p < 0.001). Conclusion: In this single institution experience, the majority of UCC encounters for confirmed irAEs were safely managed within the UCC. In ICI-treated patients, having an irAE was associated with an increased risk of hospitalization versus non-irAEs. View Full-Text
Keywords: immune-related adverse events; urgent care; care delivery; immune-checkpoint inhibitors; toxicity immune-related adverse events; urgent care; care delivery; immune-checkpoint inhibitors; toxicity
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MDPI and ACS Style

Liang, K.-l.; Tackett, S.; Myers, S.; Brahmer, J.R.; Browner, I.S.; Ettinger, D.S.; Forde, P.M.; Hales, R.K.; Hann, C.L.; Lam, V.K.; Marrone, K.A.; Patel, T.; Peterson, V.; Sagorsky, S.; Turner, M.; Voong, K.R.; Naidoo, J.; Feliciano, J.L. An Oncology Urgent Care Clinic for the Management of Immune-Related Adverse Events: A Descriptive Analysis. Curr. Oncol. 2022, 29, 4342-4353. https://doi.org/10.3390/curroncol29060347

AMA Style

Liang K-l, Tackett S, Myers S, Brahmer JR, Browner IS, Ettinger DS, Forde PM, Hales RK, Hann CL, Lam VK, Marrone KA, Patel T, Peterson V, Sagorsky S, Turner M, Voong KR, Naidoo J, Feliciano JL. An Oncology Urgent Care Clinic for the Management of Immune-Related Adverse Events: A Descriptive Analysis. Current Oncology. 2022; 29(6):4342-4353. https://doi.org/10.3390/curroncol29060347

Chicago/Turabian Style

Liang, Kai-li, Sean Tackett, Samantha Myers, Julie R. Brahmer, Ilene S. Browner, David S. Ettinger, Patrick M. Forde, Russell K. Hales, Christine L. Hann, Vincent K. Lam, Kristen A. Marrone, Tricia Patel, Valerie Peterson, Sarah Sagorsky, Michelle Turner, Khinh R. Voong, Jarushka Naidoo, and Josephine L. Feliciano. 2022. "An Oncology Urgent Care Clinic for the Management of Immune-Related Adverse Events: A Descriptive Analysis" Current Oncology 29, no. 6: 4342-4353. https://doi.org/10.3390/curroncol29060347

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