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Novel Therapeutic Method for Unresectable Pancreatic Cancer—The Impact of the Long-Term Research in Therapeutic Effect of High-Intensity Focused Ultrasound (HIFU) Therapy

1
Department of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1 Nishishinjuku Shinjuku-ku, Tokyo 160-0023, Japan
2
Department of Gastrointestinal and Pediatric Surgery, Tokyo Medical University, 6-7-1 Nishishinjuku Shinjuku-ku, Tokyo 160-0023, Japan
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2021, 28(6), 4845-4861; https://doi.org/10.3390/curroncol28060409
Received: 23 July 2021 / Revised: 18 September 2021 / Accepted: 17 November 2021 / Published: 20 November 2021
High-intensity focused ultrasound (HIFU) is a novel advanced therapy for unresectable pancreatic cancer (PC). HIFU therapy with chemotherapy is being promoted as a novel method to control local advancement by tumor ablation. We evaluated the therapeutic effects of HIFU therapy in locally advanced and metastatic PC. PC patients were treated with HIFU as an optional local therapy and systemic chemotherapy. The FEP-BY02 (Yuande Bio-Medical Engineering) HIFU device was used under ultrasound guidance. Of 176 PC patients, 89 cases were Stage III and 87 were Stage IV. The rate of complete tumor ablation was 90.3%, while that of symptom relief was 66.7%. The effectiveness on the primary lesions were as follows: complete response (CR): n = 0, partial response (PR): n = 21, stable disease (SD): n = 106, and progressive disease (PD): n = 49; the primary disease control rate was 72.2%. Eight patients underwent surgery. The median survival time (MST) after diagnosis for HIFU with chemotherapy compared to chemotherapy alone (100 patients in our hospital) was 648 vs. 288 days (p < 0.001). Compared with chemotherapy alone, the combination of HIFU therapy and chemotherapy demonstrated significant prolongation of prognosis. This study suggests that HIFU therapy has the potential to be a novel combination therapy for unresectable PC. View Full-Text
Keywords: high-intensity focused ultrasound (HIFU); pancreatic cancer; tumor ablation; combination therapy high-intensity focused ultrasound (HIFU); pancreatic cancer; tumor ablation; combination therapy
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MDPI and ACS Style

Sofuni, A.; Asai, Y.; Tsuchiya, T.; Ishii, K.; Tanaka, R.; Tonozuka, R.; Honjo, M.; Mukai, S.; Nagai, K.; Yamamoto, K.; Matsunami, Y.; Kurosawa, T.; Kojima, H.; Homma, T.; Minami, H.; Nakatsubo, R.; Hirakawa, N.; Miyazawa, H.; Nagakawa, Y.; Tsuchida, A.; Itoi, T. Novel Therapeutic Method for Unresectable Pancreatic Cancer—The Impact of the Long-Term Research in Therapeutic Effect of High-Intensity Focused Ultrasound (HIFU) Therapy. Curr. Oncol. 2021, 28, 4845-4861. https://doi.org/10.3390/curroncol28060409

AMA Style

Sofuni A, Asai Y, Tsuchiya T, Ishii K, Tanaka R, Tonozuka R, Honjo M, Mukai S, Nagai K, Yamamoto K, Matsunami Y, Kurosawa T, Kojima H, Homma T, Minami H, Nakatsubo R, Hirakawa N, Miyazawa H, Nagakawa Y, Tsuchida A, Itoi T. Novel Therapeutic Method for Unresectable Pancreatic Cancer—The Impact of the Long-Term Research in Therapeutic Effect of High-Intensity Focused Ultrasound (HIFU) Therapy. Current Oncology. 2021; 28(6):4845-4861. https://doi.org/10.3390/curroncol28060409

Chicago/Turabian Style

Sofuni, Atsushi, Yasutsugu Asai, Takayoshi Tsuchiya, Kentaro Ishii, Reina Tanaka, Ryosuke Tonozuka, Mitsuyoshi Honjo, Shuntaro Mukai, Kazumasa Nagai, Kenjiro Yamamoto, Yukitoshi Matsunami, Takashi Kurosawa, Hiroyuki Kojima, Toshihiro Homma, Hirohito Minami, Ryosuke Nakatsubo, Noriyuki Hirakawa, Hideaki Miyazawa, Yuichi Nagakawa, Akihiko Tsuchida, and Takao Itoi. 2021. "Novel Therapeutic Method for Unresectable Pancreatic Cancer—The Impact of the Long-Term Research in Therapeutic Effect of High-Intensity Focused Ultrasound (HIFU) Therapy" Current Oncology 28, no. 6: 4845-4861. https://doi.org/10.3390/curroncol28060409

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