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The Utility of Combined Target and Systematic Prostate Biopsies in the Diagnosis of Clinically Significant Prostate Cancer Using Prostate Imaging Reporting and Data System Version 2 Based on Biparametric Magnetic Resonance Imaging

1
Department of Urology, Gifu University Graduate School of Medicine, Gifu 5011194, Japan
2
Department of Urology, Ogaki Municipal Hospital, Ogaki 5038502, Japan
3
Department of Radiology, Gifu University Graduate School of Medicine, Gifu 5011194, Japan
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2021, 28(2), 1294-1301; https://doi.org/10.3390/curroncol28020123
Received: 14 February 2021 / Revised: 12 March 2021 / Accepted: 19 March 2021 / Published: 22 March 2021
(This article belongs to the Section Genitourinary Oncology)
This study aimed to determine the predictive value of the Prostate Imaging Reporting and Data System version 2 (PI-RADS v2) based on biparametric magnetic resonance imaging (bpMRI) with combined target biopsy (TBx) and systematic biopsy (SBx) in patients with suspicion of having clinically significant prostate cancer (csPCa). In this retrospective study, we reviewed the clinical and pathological records of 184 consecutive patients who underwent bpMRI before prostate biopsy. We focused on patients with PI-RADS v2 scores ≥ 3. MRI was performed using a 3-Tesla clinical scanner with a 32-channel phased-array receiver coil. PI-RADS v2 was used to describe bpMRI findings based on T2-weighted imaging and diffusion-weighted imaging scores. The primary endpoint was the diagnostic accuracy rate of PI-RADS v2 based on bpMRI for patients with prostate cancer (PCa) who underwent combined TBx and SBx. A total of 104 patients were enrolled in this study. Combined TBx and SBx was significantly superior to either method alone for PCa detection in patients with suspicious lesions according to PI-RADS v2. TBx and SBx detected concordant csPCa in only 24.1% of the patients. In addition, the rate of increase in the Gleason score was similar between SBx (41.5%) and TBx (34.1%). The diagnostic accuracy of bpMRI is comparable to that of standard multiparametric MRI for the detection of csPCa. Moreover, combined TBx and SBx may be optimal for the accurate determination of csPCa diagnosis, the International Society of Urological Pathology grade, and risk classification. View Full-Text
Keywords: prostate imaging reporting and data system; prostate biopsy; prostate cancer; positive predictive value prostate imaging reporting and data system; prostate biopsy; prostate cancer; positive predictive value
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MDPI and ACS Style

Kato, D.; Ozawa, K.; Takeuchi, S.; Kawase, M.; Kawase, K.; Nakai, C.; Takai, M.; Iinuma, K.; Nakane, K.; Kato, H.; Matsuo, M.; Suzui, N.; Miyazaki, T.; Koie, T. The Utility of Combined Target and Systematic Prostate Biopsies in the Diagnosis of Clinically Significant Prostate Cancer Using Prostate Imaging Reporting and Data System Version 2 Based on Biparametric Magnetic Resonance Imaging. Curr. Oncol. 2021, 28, 1294-1301. https://doi.org/10.3390/curroncol28020123

AMA Style

Kato D, Ozawa K, Takeuchi S, Kawase M, Kawase K, Nakai C, Takai M, Iinuma K, Nakane K, Kato H, Matsuo M, Suzui N, Miyazaki T, Koie T. The Utility of Combined Target and Systematic Prostate Biopsies in the Diagnosis of Clinically Significant Prostate Cancer Using Prostate Imaging Reporting and Data System Version 2 Based on Biparametric Magnetic Resonance Imaging. Current Oncology. 2021; 28(2):1294-1301. https://doi.org/10.3390/curroncol28020123

Chicago/Turabian Style

Kato, Daiki; Ozawa, Kaori; Takeuchi, Shinichi; Kawase, Makoto; Kawase, Kota; Nakai, Chie; Takai, Manabu; Iinuma, Koji; Nakane, Keita; Kato, Hiroki; Matsuo, Masayuki; Suzui, Natsuko; Miyazaki, Tatsuhiko; Koie, Takuya. 2021. "The Utility of Combined Target and Systematic Prostate Biopsies in the Diagnosis of Clinically Significant Prostate Cancer Using Prostate Imaging Reporting and Data System Version 2 Based on Biparametric Magnetic Resonance Imaging" Curr. Oncol. 28, no. 2: 1294-1301. https://doi.org/10.3390/curroncol28020123

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