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Current Oncology
Volume 27
Issue 5
10.3747/co.27.5757
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Article

Diagnostic Patterns of Non-Small-Cell Lung Cancer at Princess Margaret Cancer Centre

by
M. Nadjafi
†,
M.R. Sung
†,
G.D.C. Santos
,
L.W. Le
,
D.M. Hwang
,
M.S. Tsao
and
N.B. Leighl
*
Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to the present work.
Curr. Oncol. 2020, 27(5), 244-249; https://doi.org/10.3747/co.27.5757
Submission received: 5 July 2020 / Revised: 8 August 2020 / Accepted: 3 September 2020 / Published: 1 October 2020

Abstract

Background: Accurate classification of lung cancer subtypes has become critical in tailoring lung cancer treatment. Our study aimed to evaluate changes in diagnostic testing and pathologic subtyping of advanced non-small-cell lung cancer (NSCLC) over time at a major cancer centre. Methods: In a review of patients diagnosed with advanced NSCLC at Princess Margaret Cancer Centre between 2007–2009 and 2013–2015, diagnostic method, sample type and site, pathologic subtype, and use of immunohistochemistry (IHC) staining and molecular testing were abstracted. Results: The review identified 238 patients in 2007–2009 and 283 patients in 2013–2015. Over time, the proportion of patients diagnosed with adenocarcinoma increased to 73.1% from 60.9%, and diagnoses of NSCLC not otherwise specified (NOS) decreased to 6.4% from 18.9%, p < 0.0001. Use of diagnostic bronchoscopy decreased (26.9% vs. 18.4%), and mediastinal sampling procedures, including endobronchial ultrasonography, increased (9.2% vs. 20.5%, p = 0.0001). Use of IHC increased over time to 76.3% from 41.6% (p < 0.0001). Larger surgical or core biopsy samples and those for which IHC was performed were more likely to undergo biomarker testing (both p < 0.01). Conclusions: Customizing treatment based on pathologic subtype and molecular genotype has become key in treating patients with advanced lung cancer. Greater accuracy of pathology diagnosis is being achieved, including through the routine use of IHC.
Keywords: diagnostic testing; pathologic subtypes; immunohistochemistry; molecular testing; lung cancer diagnostic testing; pathologic subtypes; immunohistochemistry; molecular testing; lung cancer

Share and Cite

MDPI and ACS Style

Nadjafi, M.; Sung, M.R.; Santos, G.D.C.; Le, L.W.; Hwang, D.M.; Tsao, M.S.; Leighl, N.B. Diagnostic Patterns of Non-Small-Cell Lung Cancer at Princess Margaret Cancer Centre. Curr. Oncol. 2020, 27, 244-249. https://doi.org/10.3747/co.27.5757

AMA Style

Nadjafi M, Sung MR, Santos GDC, Le LW, Hwang DM, Tsao MS, Leighl NB. Diagnostic Patterns of Non-Small-Cell Lung Cancer at Princess Margaret Cancer Centre. Current Oncology. 2020; 27(5):244-249. https://doi.org/10.3747/co.27.5757

Chicago/Turabian Style

Nadjafi, M., M.R. Sung, G.D.C. Santos, L.W. Le, D.M. Hwang, M.S. Tsao, and N.B. Leighl. 2020. "Diagnostic Patterns of Non-Small-Cell Lung Cancer at Princess Margaret Cancer Centre" Current Oncology 27, no. 5: 244-249. https://doi.org/10.3747/co.27.5757

APA Style

Nadjafi, M., Sung, M. R., Santos, G. D. C., Le, L. W., Hwang, D. M., Tsao, M. S., & Leighl, N. B. (2020). Diagnostic Patterns of Non-Small-Cell Lung Cancer at Princess Margaret Cancer Centre. Current Oncology, 27(5), 244-249. https://doi.org/10.3747/co.27.5757

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