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Current Oncology
Volume 27
Issue 2
10.3747/co.27.5775
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Article

Epidemiology of Adult and Pediatric Burkitt Lymphoma in Canada: Sequelae of the HIV Epidemic

by
S.F. Roy
1,†,
F.M. Ghazawi
2,†,
M. Le
3,†,
F. Lagacé
3,4,
C.F. Roy
4,
E. Rahme
5,
E. Savin
3,
A. Zubarev
3,
D. Sasseville
3,
G. Popradi
6 and
I.V. Litvinov
3,*
1
Division of Pathology, University of Montreal, Montreal, QC, Canada
2
Division of Dermatology, University of Ottawa, Ottawa, ON, Canada
3
Division of Dermatology, McGill University, Montreal, QC, Canada
4
Faculty of Medicine, McGill University, Montreal, QC, Canada
5
Division of Clinical Epidemiology, McGill University, Montreal, QC, Canada
6
Division of Hematology, McGill University, Montreal, QC, Canada
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to the present work.
Curr. Oncol. 2020, 27(2), 83-89; https://doi.org/10.3747/co.27.5775
Submission received: 14 February 2020 / Revised: 13 March 2020 / Accepted: 12 April 2020 / Published: 1 May 2020

Abstract

Background: Although the pathogenesis and epidemiology of endemic Burkitt lymphoma (bl) have been extensively studied, the epidemiologic landscape of sporadic and immunodeficiency-associated bl in North America remains poorly understood. Methods: We used 3 distinct population-based cancer registries to retrospectively study bl incidence and mortality in Canada. Data for patient sex; age at the time of diagnosis; and reporting province, city, and forward sortation area (fsa, the first three characters of a postal code) were analyzed. Results: During 1992–2010, 1420 patients with bl in Canada were identified (incidence rate: 2.40 cases per million patient–years), of which 71.1% were male patients. Mean age at diagnosis was 55.5 ± 20.8 years. A bimodal incidence by age distribution was seen in both sexes, with pediatric- and adult-onset peaks. An analysis based on fsas identified select communities with statistically higher rates of adult bl. Several of those fsas were located within the 3 major metropolitan areas (Montreal, Vancouver, Toronto) and within self-identified lgbtq communities. The fsas with a higher socioeconomic status score were associated with lower rates of bl. Conclusions: Current results highlight the geographic and historic pattern of bl in Canada. The human immunodeficiency virus remains an important risk factor for adult bl.
Keywords: Burkitt lymphoma, pediatric; Burkitt lymphoma, adult; incidence in Canada; mortality in Canada; epidemiology in Canada; human immunodeficiency virus; HIV Burkitt lymphoma, pediatric; Burkitt lymphoma, adult; incidence in Canada; mortality in Canada; epidemiology in Canada; human immunodeficiency virus; HIV

Share and Cite

MDPI and ACS Style

Roy, S.F.; Ghazawi, F.M.; Le, M.; Lagacé, F.; Roy, C.F.; Rahme, E.; Savin, E.; Zubarev, A.; Sasseville, D.; Popradi, G.; et al. Epidemiology of Adult and Pediatric Burkitt Lymphoma in Canada: Sequelae of the HIV Epidemic. Curr. Oncol. 2020, 27, 83-89. https://doi.org/10.3747/co.27.5775

AMA Style

Roy SF, Ghazawi FM, Le M, Lagacé F, Roy CF, Rahme E, Savin E, Zubarev A, Sasseville D, Popradi G, et al. Epidemiology of Adult and Pediatric Burkitt Lymphoma in Canada: Sequelae of the HIV Epidemic. Current Oncology. 2020; 27(2):83-89. https://doi.org/10.3747/co.27.5775

Chicago/Turabian Style

Roy, S.F., F.M. Ghazawi, M. Le, F. Lagacé, C.F. Roy, E. Rahme, E. Savin, A. Zubarev, D. Sasseville, G. Popradi, and et al. 2020. "Epidemiology of Adult and Pediatric Burkitt Lymphoma in Canada: Sequelae of the HIV Epidemic" Current Oncology 27, no. 2: 83-89. https://doi.org/10.3747/co.27.5775

APA Style

Roy, S. F., Ghazawi, F. M., Le, M., Lagacé, F., Roy, C. F., Rahme, E., Savin, E., Zubarev, A., Sasseville, D., Popradi, G., & Litvinov, I. V. (2020). Epidemiology of Adult and Pediatric Burkitt Lymphoma in Canada: Sequelae of the HIV Epidemic. Current Oncology, 27(2), 83-89. https://doi.org/10.3747/co.27.5775

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