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Review

Nonsurgical Treatment of Recurrent Glioblastoma

Medical Oncology, Hospital Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
Curr. Oncol. 2015, 22(4), 273-281; https://doi.org/10.3747/co.22.2436
Submission received: 3 May 2015 / Revised: 5 June 2015 / Accepted: 7 July 2015 / Published: 1 August 2015

Abstract

Standard treatment for glioblastoma multiforme is surgery followed by radiotherapy and chemotherapy, generally with temozolomide. However, disease recurs in almost all patients. Diagnosis of progression is complex given the possibility of pseudoprogression. The Response Assessment in Neuro-Oncology criteria increase the sensitivity for detecting progression. Most patients will not be candidates for new surgery or re-irradiation, and anticancer drugs are the most common approach for second-line treatment, if the patient’s condition allows. Antiangiogenics, inhibitors of the epidermal growth factor receptor, nitrosoureas, and re-treatment with temozolomide have been studied in the second line, but a standard therapy has not yet been established. This review considers currently available medical treatment options for patients with glioblastoma recurrence.
Keywords: glioblastoma; chemotherapy; recurrent disease glioblastoma; chemotherapy; recurrent disease

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MDPI and ACS Style

Gallego, O. Nonsurgical Treatment of Recurrent Glioblastoma. Curr. Oncol. 2015, 22, 273-281. https://doi.org/10.3747/co.22.2436

AMA Style

Gallego O. Nonsurgical Treatment of Recurrent Glioblastoma. Current Oncology. 2015; 22(4):273-281. https://doi.org/10.3747/co.22.2436

Chicago/Turabian Style

Gallego, O. 2015. "Nonsurgical Treatment of Recurrent Glioblastoma" Current Oncology 22, no. 4: 273-281. https://doi.org/10.3747/co.22.2436

APA Style

Gallego, O. (2015). Nonsurgical Treatment of Recurrent Glioblastoma. Current Oncology, 22(4), 273-281. https://doi.org/10.3747/co.22.2436

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