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Current Oncology
Volume 20
Issue 5
10.3747/co.20.1338
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Article

Genitourinary Small-Cell Carcinoma: A Single-Institution Experience

by
N. Pervez
1,*,
F. El-Gehani
2,
K. Joseph
1,
A. Dechaphunkul
2,
M. Kamal
3,
D. Pertschy
4,
P. Venner
2,
S. Ghosh
2 and
S. North
2
1
Department of Radiation Oncology, University of Alberta and Cross Cancer Institute, Edmonton, AB, Canada
2
Department of Medical Oncology, University of Alberta and Cross Cancer Institute, Edmonton, AB, Canada
3
School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland
4
University of Alberta, Edmonton, AB, Canada
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2013, 20(5), 258-264; https://doi.org/10.3747/co.20.1338
Submission received: 2 July 2013 / Revised: 3 August 2013 / Accepted: 4 September 2013 / Published: 1 October 2013

Abstract

Background: Small-cell carcinomas (sccs) of the genitourinary (gu) tract are rare systemic diseases, and there is no standard treatment strategy for patients with this malignancy. The objectives of the present study were to report the management and outcome of patients with scc of the gu tract treated at a tertiary-care institution from 1982 to 2009. Methods: In a chart review of all patients diagnosed with scc of the gu tract between 1982 and 2009, data on demographics, clinical and pathologic characteristics, treatment, and patient outcomes were collected. Results: The 58 patients identified had scc in the following primary sites: urinary bladder (n = 35), prostate (n = 17), and upper urinary tract (n = 6). In 38 patients (66%), the scc was of pure histology; in the remainder, histology was mixed. Overall, 28 patients had limited-stage disease; 24 had extensive-stage disease; and staging was unknown in 6 patients. Median survival for the entire cohort was 7.5 months, with extensive-stage disease being identified as a poor prognostic factor (survival was 22.0 months for limited-stage patients and 4.1 months for extensive-stage patients, p < 0.001). Based on site, prostate patients fared worst, with a median survival of only 5.1 months. Compared with best supportive care, treatment was associated with better outcomes (median survival: 12.3 months vs. 2.3 months, p < 0.0001). Conclusions: Small-cell cancer of the gu tract is an aggressive cancer, with a poor prognosis overall. Although there is no standard of care, patients should be treated using a multimodality approach analogous to that used in the treatment of small-cell lung cancer.
Keywords: small-cell carcinoma; genitourinary tract; radiation; chemotherapy; surgery; retrospective review small-cell carcinoma; genitourinary tract; radiation; chemotherapy; surgery; retrospective review

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MDPI and ACS Style

Pervez, N.; El-Gehani, F.; Joseph, K.; Dechaphunkul, A.; Kamal, M.; Pertschy, D.; Venner, P.; Ghosh, S.; North, S. Genitourinary Small-Cell Carcinoma: A Single-Institution Experience. Curr. Oncol. 2013, 20, 258-264. https://doi.org/10.3747/co.20.1338

AMA Style

Pervez N, El-Gehani F, Joseph K, Dechaphunkul A, Kamal M, Pertschy D, Venner P, Ghosh S, North S. Genitourinary Small-Cell Carcinoma: A Single-Institution Experience. Current Oncology. 2013; 20(5):258-264. https://doi.org/10.3747/co.20.1338

Chicago/Turabian Style

Pervez, N., F. El-Gehani, K. Joseph, A. Dechaphunkul, M. Kamal, D. Pertschy, P. Venner, S. Ghosh, and S. North. 2013. "Genitourinary Small-Cell Carcinoma: A Single-Institution Experience" Current Oncology 20, no. 5: 258-264. https://doi.org/10.3747/co.20.1338

APA Style

Pervez, N., El-Gehani, F., Joseph, K., Dechaphunkul, A., Kamal, M., Pertschy, D., Venner, P., Ghosh, S., & North, S. (2013). Genitourinary Small-Cell Carcinoma: A Single-Institution Experience. Current Oncology, 20(5), 258-264. https://doi.org/10.3747/co.20.1338

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