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Current Oncology
Volume 20
Issue 4
10.3747/co.20.1353
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Article

Management of Penoscrotal Extramammary Paget Disease: Case Series and Review of the Literature

by
P. Moretto
1,*,
V.J. Nair
2,
S. El Hallani
3,
S. Malone
2,
E. Belanger
3,
C. Morash
4 and
C.M. Canil
1
1
Division of Medical Oncology, Department of Medicine, The Ottawa Hospital Cancer Centre, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada
2
Division of Radiation Oncology, Department of Radiology, The Ottawa Hospital Cancer Centre, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada
3
Division of Anatomical Pathology, Department of Pathology and Laboratory Medicine, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada
4
Division of Urology, The Ottawa Hospital Cancer Centre, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2013, 20(4), 311-320; https://doi.org/10.3747/co.20.1353
Submission received: 2 May 2013 / Revised: 3 June 2013 / Accepted: 4 July 2013 / Published: 1 August 2013

Abstract

Extramammary Paget disease (empd) is a rare, slow-growing neoplasm, considered to be an adenocarcinoma of the apocrine glands. In men, the penoscrotal region is the most commonly affected area. The disease can present as carcinoma in situ or as invasive disease that can subsequently metastasize to lymph nodes and distant sites. Because of the rarity of empd, the medical literature available to guide management of the disease is limited, particularly in patients with metastases. In addition, metastatic disease may pose a diagnostic challenge, because invasive cancer of the genitourinary or gastrointestinal tract can occur in association with empd. In the present case series, we describe our experience in treating penoscrotal empd with multimodality therapy, and we review the existing literature concerning its diagnosis and management.
Keywords: extramammary Paget disease; apocrine carcinoma; case series; treatment; pathology extramammary Paget disease; apocrine carcinoma; case series; treatment; pathology

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MDPI and ACS Style

Moretto, P.; Nair, V.J.; El Hallani, S.; Malone, S.; Belanger, E.; Morash, C.; Canil, C.M. Management of Penoscrotal Extramammary Paget Disease: Case Series and Review of the Literature. Curr. Oncol. 2013, 20, 311-320. https://doi.org/10.3747/co.20.1353

AMA Style

Moretto P, Nair VJ, El Hallani S, Malone S, Belanger E, Morash C, Canil CM. Management of Penoscrotal Extramammary Paget Disease: Case Series and Review of the Literature. Current Oncology. 2013; 20(4):311-320. https://doi.org/10.3747/co.20.1353

Chicago/Turabian Style

Moretto, P., V.J. Nair, S. El Hallani, S. Malone, E. Belanger, C. Morash, and C.M. Canil. 2013. "Management of Penoscrotal Extramammary Paget Disease: Case Series and Review of the Literature" Current Oncology 20, no. 4: 311-320. https://doi.org/10.3747/co.20.1353

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