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Cardiovascular Medicine
Volume 17
Issue 6
10.4414/cvm.2014.00252
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Cardiovascular Medicine is published by MDPI from Volume 28 Issue 1 (2025). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Editores Medicorum Helveticorum (EMH).
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Article

Influence of Diabetes Mellitus on Development of Heart Failure Following Anterior Myocardial Infarction

by
Costantina Manes
1,*,
Sally Greaves
2,
Marc A. Pfeffer
3,
John D. Rutherford
4,
Jean-Lucien Rouleau
5,
Charles Hennekens
6,7 and
Scott D. Solomon
3 On behalf of the Healing and Early Afterload Reducing Therapy (HEART) Study Investigators
1
University Heart Center Zurich, University Hospital Zurich, Zurich, Switzerland
2
Greenlane Cardiovascular Service, Auckland City Hospital, Auckland, New Zealand
3
Cardiovascular Division, Brigham and Women’s Hospital, Boston, MA, USA
4
UT Southwestern Medical Center, Dallas, TX, USA
5
Montreal Heart Institute, University of Montreal, Montreal, QC, Canada
6
Department of Biomedical Science, Center of Excellence, Florida Atlantic University, Boca Raton, FL, USA
7
Departments of Medicine & Epidemiology and Public Health, University of Miami Miller School of Medicine, Miami, FL, USA
*
Author to whom correspondence should be addressed.
Cardiovasc. Med. 2014, 17(6), 180; https://doi.org/10.4414/cvm.2014.00252
Submission received: 25 March 2014 / Revised: 25 April 2014 / Accepted: 25 May 2014 / Published: 25 June 2014
Versions Notes

Abstract

Background: Diabetic patients are at an increased risk of developing heart failure after myocardial infarction, particularly when left ventricular function is severely impaired. We aimed to investigate the influence of diabetes on the development of heart failure in a dynamically changing post-myocardial infarction population. Methods: In 272 patients enrolled in the Healing and Early Afterload Reducing Therapy (HEART) trial, left ventricular volumes, ejection fraction, and infarct segment length were assessed by echocardiography on day 1, day 14 and day 90. Echocardiographic measures, as well as clinical outcomes, were compared between diabetics and non-diabetics. Results: At presentation with myocardial infarction, diabetics (n = 56, 21%) demonstrated higher Killip class than non-diabetics (n = 216, 79%) despite similar infarct size. Changes in left ventricular size and function in the three months following infarction were similar in diabetics and non-diabetics. At one-year followup, diabetics demonstrated increased incidence of heart failure (29% versus 14%, p = 0.014) and total cardiovascular events (39% versus 19%, p = 0.002). Conclusions: The coexistence of diabetes enhances the risk for developing heart failure after myocardial infarction even in patients with mild left ventricular dysfunction or preserved ejection fraction. This risk is independent of infarct size, ejection fraction, or subsequent ventricular remodeling.
Keywords: myocardial infarction; diabetes mellitus; heart failure; echocardiography; remodelling myocardial infarction; diabetes mellitus; heart failure; echocardiography; remodelling

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MDPI and ACS Style

Manes, C.; Greaves, S.; Pfeffer, M.A.; Rutherford, J.D.; Rouleau, J.-L.; Hennekens, C.; Solomon, S.D., On behalf of the Healing and Early Afterload Reducing Therapy (HEART) Study Investigators. Influence of Diabetes Mellitus on Development of Heart Failure Following Anterior Myocardial Infarction. Cardiovasc. Med. 2014, 17, 180. https://doi.org/10.4414/cvm.2014.00252

AMA Style

Manes C, Greaves S, Pfeffer MA, Rutherford JD, Rouleau J-L, Hennekens C, Solomon SD On behalf of the Healing and Early Afterload Reducing Therapy (HEART) Study Investigators. Influence of Diabetes Mellitus on Development of Heart Failure Following Anterior Myocardial Infarction. Cardiovascular Medicine. 2014; 17(6):180. https://doi.org/10.4414/cvm.2014.00252

Chicago/Turabian Style

Manes, Costantina, Sally Greaves, Marc A. Pfeffer, John D. Rutherford, Jean-Lucien Rouleau, Charles Hennekens, and Scott D. Solomon On behalf of the Healing and Early Afterload Reducing Therapy (HEART) Study Investigators. 2014. "Influence of Diabetes Mellitus on Development of Heart Failure Following Anterior Myocardial Infarction" Cardiovascular Medicine 17, no. 6: 180. https://doi.org/10.4414/cvm.2014.00252

APA Style

Manes, C., Greaves, S., Pfeffer, M. A., Rutherford, J. D., Rouleau, J.-L., Hennekens, C., & Solomon, S. D., On behalf of the Healing and Early Afterload Reducing Therapy (HEART) Study Investigators. (2014). Influence of Diabetes Mellitus on Development of Heart Failure Following Anterior Myocardial Infarction. Cardiovascular Medicine, 17(6), 180. https://doi.org/10.4414/cvm.2014.00252

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