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Protective Effect of Anthocyanins from Lingonberry on Radiation-induced Damages

School of Forestry, Northeast Forestry University, 26 HeXing Road, XiangFang District, Harbin 150040, China
School of Food Science and Engineering, Harbin Institute of Technology, 73 HuangHe Road, NanGang District, Harbin 150090, China
College of Food Science and Technology, Henan University of Technology, Zhengzhou 450001, China
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2012, 9(12), 4732-4743;
Received: 19 October 2012 / Revised: 6 December 2012 / Accepted: 11 December 2012 / Published: 18 December 2012
There is a growing concern about the serious harm of radioactive materials, which are widely used in energy production, scientific research, medicine, industry and other areas. In recent years, owing to the great side effects of anti-radiation drugs, research on the radiation protectants has gradually expanded from the previous chemicals to the use of natural anti-radiation drugs and functional foods. Some reports have confirmed that anthocyanins are good antioxidants, which can effectively eliminate free radicals, but studies on the immunoregulatory and anti-radiation effects of anthocyanins from lingonberry (ALB) are less reported. In this experiment, mice were given orally once daily for 14 consecutive days before exposure to 6 Gy of gamma-radiation and were sacrificed on the 7th day post-irradiation. The results showed that the selected dose of extract did not lead to acute toxicity in mice; while groups given anthocyanins orally were significantly better than radiation control group according to blood analysis; pretreatment of anthocyanins significantly (p < 0.05) enhanced the thymus and spleen indices and spleen cell survival compared to the irradiation control group. Pretreatment with anthocyanins before irradiation significantly reduced the numbers of micronuclei (MN) in bone marrow polychromatic erythrocytes (PCEs). These findings indicate that anthocyanins have immunostimulatory potential against immunosuppression induced by the radiation. View Full-Text
Keywords: lingonberry; anthocyanins; radioprotection; immunomodulatory lingonberry; anthocyanins; radioprotection; immunomodulatory
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Fan, Z.-L.; Wang, Z.-Y.; Zuo, L.-L.; Tian, S.-Q. Protective Effect of Anthocyanins from Lingonberry on Radiation-induced Damages. Int. J. Environ. Res. Public Health 2012, 9, 4732-4743.

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