Next Article in Journal
Valuation of Mortality Risk Attributable to Climate Change: Investigating the Effect of Survey Administration Modes on a VSL
Next Article in Special Issue
Mouse Models for Efficacy Testing of Agents against Radiation Carcinogenesis — A Literature Review
Previous Article in Journal
Protective Effect of Anthocyanins from Lingonberry on Radiation-induced Damages
Previous Article in Special Issue
The Effects of Radiation and Dose-Fractionation on Cancer and Non-Tumor Disease Development
Article Menu

Export Article

Open AccessReview
Int. J. Environ. Res. Public Health 2012, 9(12), 4744-4759;

Second Malignant Neoplasms Following Radiotherapy

Department of Radiation Oncology, Henry Ford Hospital, Detroit MI 48202, USA
Received: 10 October 2012 / Revised: 6 December 2012 / Accepted: 6 December 2012 / Published: 18 December 2012
(This article belongs to the Special Issue Radiation and Cancer Risk)
Full-Text   |   PDF [1085 KB, uploaded 19 June 2014]   |  


More than half of all cancer patients receive radiotherapy as a part of their treatment. With the increasing number of long-term cancer survivors, there is a growing concern about the risk of radiation induced second malignant neoplasm [SMN]. This risk appears to be highest for survivors of childhood cancers. The exact mechanism and dose-response relationship for radiation induced malignancy is not well understood, however, there have been growing efforts to develop strategies for the prevention and mitigation of radiation induced cancers. This review article focuses on the incidence, etiology, and risk factors for SMN in various organs after radiotherapy. View Full-Text
Keywords: radiation; second malignancy; cancer therapy; side effects; radiotherapy; neoplasm radiation; second malignancy; cancer therapy; side effects; radiotherapy; neoplasm

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Kumar, S. Second Malignant Neoplasms Following Radiotherapy. Int. J. Environ. Res. Public Health 2012, 9, 4744-4759.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top