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Second Malignant Neoplasms Following Radiotherapy

Department of Radiation Oncology, Henry Ford Hospital, Detroit MI 48202, USA
Int. J. Environ. Res. Public Health 2012, 9(12), 4744-4759;
Received: 10 October 2012 / Revised: 6 December 2012 / Accepted: 6 December 2012 / Published: 18 December 2012
(This article belongs to the Special Issue Radiation and Cancer Risk)
More than half of all cancer patients receive radiotherapy as a part of their treatment. With the increasing number of long-term cancer survivors, there is a growing concern about the risk of radiation induced second malignant neoplasm [SMN]. This risk appears to be highest for survivors of childhood cancers. The exact mechanism and dose-response relationship for radiation induced malignancy is not well understood, however, there have been growing efforts to develop strategies for the prevention and mitigation of radiation induced cancers. This review article focuses on the incidence, etiology, and risk factors for SMN in various organs after radiotherapy. View Full-Text
Keywords: radiation; second malignancy; cancer therapy; side effects; radiotherapy; neoplasm radiation; second malignancy; cancer therapy; side effects; radiotherapy; neoplasm
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Kumar, S. Second Malignant Neoplasms Following Radiotherapy. Int. J. Environ. Res. Public Health 2012, 9, 4744-4759.

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