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Alcohol and Acetaldehyde in Public Health: From Marvel to Menace

by Rui Guo and Jun Ren *
Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, College of Health Sciences, WY 82071, USA
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2010, 7(4), 1285-1301;
Received: 11 January 2010 / Revised: 23 February 2010 / Accepted: 12 March 2010 / Published: 25 March 2010
(This article belongs to the Special Issue Alcohol and Public Health)
Alcohol abuse is a serious medical and social problem. Although light to moderate alcohol consumption is beneficial to cardiovascular health, heavy drinking often results in organ damage and social problems. In addition, genetic susceptibility to the effect of alcohol on cancer and coronary heart disease differs across the population. A number of mechanisms including direct the toxicity of ethanol, its metabolites [e.g., acetaldehyde and fatty acid ethyl esters (FAEEs)] and oxidative stress may mediate alcoholic complications. Acetaldehyde, the primary metabolic product of ethanol, is an important candidate toxin in developing alcoholic diseases. Meanwhile, free radicals produced during ethanol metabolism and FAEEs are also important triggers for alcoholic damages. View Full-Text
Keywords: alcohol; acetaldehyde; metabolism; human health alcohol; acetaldehyde; metabolism; human health
MDPI and ACS Style

Guo, R.; Ren, J. Alcohol and Acetaldehyde in Public Health: From Marvel to Menace. Int. J. Environ. Res. Public Health 2010, 7, 1285-1301.

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