Next Article in Journal
Epidemiological Study of Rickettsial Infections in Patients with Hypertransaminemia in Madrid (Spain)
Next Article in Special Issue
A History of Alcohol Dependence Increases the Incidence and Severity of Postoperative Cognitive Dysfunction in Cardiac Surgical Patients
Previous Article in Journal
Development, Methodology and Potential of the New Universal Visual Scoring System (UniViSS) for Caries Detection and Diagnosis
Previous Article in Special Issue
Alcohol Consumption and Development of Acute Respiratory Distress Syndrome: A Population-Based Study
Open AccessArticle

A Multicenter, Randomized, Open-Labeled, Parallel Group Trial of Sildenafil in Alcohol-Associated Erectile Dysfunction: The Impact on Psychosocial Outcomes

1
Mental Health Services, Ministry of Health, 2 Ben Tabai St., Jerusalem 93591, Israel
2
The Department of Substance Dependence Treatment, Ministry of Health, 20 King David St., Jerusalem 91010, Israel
3
Tirat Carmel Mental Health Center, Ministry of Health, 17 Ha'ela St., 'Tirat Carmel 30200, Israel Sha'ar Menashe Mental Health Center, Ministry of Health, Mobile Post Hefer 37806, Israel;
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2009, 6(9), 2510-2525; https://doi.org/10.3390/ijerph6092510
Received: 13 August 2009 / Accepted: 22 September 2009 / Published: 23 September 2009
(This article belongs to the Special Issue Alcohol and Public Health)
To examine the effect of sildenafil on erectile dysfunction (ED) and psychosocial outcomes in alcohol-dependent (AD) men, 108 men with these diagnoses were randomly assigned to either take sildenafil (50 mg) as add-on to standard treatment for AD, or the same treatment without sildenafil, for 12 weeks. Only 50 patients in sildenafil group and 51 in control group twice completed the International Index of Erectile Function (IIEF) and a battery of self-report questionnaires. IIEF scores and psychosocial functioning, self-esteem and support from friends improved only for sildenafil-treated patients (P < 0.001). The high effect sizes suggest that the observed benefits are unlikely to be a placebo effect, although their unspecific nature could not be ruled out. In men with ED associated with AD, sildenafil improves both ED and psychosocial outcomes. Further placebo-controlled clinical trial is warranted. View Full-Text
Keywords: alcohol dependence; erectile dysfunction; sildenafil; depression; functioning; self-esteem; social support alcohol dependence; erectile dysfunction; sildenafil; depression; functioning; self-esteem; social support
Show Figures

Graphical abstract

MDPI and ACS Style

Ponizovsky, A.M.; Averbuch, L.; Radomislensky, I.; Grinshpoon, A. A Multicenter, Randomized, Open-Labeled, Parallel Group Trial of Sildenafil in Alcohol-Associated Erectile Dysfunction: The Impact on Psychosocial Outcomes. Int. J. Environ. Res. Public Health 2009, 6, 2510-2525.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop