Interaction between Single Nucleotide Polymorphisms (SNP) of Tumor Necrosis Factor-Alpha (TNF-α) Gene and Plasma Arsenic and the Effect on Estimated Glomerular Filtration Rate (eGFR)
Abstract
:1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Factors | Mean (±SD)/n (%) | Median | IQR |
---|---|---|---|
Sex | |||
Male | 275 (55.78%) | - | - |
Female | 218 (44.33%) | - | - |
Age | 48.27 (±10.91) | 47 | 14 |
BMI | 24.43 (±3.46) | 24.15 | 4.21 |
Blood pressure | |||
Systolic BP | 115.24 (±17.51) | 112 | 22 |
Diastolic BP | 71.73 (±11.31) | 70 | 16 |
Smoking | |||
Non-smoking | 361 (73.23%) | - | - |
Smoking | 132 (26.77%) | - | - |
Chronic disease | |||
Diabetes | 28 (5.68%) | - | - |
Hyperlipidemia | 69 (14.00%) | - | - |
Hypertension | 56 (11.36%) | - | - |
Kidney stones | 36 (7.30%) | - | - |
Blood test | |||
BUN a (mg/dL) | 13.05 (±3.48) | 12.6 | 4.5 |
Creatinine (mg/dL) | 0.78 (±0.19) | 0.79 | 0.29 |
HbA1c a (%) | 5.66 (±0.55) | 5.6 | 0.4 |
Plasma-As a (µg/L) | 4.04 (±1.79) | 3.59 | 1.69 |
ln(Plasma-As) | 1.33 (±0.36) | 1.28 | 0.45 |
Kidney function | |||
CKDEPI eGFR | 101.36 (±14.25) | 102.74 | 18.06 |
SNP | Number (%) | H–W a | MAF a | CKDEPI eGFR b | Plasma As b |
---|---|---|---|---|---|
rs1799964 I | 493 | 0.1498 | 0.18 | ||
C/C | 20 (4.06%) | 101.28 (±13.59) | 3.89 (±2.09) | ||
C/T | 134 (27.18%) | 102.03 (±13.90) | 4.40 (±2.12) | ||
T/T | 339 (68.76%) | 101.11 (±14.45) | 3.91 (±1.61) | ||
rs1800629 I | 493 | 0.0023 | 0.11 | ||
A/A | 13 (2.64%) | 100.21 (±9.99) | 3.66 (±0.88) | ||
A/G | 85 (17.24%) | 99.98 (±14.72) | 3.97 (±1.59) | ||
G/G | 395 (80.12%) | 101.70 (±14.27) | 4.07 (±1.85) | ||
rs1800610 II | 492 | 0.8703 | 0.17 | ||
A/A | 13 (2.64%) | 104.10 (±16.59) | 4.31 (±2.12) | ||
A/G | 137 (27.79%) | 99.39 (±15.50) | 4.15 (±1.97) | ||
G/G | 342 (69.37%) | 102.03 (±13.59) | 3.99 (±1.71) | ||
rs3093662 II | 493 | 0.2132 | 0.03 | ||
G/G | 1 (0.20%) | 120.21 (-) | 2.34 (-) | ||
G/A | 23 (4.67%) | 100.76 (±16.61) | 4.07 (±1.09) | ||
A/A | 469 (95.13%) | 101.35 (±14.13) | 4.05 (±1.82) | ||
rs3093668 III | 493 | 0.0233 | 0.02 | ||
C/C | 1 (0.20%) | 0.7141 c | 120.21 (-) | 2.34 (-) | |
C/G | 15 (3.04%) | 97.09 (±16.31) | 3.99 (±1.07) | ||
G/G | 477 (96.75%) | 101.46 (±14.16) | 4.05 (±1.81) | ||
rs769177 IV | 493 | 0.4242 | 0.06 | ||
T/T | 1 (0.20%) | 110.84 (-) | 4.06 (-) | ||
T/C | 62 (12.58%) | 104.90 (±13.45) | 3.85 (±1.71) | ||
C/C | 430 (87.22%) | 100.83 (±14.31) | 4.07 (±1.81) | ||
rs769176 IV | 491 | 0.7311 | 0.02 | ||
T/T | 0 (0%) | - | - | ||
T/C | 15 (3.04%) | 98.33 (±13.83) | 3.95 (±1.12) | ||
C/C | 476 (96.55%) | 101.40 (±14.26) | 4.05 (±1.81) |
CKDEPI eGFR | β (SE) |
---|---|
ln(Plasma-As) | −7.92 (1.70) ** |
BMI | −0.41 (0.18) * |
Diabetes | |
Diabetes (vs. Non-Diabetes) | −5.00 (2.66) |
Hypertension | |
Hypertension (vs. Non-Hypertension) | −7.08 (1.56) ** |
Hyperlipidemia | |
Hyperlipidemia (vs. Non-Hyperlipidemia) | −1.69 (2.65) |
Kidney Stones | |
Kidney Stones (vs. Non-Kidney Stone)s | −1.32 (2.34) |
Smoking | |
Smoking (vs. Non-smoking) | −1.24 (1.44) |
Dependent Variable | CKDEPI eGFR | β (SE) |
---|---|---|
Model 1 | ln(Plasma-As) | −8.20 (1.71) ** |
rs1799964 | ||
CC (vs. TT) | −0.05 (3.09) | |
CT (vs. TT) | 1.79 (1.38) | |
Model 2 | ln(Plasma-As) | −7.98 (1.70) ** |
rs1800629 | ||
AA (vs. GG) | −3.38 (3.80) | |
AG (vs. GG) | −1.22 (1.61) | |
Model 3 | ln(Plasma-As) | −7.93 (1.70) ** |
rs1800610 | ||
AA (vs. GG) | 2.86 (3.81) | |
AG (vs. GG) | −2.42 (1.36) | |
Model 4 | ln(Plasma-As) | −7.84 (1.70) ** |
rs3093662 | ||
GG + GA (vs. AA) | 0.65 (2.84) | |
Model 5 | ln(Plasma-As) | −7.93 (1.70) ** |
rs3093668 | ||
CC + CG (vs. GG) | −2.33 (3.43) | |
Model 6 | ln(Plasma-As) | −7.74 (1.69) ** |
rs769177 | ||
TT + TC (vs.CC) | 4.02 (1.81) * | |
Model 7 | ln(Plasma-As) | −7.83 (1.70) ** |
rs769176 | ||
TC (vs. CC) | −2.71 (3.53) | |
Interaction models | ||
Model 8 | ln(Plasma-As) | −6.47 (1.87) * |
rs1800629 | ||
AA (vs. GG) | −12.08 (20.67) | |
AG (vs. GG) | 11.41 (6.23) | |
ln(Plasma-As) × rs1800629 | ||
AA (vs. GG) | 6.93 (15.99) | |
AG (vs. GG) | −9.59 (4.56) * | |
Model 9 | ln(Plasma-As) | −8.29 (1.71) ** |
rs769176 | ||
TC (vs. CC) | −41.32 (18.59) * | |
ln(Plasma-As) x rs769176 | ||
TC (vs. CC) | 28.83 (13.63) * |
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Fang, Y.-J.; Lin, K.-L.; Lee, J.-H.; Luo, K.-H.; Chen, T.-H.; Yang, C.-C.; Chuang, H.-Y. Interaction between Single Nucleotide Polymorphisms (SNP) of Tumor Necrosis Factor-Alpha (TNF-α) Gene and Plasma Arsenic and the Effect on Estimated Glomerular Filtration Rate (eGFR). Int. J. Environ. Res. Public Health 2022, 19, 4404. https://doi.org/10.3390/ijerph19074404
Fang Y-J, Lin K-L, Lee J-H, Luo K-H, Chen T-H, Yang C-C, Chuang H-Y. Interaction between Single Nucleotide Polymorphisms (SNP) of Tumor Necrosis Factor-Alpha (TNF-α) Gene and Plasma Arsenic and the Effect on Estimated Glomerular Filtration Rate (eGFR). International Journal of Environmental Research and Public Health. 2022; 19(7):4404. https://doi.org/10.3390/ijerph19074404
Chicago/Turabian StyleFang, Yi-Jen, Kuan-Lin Lin, Jyuhn-Hsiarn Lee, Kuei-Hau Luo, Tzu-Hua Chen, Chen-Cheng Yang, and Hung-Yi Chuang. 2022. "Interaction between Single Nucleotide Polymorphisms (SNP) of Tumor Necrosis Factor-Alpha (TNF-α) Gene and Plasma Arsenic and the Effect on Estimated Glomerular Filtration Rate (eGFR)" International Journal of Environmental Research and Public Health 19, no. 7: 4404. https://doi.org/10.3390/ijerph19074404