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Review

A Neurobiological Framework for the Therapeutic Potential of Music and Sound Interventions for Post-Traumatic Stress Symptoms in Critical Illness Survivors

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Faculty of Nursing, Edmonton Clinic Health Academy (ECHA), University of Alberta, 11405-87th Ave, Edmonton, AB T6G 1C9, Canada
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Department of Music, Faculty of Arts, University of Alberta, 3-98 Fine Arts Building, Edmonton, AB T6G 2C9, Canada
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Faculty of Medicine and Dentistry, University of Alberta, Walter C. MacKenzie Health Sciences Centre, Edmonton, AB T6G 2R7, Canada
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Canadian Centre for Ethnomusicology (CCE), University of Alberta, 11204-89 Ave NW, Edmonton, AB T6G 2J4, Canada
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School of Public Health, University of Alberta, ECHA 4-081, 11405-87 Ave NW, Edmonton, AB T6G 1C9, Canada
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Cardiovascular Health and Stroke Strategic Clinical Network, Alberta Health Services Corporate Office Seventh Street Plaza 14th Floor, North Tower 10030-107 Street NW, Edmonton, AB T5J 3E4, Canada
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Neurosciences Rehabilitation & Vision Strategic Clinical NetworkTM, Alberta Health Services Corporate Office Seventh Street Plaza 14th Floor, North Tower 10030-107 Street NW, Edmonton, AB T5J 3E4, Canada
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Author to whom correspondence should be addressed.
Academic Editors: Barbara Colombo and Osmano Oasi
Int. J. Environ. Res. Public Health 2022, 19(5), 3113; https://doi.org/10.3390/ijerph19053113
Received: 28 January 2022 / Revised: 25 February 2022 / Accepted: 3 March 2022 / Published: 6 March 2022
Overview: Post traumatic stress disorder (PTSD) has emerged as a severely debilitating psychiatric disorder associated with critical illness. Little progress has been made in the treatment of post-intensive care unit (ICU) PTSD. Aim: To synthesize neurobiological evidence on the pathophysiology of PTSD and the brain areas involved, and to highlight the potential of music to treat post-ICU PTSD. Methods: Critical narrative review to elucidate an evidence-based neurobiological framework to inform the study of music interventions for PTSD post-ICU. Literature searches were performed in PubMed and CINAHL. The Scale for the Assessment of Narrative Review Articles (SANRA) guided reporting. Results: A dysfunctional HPA axis feedback loop, an increased amygdalic response, hippocampal atrophy, and a hypoactive prefrontal cortex contribute to PTSD symptoms. Playing or listening to music can stimulate neurogenesis and neuroplasticity, enhance brain recovery, and normalize stress response. Additionally, evidence supports effectiveness of music to improve coping and emotional regulation, decrease dissociation symptoms, reduce depression and anxiety levels, and overall reduce severity of PTSD symptoms. Conclusions: Despite the lack of music interventions for ICU survivors, music has the potential to help people suffering from PTSD by decreasing amygdala activity, improving hippocampal and prefrontal brain function, and balancing the HPA-axis. View Full-Text
Keywords: music; post traumatic stress disorder; critical illness; neurobiology; autonomic nervous system; limbic system music; post traumatic stress disorder; critical illness; neurobiology; autonomic nervous system; limbic system
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MDPI and ACS Style

Pant, U.; Frishkopf, M.; Park, T.; Norris, C.M.; Papathanassoglou, E. A Neurobiological Framework for the Therapeutic Potential of Music and Sound Interventions for Post-Traumatic Stress Symptoms in Critical Illness Survivors. Int. J. Environ. Res. Public Health 2022, 19, 3113. https://doi.org/10.3390/ijerph19053113

AMA Style

Pant U, Frishkopf M, Park T, Norris CM, Papathanassoglou E. A Neurobiological Framework for the Therapeutic Potential of Music and Sound Interventions for Post-Traumatic Stress Symptoms in Critical Illness Survivors. International Journal of Environmental Research and Public Health. 2022; 19(5):3113. https://doi.org/10.3390/ijerph19053113

Chicago/Turabian Style

Pant, Usha, Michael Frishkopf, Tanya Park, Colleen M. Norris, and Elizabeth Papathanassoglou. 2022. "A Neurobiological Framework for the Therapeutic Potential of Music and Sound Interventions for Post-Traumatic Stress Symptoms in Critical Illness Survivors" International Journal of Environmental Research and Public Health 19, no. 5: 3113. https://doi.org/10.3390/ijerph19053113

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