The Prevalence of Ocular Extra-Intestinal Manifestations in Adults Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis
Abstract
1. Introduction
2. Methods
2.1. Literature Search
2.2. Study Selection and Data Extraction
2.3. Statistical Analysis
3. Results
3.1. Literature Search Results
3.2. The Characteristics of Included Studies
3.3. Association of O-EIMs with IBD
3.4. Stratification with World Regions
3.5. Chronological Analysis
3.6. Period Prevalence of O-EIMs
4. Discussion
Strengths and Limitations
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
References
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Study | Number | Country | Duration (years) | Definition of Uveitis | Uveitis | Episcleritis | Conjunctivitis | IBD | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
CD | UC | CD | UC | CD | UC | CD | UC | |||||
Bandyopadhyay 2015 [10] | 109 | India | 1.5 | uveitis | 11 | 0 | 2 | 14 | - | - | 51 | 58 |
Burisch 2019 [16] | 14,377 | Denmark | 15 | iridocyclitis | 103 | 154 | - | - | - | - | 3879 | 10,498 |
Card 2016 [17] | 45,312 | UK | 24 | uveitis | 636 | 811 | - | - | - | - | 18,204 | 27,108 |
Christodoulou 2002 [18] | 252 | Greece | 14 | iridocyclitis | 1 | 3 | 2 | 3 | - | - | 37 | 215 |
Elbadry 2022 [19] | 2001 | Egypt | 3 | uveitis | 1 | 4 | 0 | 6 | - | - | 207 | 897 |
Felekis 2009 [20] | 60 | Greece | N/M | uveitis | 4 | 1 | 0 | 2 | 1 | 0 | 23 | 37 |
Halling 2017 [21] | 44,409 | Denmark | 36 | iridocyclitis | 148 | 230 | 25 | 23 | - | - | 13,343 | 31,066 |
Hsu 2016 [22] | 3153 | Taiwan | 13 | iritis, uveitis | 2 | 4 | 1 | 2 | - | - | 547 | 2490 |
Isene 2014 [23] | 1145 | Multi-national * | 2 | iridocyclitis, uveitis | 5 | 5 | 1 | 0 | - | - | 364 | 781 |
Juliao-Banos 2020 [24] | 744 | Colombia | N/M | uveitis | 0 | 2 | 3 | 5 | - | - | 200 | 544 |
Karmiris 2016 [25] | 1860 | Greece | N/M | iridocyclitis, vitritis, choroiditis, retinitis | 28 | 10 | 16 | 0 | - | - | 1001 | 859 |
Lakatos 2003 [26] | 873 | Hungary | 25 | anterior uveitis | 4 | 6 | 4 | 9 | 1 | 4 | 254 | 619 |
Lee 2017 [27] | 61 | Korea | 1 | iritis | 2 | 1 | 1 | 0 | - | - | 36 | 25 |
Li 2016 [28] | 645 | China | 20 | uveitis | 2 | 3 | 5 | 2 | - | - | 128 | 517 |
Marin-Jimenez 2014 [29] | 518 | Spain | 2 | uveitis | 8 | 3 | - | - | - | - | 300 | 218 |
Park 2020 [30] | 1764 | Multi-national # | 16 | iritis, uveitis | 5 | 10 | 1 | 6 | - | - | 634 | 1130 |
Vadstrup 2020 [31] | 32,446 | Denmark | 13 | iritis, uveitis | 134 | 199 | - | - | - | - | 8769 | 20,722 |
Vavricka 2015 [4] | 1218 | Switzerland | 4 | uveitis | 39 | 11 | - | - | - | - | 735 | 483 |
Yang 2018 [32] | 43,281 | Korea | 1 | iridocyclitis | 113 | 368 | 55 | 139 | - | - | 13,925 | 29,356 |
Yuksel 2009 [33] | 352 | Turkey | 4.5 | uveitis | 4 | 2 | - | - | - | - | 118 | 234 |
Zippi 2014 [34] | 329 | Italy | 12 | uveitis | 16 | 10 | - | - | - | - | 119 | 210 |
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Li, J.-X.; Chiang, C.-C.; Chen, S.-N.; Lin, J.-M.; Tsai, Y.-Y. The Prevalence of Ocular Extra-Intestinal Manifestations in Adults Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis. Int. J. Environ. Res. Public Health 2022, 19, 15683. https://doi.org/10.3390/ijerph192315683
Li J-X, Chiang C-C, Chen S-N, Lin J-M, Tsai Y-Y. The Prevalence of Ocular Extra-Intestinal Manifestations in Adults Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis. International Journal of Environmental Research and Public Health. 2022; 19(23):15683. https://doi.org/10.3390/ijerph192315683
Chicago/Turabian StyleLi, Jing-Xing, Chun-Chi Chiang, San-Ni Chen, Jane-Ming Lin, and Yi-Yu Tsai. 2022. "The Prevalence of Ocular Extra-Intestinal Manifestations in Adults Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis" International Journal of Environmental Research and Public Health 19, no. 23: 15683. https://doi.org/10.3390/ijerph192315683
APA StyleLi, J.-X., Chiang, C.-C., Chen, S.-N., Lin, J.-M., & Tsai, Y.-Y. (2022). The Prevalence of Ocular Extra-Intestinal Manifestations in Adults Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis. International Journal of Environmental Research and Public Health, 19(23), 15683. https://doi.org/10.3390/ijerph192315683