The Association between the Respiratory System and Upper Limb Strength in Males with Duchenne Muscular Dystrophy: A New Field for Intervention?
, Eliza Wasilewska 2,*,†, Karolina Śledzińska 3, Joanna Jabłońska-Brudło 1, Sylwia Małgorzewicz 4, Andrzej Wasilewski 5 and Dominika Szalewska 1Round 1
Reviewer 1 Report
It is an interesting study, congratulation should be added
1: A setup bout the measurements
2: Some plots about the statistical result could improve the result communication
3: page 4, line 157,
"One point is given whether n task is performed 157 with compensations" was not clear to me.
Author Response
Reviewer 1
It is an interesting study, congratulation should be added
1: A setup bout the measurements
2: Some plots about the statistical result could improve the result communication
3: page 4, line 157,
"One point is given whether n task is performed 157 with compensations" was not clear to me.
Thank you for your kind and favourable review.
Results: We added more explanation in result section.
The project will be continue and the natural history of the cohort will be present in a more visual way – we thank Reviewer for inspiring suggestion.
We have changed the obvious grammatical error –line 157.
Reviewer 2 Report
Attached.
Comments for author File: 
Comments.pdf
Author Response
Reviewer 2
Thank you for your inspiring and valuable comments
In table 1, All the data are combined together. I would like to see data separated by ambulatory and non-ambulatory.
We added the data for ambulatory and non-ambulatory participants according to Reviewer suggestion.
As mentioned in the result section, the mean age at loss of ambulation is lower, I am not sure what authors are comparing (young vs old). Is it non-ambulated more severe because they are older? How age is a factor in FVC and FEV1? Age should also be used as a variable and analyzed to see its association with ambulation status.
DMD is progressive disease, however, this progression is not linear – depending on the individual disease dynamics increase in pulmonary and motor function in children till 7-10 years, after that time plateau is presented, and next parameters progressively decrease. So, we decided to present results in such a way (ambulatory/non-ambulatory) that the conclusions were more clear and obvious.
Since this is a cross-sectional study, if we have data on healthy individuals, that will be helpful to compare. Do the authors have any data or may historical data from healthy individuals, which can be used to compare data with? For example, based on table 3, how PUL score of ambulant patients compared with normal healthy individuals?
We added an explanation about values in healthy people as suggested by the reviewer.
