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Review

The Impact of Metal Nanoparticles on Female Reproductive System: Risks and Opportunities

Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, Italy
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Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2022, 19(21), 13748; https://doi.org/10.3390/ijerph192113748
Submission received: 30 September 2022 / Revised: 16 October 2022 / Accepted: 19 October 2022 / Published: 22 October 2022

Abstract

Humans have always been exposed to tiny particles via dust storms, volcanic ash, and other natural processes, and our bodily systems are well adapted to protect us from these potentially harmful external agents. However, technological advancement has dramatically increased the production of nanometer-sized particles or nanoparticles (NPs), and many epidemiological studies have confirmed a correlation between NP exposure and the onset of cardiovascular diseases and various cancers. Among the adverse effects on human health, in recent years, potential hazards of nanomaterials on female reproductive organs have received increasing concern. Several animal and human studies have shown that NPs can translocate to the ovary, uterus, and placenta, thus negatively impacting female reproductive potential and fetal health. However, NPs are increasingly being used for therapeutic purposes as tools capable of modifying the natural history of degenerative diseases. Here we briefly summarize the toxic effects of few but widely diffused NPs on female fertility and also the use of nanotechnologies as a new molecular approach for either specific pathological conditions, such as ovarian cancer and infertility, or the cryopreservation of gametes and embryos.
Keywords: nanoparticles; reprotoxicity; cryopreservation; ovarian cancer nanoparticles; reprotoxicity; cryopreservation; ovarian cancer

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MDPI and ACS Style

Aloisi, M.; Rossi, G.; Colafarina, S.; Guido, M.; Cecconi, S.; Poma, A.M.G. The Impact of Metal Nanoparticles on Female Reproductive System: Risks and Opportunities. Int. J. Environ. Res. Public Health 2022, 19, 13748. https://doi.org/10.3390/ijerph192113748

AMA Style

Aloisi M, Rossi G, Colafarina S, Guido M, Cecconi S, Poma AMG. The Impact of Metal Nanoparticles on Female Reproductive System: Risks and Opportunities. International Journal of Environmental Research and Public Health. 2022; 19(21):13748. https://doi.org/10.3390/ijerph192113748

Chicago/Turabian Style

Aloisi, Massimo, Gianna Rossi, Sabrina Colafarina, Maurizio Guido, Sandra Cecconi, and Anna M. G. Poma. 2022. "The Impact of Metal Nanoparticles on Female Reproductive System: Risks and Opportunities" International Journal of Environmental Research and Public Health 19, no. 21: 13748. https://doi.org/10.3390/ijerph192113748

APA Style

Aloisi, M., Rossi, G., Colafarina, S., Guido, M., Cecconi, S., & Poma, A. M. G. (2022). The Impact of Metal Nanoparticles on Female Reproductive System: Risks and Opportunities. International Journal of Environmental Research and Public Health, 19(21), 13748. https://doi.org/10.3390/ijerph192113748

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