Vitamin D Concentration and Motoric Cognitive Risk in Older Adults: Results from the Gait and Alzheimer Interactions Tracking (GAIT) Cohort
Abstract
:1. Introduction
2. Materials and Methods
2.1. Participants
2.2. Motoric Cognitive Risk Syndrome
2.3. Vitamin D Status
2.4. Covariates
2.5. Registrations
2.6. Statistics
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Age Group (y) | n | Men | n | Women |
---|---|---|---|---|
[65–69] | 96 | 98.82 | 62 | 87.25 |
[70–74] | 87 | 90.50 | 55 | 86.12 |
[75–79] | 47 | 90.70 | 24 | 82.01 |
≥80 | 9 | 72.63 | 9 | 75.87 |
Total Cohort (n = 244) | CHI (n = 178) | MCR (n = 66) | p-Value * | |
---|---|---|---|---|
Age (year), mean ± SD | 71.4 ± 3.7 | 71.2 ± 3.5 | 71.8 ± 4.2 | 0.574 |
Female sex, n (%) | 99 (40.6) | 74 (41.6) | 25 (37.9) | 0.602 |
Body mass index, n (%) | <0.001 | |||
<21 kg/m2 | 17 (7.0) | 14 (7.9) | 3 (4.6) | |
[21–30[ kg/m2 | 190 (77.9) | 149 (83.7) | 41 (62.1) | |
≥30 kg/m2 | 37 (15.2) | 15 (8.4) | 22 (33.3) | |
High education level †, n (%) | 145 (59.4) | 114 (64.0) | 31 (47.0) | 0.016 |
MMSE score (/30), mean ± SD | 28.0 ± 1.7 | 28.4 ± 1.4 | 27.1 ± 1.9 | <0.001 |
FAB score (/18), mean ± SD | 16.3 ± 1.6 | 16.7 ± 1.2 | 15.1 ± 2.1 | <0.001 |
Number of chronic diseases, mean ± SD | 2.0 ± 1.5 | 1.8 ± 1.4 | 2.6 ± 1.7 | <0.001 |
Use of psychoactive drugs ‡, n (%) | 42 (17.2) | 23 (12.9) | 19 (28.8) | 0.004 |
Hypovitaminosis D ||, n (%) | 59 (24.2) | 34 (19.1) | 25 (37.9) | 0.002 |
Unadjusted Model | Fully Adjusted Model | |||
---|---|---|---|---|
OR [95% CI] | p-Value | OR [95% CI] | p-Value | |
Hypovitaminosis D * | 2.58 [1.39; 4.81] | 0.003 | 2.61 [1.13; 6.06] | 0.025 |
Female sex | 0.67 [0.48; 1.53] | 0.602 | 1.06 [0.49; 2.32] | 0.881 |
Age | 1.04 [0.97; 1.12] | 0.283 | 0.201 | |
Body mass index | <0.001 | <0.001 | ||
<21 kg/m2 | 0.78 [0.21; 2.84] | 1.17 [0.25; 5.39] | ||
[21–30] kg/m2 | 1 | 1 | ||
≥30 kg/m2 | 5.33 [2.54; 11.19] | 6.65 [2.62; 16.87] | ||
High education level † | 0.50 [0.28; 0.88] | 0.017 | 0.77 [0.36; 1.63] | 0.490 |
MMSE score | 0.63 [0.52; 0.76] | <0.001 | 0.74 [0.59; 0.93] | 0.009 |
FAB score | 0.52 [0.42; 0.65] | <0.001 | 0.51 [0.39; 0.68] | <0.001 |
Number of chronic diseases | 1.39 [1.15; 1.67] | <0.001 | 1.29 [1.01; 1.65] | 0.043 |
Use psychoactive drugs ‡ | 2.72 [1.37; 5.43] | 0.004 | 2.55 [1.03; 6.36] | 0.044 |
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Le Floch, M.; Gautier, J.; Annweiler, C. Vitamin D Concentration and Motoric Cognitive Risk in Older Adults: Results from the Gait and Alzheimer Interactions Tracking (GAIT) Cohort. Int. J. Environ. Res. Public Health 2022, 19, 13086. https://doi.org/10.3390/ijerph192013086
Le Floch M, Gautier J, Annweiler C. Vitamin D Concentration and Motoric Cognitive Risk in Older Adults: Results from the Gait and Alzheimer Interactions Tracking (GAIT) Cohort. International Journal of Environmental Research and Public Health. 2022; 19(20):13086. https://doi.org/10.3390/ijerph192013086
Chicago/Turabian StyleLe Floch, Maxime, Jennifer Gautier, and Cédric Annweiler. 2022. "Vitamin D Concentration and Motoric Cognitive Risk in Older Adults: Results from the Gait and Alzheimer Interactions Tracking (GAIT) Cohort" International Journal of Environmental Research and Public Health 19, no. 20: 13086. https://doi.org/10.3390/ijerph192013086