Curative Potential of Substances with Bioactive Properties to Alleviate Cd Toxicity: A Review
Abstract
:1. Introduction
2. Cadmium Toxicity
3. Mitigation of Cd Toxicity via Food Supplementation
3.1. Vitamins
3.1.1. Vitamin C (Ascorbic Acid)
3.1.2. Vitamin E
3.2. Mineral Elements
3.2.1. Selenium
3.2.2. Zinc
3.2.3. Calcium
3.2.4. Silicon, Magnesium, Manganese
3.3. Bioactive Substances
3.3.1. Polyphenols, Phenols, and Phenolic Acids
Flavonoids
- Rutin hydrate
- Chrysin
- Diosmin
- Quercetin
- Hesperetin
- Anthocyanins
- Naringin
- Curcumin
- Carvacrol
Phenolic Acids
- Ferulic acid
- Vanillic acid
3.3.2. Hormones, Phytohormones, Metabolites
Salicylic Acid
Abscisic Acid
Melatonin
Fulvic Acid
3.4. Whole Plant Extracts
3.4.1. Senna alexandrina Extract
3.4.2. Portulaca oleracea (Purslane) Extract
3.4.3. Aronia melanocarpa L. Extract
3.4.4. Physalis peruviana L. Extract
3.4.5. Mimosa caesalpiniifolia Extract
3.4.6. Spirulina platensis Extract
3.4.7. Purple Carrot Extract
3.4.8. Grape Seed Extract and Grape Seed Proanthocyanidins
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Substances | Model | Dose of Substances | Dose of Cd | Detrimental Response to Cd Exposure and the Curative Effect of the Substance | Ref. |
---|---|---|---|---|---|
Vitamin C | Zea mays L. | 0.1–0.5 mM (4 weeks foliar application) | 50 mg kg−1 soil | Plant growth, photosynthesis, protein content, MDA content, H2O2 accumulation, CAT, SOD, GR activities, grains Cd uptake | Zhang et al., 2019 [51] |
Brassica napus L. | 250 and 500 mg kg−1 (single foliar application) | 10 μM (equal dose) | Ascorbate—glutathione cycle, ROS content | Jung et al., 2020 [53] | |
Triticum aestivum L. | 1 mM (seedlings preincubation) | 100 μM (equal dose) | AsA-GSH-NADPH cycle homeostasis, ROS generation | Wang et al., 2017 [52] | |
Schizosaccharomyces pombe L. | 10 mM (cell treatment for 30 min) | 10–400 μM (equal dose) | Ionome balance, CAT and SOD activity, MDA content, cell morphology | Navratilova et al., 2021 [54] | |
Rabbit | 150 mg kg−1 b.w. (oral administration for 28 days) | 1.5 mg kg−1 b.w. (oral administration for 28 days) | Cd accumulation, blood biochemical parameters | Mumtaz et al., 2019 [55]; Ali et al., 2020 [56] | |
Mouse | 50 and 100 mg kg−1 b.w. | 100 mg L−1 (in drinking water for 8 weeks) | Vascular disfunction, hypertension, oxidative damage | Donpunha et al., 2011 [57] | |
Vitamin E | Tilapia | 50 mg kg−1 diet for 12 weeks | 20 and 50 mg kg−1 diet | Serum creatine, ALT and AST activity, residual Cd content | Ayyat et al., 2017 [61] |
Ctenopharyngodon idellus | 20 IU kg−1 (single dose at day 4 after Cd injection) | 20 μM kg−1 single i.p. injection | Hepatocytes effect, MDA content, hepatocytes apoptosis and apoptosis-related gene, liver morphology, SOD, CAT, GPx activity | Duan et al., 2018 [62]; Huang et al., 2020 [63] | |
Mice | 100 mg kg−1 or 50 IU kg−1 | 5 mg kg−1 b.w. for 28 days, or 30 ppm for 7 weeks in drinking water | Liver weight and Cd content, ALT and AST content, hepatocellular necrosis, rupture in hepatocytes, inhibition of oxidative stress, antioxidant enzymes and expression of Nrf2 genes | Fang et al., 2021 [64]; Al-Attar 2011 [65] | |
Rat | 20 mg kg−1 b.w., 100 mg kg−1 b.w., 250 mg kg−1 b.w., or 40 and 400 mg kg−1 b.w., and 100 UI kg−1) | 20 mg kg−1 b.w. for 30 days, and 5 mg kg−1 b.w. for 28 days in the daily gavage; or i.p. 2 mg kg−1 b.w. for 8 or 28 days, or in drinking water 50 ppm for 20 weeks) | CAT, SOD, GR, GPx and GST, LPX, body weight effect, serum urea and creatinine, renal histological alterations, angiotensin converting enzyme, blood pressure, heart rate | Adi et al., 2016 [66], Fang et al., 2021 [67], Karabulut-Bulan et al., 2008 [68], Choi and Rhee 2003 [69] |
Substances | Model | Dose of Substances | Dose of Cd | Detrimental Response to Cd Exposure and the Curative Effect of the Substance | Ref. |
---|---|---|---|---|---|
Selenium | Chicken | 2 mg kg−1 or 0.5 mg kg−1 Se in the diet | 150 mg kg−1 for 90 or 120 days | Ionome alterations, amino acid content profile, MDA, DNA and protein crosslink, protein carbonyl content, CYP450, b5, GSH, AND, ERND, AH, cytochrome C reductase, CAT, SOD, GPX, caspase8, MAPK signaling pathway | Qu et al., 2020 [79], Cong et al., 2019 [81], Wang et al., 2020 [82] |
Avian leghorn male hepatoma cells | 1.25 or 2.5 μM | 2.5 μM (equal dose) for 24 h | Ca2+ homeostasis, calmodulin, alteration of the cadherin/calreticulin cycle, ER stress, autophagy leading to cell death | Zhang et al., 2020 [80] | |
porcine jejunal epithelial cells | 0.4 ppm in the cell culture medium for 24 h | 0.5–1 ppm in the media for 24 h | Cell viability, DNA damage, cell death | Lynch et al., 2017 [83] | |
Festuca pratensis L. | 0.1 mg L−1 dissolved in water | 30 mg L−1 for 7 days | Plant height, root length, MDA content, electrolyte leakage, antioxidant enzyme activities, photosynthetic efficiency, chlorophyll, and soluble protein content | Li et al., 2020 [84] | |
Raphanus sativus L. | 2–8 mg L−1 for 30 days | 5–10 mg L−1 for 30 days | Cd uptake, chlorophyll biosynthesis, micronutrients content, enzymatic antioxidant protective system | Auobi Amirabad et al., 2020 [85] | |
Triticum aestivum L. | 10–40 mg L−1 (foliar application for 6 months) | 0.3 mg kg−1 soil | Photosynthesis, plant biomass production, antioxidant enzymes activity | Wu et al., 2020 [86] | |
Zinc | SH-SY5Y catecholaminergic neuroblastoma cells | 50 μM (equal dose for 24 h) | 10 μM (equal dose for 24 h) | Attenuate the Cd-induced neurotoxicity | Branca et al., 2018 [92] |
MDBK epithelial cells | 10 and 50 μM (equal dose for 24 h) | 10 and 50 μM (equal dose for 24 h) | Cd uptake, Cd-mediated apoptotic cell death, mitochondrial damage and oxidative stress | Zhang et al., 2014 [93] | |
Saccharomyces cerevisiae | 40–640 μM (equal dose for 2 h) | 40–320 μM (equal dose for 2 h) | Genes expression alternation, ionome homeostasis and mitochondrial membrane potential, sulfur and GSH metabolism, ribosomal proteins, S-containing amino acids, S-rich proteins and antioxidant enzymes | Pan et al., 2017 [94] | |
Rats | 60 mg L−1 in drinking water during gestation and lactation | 50 mg L−1 in drinking water | Hippocampal volume, CA1, CA3 pyramidal cell layer and the dentate gyrus, SOD, metallothionein level, prenatal Zn metabolism | Mimouna et al., 2018 [95], Chemek et al., 2016 [98] | |
Sinopotamon henanense | 0.1–1 mg L−1 for 14 days | 0.05–0.5 mg L−1 for 14 days | Sperm count and motility, histological damage, morphological lesions, relative testis weight, SOD, CAT and GPx activity, MDA | Liu et al., 2020 [96], Babaknejad et al., 2018 [97] | |
Spodoptera exigua | 100–400 μg g−1 of food for 135 generations | 44 μg g−1 of food for 135 generations | DNA damage, ADP/ATP ratio, ATP and HSP70 concentrations, growth rate | Tarnawska et al., 2019 [99] | |
Triticum aestivum L. | 0.2% foliar spray, or 41.2 mg kg−1 soil | naturally contaminated water | Influx transporter gene TaNramp5, efflux transporters TaTM20 and TaHMA3, leaf TaHMA2, root TaLCT1 gene | Zhou et al., 2020 [101] | |
Spinaciae oleracea | 100 mg L−1 water for 2 weeks | 1 mg L−1 water for 2 weeks | Cu and Fe content | Sharifan et al., 2020 [102] | |
Petroselinum sativum | 100 mg L−1 water for 2 weeks | 1 mg L−1 water for 2 weeks | Cu and Fe content | Sharifan et al., 2020 [102] | |
Coriandrum sativum L. | 100 mg L−1 water for 2 weeks | 1 mg L−1 water for 2 weeks | Cu and Fe content | Sharifan et al., 2020 [102] | |
Matricaria chamomilla L. | 0.1–5 mM in hydroponic solution for 2 weeks | 120 and 180 μM in hydroponic solution for 2 weeks | ROS accumulation, MDA, antioxidant enzyme, reduced influx of Cd, biomass accumulation | Farzadfar et al., 2013 [105] | |
Arabidopsis thaliana L. | 3 mM (seedlings exposure for 5 days) | 50 μM (seedlings exposure for 5 days) | Oxidative stress, cell H2O2 content, lipid peroxidation, auxin content and distribution, root length | Li et al., 2016 [106] | |
Oryza sativa L. | 2.5 and 5 mg kg−1 soil (3 days), and 0.05–5 mM in BMS solution (till ripening stage) | 50 and 100 mg kg−1 soil (3 days), and 50 μM in BMS solution (till ripening stage) | Cd intake, oxidative stress, SOD, CAT and POD activity, photosynthesis, carotenoids, proline and protein content, grain yield and yield components, OsNRAMP1 and OsNRAMP5, OsHMA2, OsHMA3 transporter genes | Zhang et al., 2020 [107], Kanu et al., 2019 [108] | |
Calcium | Cicer arietinum L. | 100 mM (seeds exposure for 6 days) | 200 μM (seeds exposure for 6 days) | Oxidative stress, thioredoxin and thioredoxin reductase activities, SOD, CAT and APX | Sakouhi et al., 2021 [109] |
Hypogymnia physodes (L.) Nyl. | 100 and 1000 μM in water for 24 h | 10 and 100 μM in water for 24 h | ROS and MDA, thiol, glutathione, and ascorbic acid levels | Kováčik et al., 2020 [110] | |
Saccharomyces cerevisiae L. | 10 mM (in culture media for 60 min or 2–3 days) | 50–500 μM (in culture media for 60 min or 2–3 days) | Ca release from vacuole, Yvc1p transporter, Cch1p/Mid1p channel | Ruta et al., 2014 [111] | |
Bacillus sp. 98 | 5–30 mM (in culture media) | 0.2–4 mM (in culture media) | Intracellular NO production, NO synthase, NO dioxygenase, Fe uptake | Wu et al., 2021 [112] | |
Oncorhynchus mykiss | 30 and 60 mg g−1 food, or 20–60 mg kg−1 in diet | 50 μg L−1 in water for 7 days, or 3 μg L−1 in water, or 500 mg kg−1 diet for 28 days | Cd uptake, Cd transport, morphology | Baldisserotto et al., 2004 [113], Franklin et al., 2005 [114] | |
Oreochromis mossambicus | 0.2–0.8 mM freshwater concentration | 10 μg L−1 freshwater, or 10 μg per fish for 35 days | Cd transport, Cd accumulation in gill and gut, morphology | Pratap and Wendelaar Bonga 2007 [115] | |
Rat | 1–6% in milk or 0.4% solution or 100 mg kg−1 orally administered | 0.5 mg kg−1 b.w. for 10 days 1–50 mg kg−1 diet for 90 days or 44 mg L−1 in drinking water for 4 weeks | Cd content, ionome, bone formation, expression of osteogenic gene markers, fibroblast growth factor 23/Klotho-associated gene expression Cd-induced hepatotoxicity, MDA, H2O2, protein carbonyls, interleukin (IL) 1β, IL-6, IL17A, tumor necrosis factor-α, anti-inflammatory IL-10, IL-22 markers, GSH, GPx, CAT activities | Sarić et al., 2002 [116], Huang et al., 2019 [117], El-Boshy et al., 2020 [118] | |
Mice | 100 mg kg−1 diet | 10–1000 ppm in the diet for 28 days | Cd-induced nephrotoxicity, glomerular atrophy, renal proximal tubule injury, MDA, urine protein, KIM-1, apoptosi | Gu et al., 2020 [119] | |
Silicon | Boehmeria nivea (L.) Gaud | 1 mM in hydrophonic solution for 7 days | 5 mg L−1 in hydrophonic solution for 7 days | Cd translocation, SOD, CAT, POD, APX, ROS, MDA, H2O2, glutathione, ascorbate, vitamin E | Tang et al., 2015 [120] |
Oryza sativa L. | 5–20 mg L−1 foliar application | 0.84 mg kg−1 soil | Cd content, phytic acid | Hussain et al., 2020 [121] | |
Manganese | Phytolacca acinosa Roxb | 0.5–12 mM in hydrophonic solution for 17 days | 50–200 μM in hydrophonic solution for 17 days | Mn/Cd ratio, lipid peroxidation and plant water-loss, photosynthesis | Liu et al., 2013 [122] |
Mice | 20 mg kg−1 b.w. single i.p. injection | 7 mg kg−1 b.w. single s.c. injection | Cd content, GSH-Px activity, lipid peroxidation, GSH, CAT | Eybl and Kotyzová 2010 [123] | |
Magnesium | Rat blood plasma | 3 and 50 mg kg−1 b.w. i.p. or oral exposure 10 min or 1 h prior to Cd exposure | 30 mg kg−1 b.w. single dose administered by orogastric tube or 1.5 mg kg−1 b.w. i.p. injection of single dose | SOD activity, superoxide anion, total oxidative status, MDA and oxidation protein content | Buha et al., 2012 [125] |
Rat | 0.5 or 1.5 mg kg−1 b.w. i.p. injection for 21 days | 1 mg kg−1 b.w. i.p. injection for 21 days | Cd-induced nephrotoxicity, MDA, serum sodium, potassium, and urea levels, creatinine, and protein levels | Babaknejad et al., 2016 [126] | |
Isolated perfused rat liver model system | 1.2 mM for 90 min | 15 μM for 90 min | Glutathione level, enhanced MDA content and aminotransferase activity | Ghaffarian-Bahraman et al., 2014 [127] |
Substances | Model | Dose of Substances | Dose of Cd | Detrimental Response to Cd Exposure and the Curative Effect of the Substance | Ref. |
---|---|---|---|---|---|
Rutin | Rat | 25–100 mg kg−1 b.w. (oral administration for 14 or 30 days) | 5 mg kg−1 b.w. (oral administration for 14 or 30 days) | Neurotoxicity and cognitive disturbance, ERK1/2 and JNK apoptotic pathways, PTEN derived regulation of mTOR survival pathway, ectonucleotidases, adenosine deaminase and MAO activities | Oboh et al., 2019 [130], Abdel-Aleem and Khaleel 2018 [131] |
Chrysin | Mice | 2.5 and 5 mg kg−1 b.w. in drinking water for 30 days | 2 mg kg−1 b.w. in drinking water for 30 days | Hepatic stress, liver enzymes enhancement, morphological changes | Beyrami et al., 2020 [132] |
Diosmin | Rat | 100 mg kg−1 b.w. in drinking water for 30 days | 200 ppm in drinking water for 30 days | Hepatotoxicity, liver enzyme, antioxidant parameters, histopathological parameters | Ağır and Eraslan 2019 [133] |
Quercetin | Mice | 5–100 mg kg−1 b.w. by i.p. injection for 3 days | 0.4 mg kg−1 b.w. by i.p. injection for 3 days | Autophagosome formation, LC3-II/β-actin ratio, ROS, MDA content, antioxidant capacity | Yuan et al., 2016 [134] |
Primary rat proximal tubular cells | 1 μg mL−1 for 12 h | 2.5 μM for 12 h | Autophagy marker proteins, TFEB-dependent recovery of lysosomal function, v-ATPases | Zhao et al., 2021 [136] | |
Rat | 10 and 50 mg kg−1 b.w. by oral gavage for 12 weeks 50 mg kg−1 b.w. i.p. injection for 4 weeks | 4.89 mg kg−1 b.w. in drinking water for 12 weeks 2 mg kg−1 b.w. i.p. injection for 4 weeks | Nephrotoxicity, metabolic alterations, lipids, amino acids, and purine metabolism Decreased body and testicular weight, pathological changes in testes, oxidative stress, autophagy | Wang et al., 2020 [135] Guan et al., 2021 [137] | |
Goat sperm | 10 μM for up to 12 h at 38.5 °C | 60 μM for up to 12 h at 38.5 °C | Oxidative stress, sperm motility, survival rates, membrane integrity, mitochondrial activity, altered embryo development | Mao et al., 2018 [138] | |
Mice | 20–100 mg kg−1 b.w. day−1 for 1 week | 1.2 mg kg−1 b.w. day−1 for 1 week | Memory impairment of the F1-F2 generation, brain activity, expression of GST and CAT, Cd uptake | Halder et al., 2019 [139] | |
Hesperetin | Rat | 40 mg kg−1 b.w. by oral administration | 3 mg kg−1 by s.c. injection for 21 days | Acetylcholinesterase, ROS, protein carbonylation, SOD, CAT and DPx, GSH, vitamin C, total sulfhydryl groups, apoptotic markers, mitochondrial dysfunction | Shagirtha et al., 2016 [142] |
Anthocyanins | Rat | 10 mg kg−1 b.w. by stomach tube for 30 days | 4 μg kg−1 b.w. by stomach tube for 30 days | Cd accumulation in the liver and kidney | Kowalczyk et al., 2003 [145] |
Mice | 500 mg kg−1 day−1 for up to 30 days | 5 mg kg−1 day−1 for up to 30 days | Levels of gonadotropins, luteinizing hormone and follicle stimulating hormone, Gnrh1 gene expression | Li et al., 2019 [146] | |
Naringin | HepG2 cells | 5 μM for 24 h | 50 μM for 24 h | Alteration of antioxidant system, cytotoxicity, redox homeostasis, mitochondrial membrane potential, apoptosis, SOD, GST, CAT activities, lipid peroxidation | Rathi et al., 2017 [148] |
Human lymphocytes | 1–2 mg mL−1 for 24 h | 20 and 40 μM for 24 h | Chromosomal aberrations, ROS, antioxidant metabolism | Yılmaz et al., 2012 [149] | |
Curcumin | Mice | 0.14 mM kg−1 b.w. by gavage for 3 days, or 100 mg kg−1 b.w. by single i.p. injection | 33 μM kg−1 or 5 mg kg−1 b.w. by s.c. injection 1 or 24 h after curcumin treatment | Antioxidant enzymes activity, levels of total glutathione and thiol, MDA, H2O2, | Eybl et al., 2006 [151], Momeni et al., 2020 [152] |
Carvacrol | PC12 cells | 100 μM for 48 h | 10 μM for 48 h | Growth retardation, glutathione and glutathione reductase, caspase 3, cytochrome c, apoptosis inducing factor, mTOR, protein kinase B, nuclear factor kappa-light-chain-enhancer of activated B cells, extracellular signal-regulated kinase-1, nuclear factor erythroid 2-related factor 2 | Banik et al., 2019 [154] |
Ferulic acid | Rat | 50 mg kg−1 b.w. orally administered for 15 or 30 days | 10 mg kg−1 b.w. for 15 and 30 days by s.c. injection | Body weight and serum total protein contents, histopathological damage, AST, ALT, ALP and LDH, uric acid, urea, urea nitrogen, and creatinine content), lipid hydroperoxides, MDA, protein carbonyl content, total oxidant status, and oxidative stress index, total thiols, total antioxidant concentration, SOD, CAT, and GPx, GSH and total free sulfhydryl groups, TNF-α, COX-2, and HSP70 proteins | Sanjeev et al., 2019 [155] |
Vanillic acid | Oryza sativa L. | 50 μM seedlings exposure for 72 h | 1 and 2 mM seedlings exposure for 72 h | Photosynthetic pigment, osmotic status, biomass accumulation, growth, ROS, ascorbate pool size, antioxidant, and glyoxalase systems, phytochelatin content | Bhuyan et al., 2020 [159] |
Salicylic acid | Solanum tuberosum L. | 600 μM foliar spray exposure for 10 days | 200 μM foliar spray exposure for 10 days | RWC, antioxidant enzymatic mechanism pathway, chlorophyll, proline content, MDA, H2O2, and superoxide anion radicals | Li et al., 2019 [161] |
Abscisic acid | Lactuca sativa L. | 10 μg L−1 sprayed on leaves | 100 μM in hydroponic nutrient solution | Oxidative stress, H2O2, MDA, photosynthesis, mineral nutrients content, plant biomass | Dawuda et al., 2020 [163] |
Melatonin | Brassica napus L. Malva parviflora L. | 15, 50 or 100 µM in the nutrition solution | 25 µM for 5 days and 50 µM for 8 days | Photosynthesis, SOD, CAT, peroxidase, ascorbate peroxidase, proline, chlorophyll and anthocyanin content, MDA, H2O2 | Sami et al., 2020 [165], Tousi et al., 2020 [166] |
Malus domestica L. | 100 µM for up to 20 days | 30 µM for up to 20 days | Cd translocation, antioxidant enzymes activity, root Cd uptake, and leaf Cd accumulation | He et al., 2020 [167] | |
Brassica rapa subs. pekinensis | 100 µM sprayed of leaves once a day | 20 µM in the nutrient solution for 8 days | Nitric oxide, expression of the transporter gene IRT1, Cd absorption | Ni et al., 2018 [168] | |
Catharanthus roseus (L.) G. Don | 100 μM foliar spray | 50, 100, 200 mg kg−1 soil for 30 days | Phytoremediation efficiency, shoot biomass and chlorophyll content, POD and CAT activities, electrolyte leakage | Nabaei and Amooaghaie 2020 [170] | |
Solanum lycopersicum L. | 100 μM foliar spray for 15 days every 5th day | 100 μM for 15 days | Sulfur metabolism, caffeic acid O-methyltransferase (COMT) gene | Hasan et al., 2019 [171] | |
Mushrooms | 50, 100, or 200 μM in the growth medium for 5 days | 2, 5, and 8 μM in the growth medium for 5 days | Amino acid and glutathione metabolism, oxidation-reduction processes, metal, and ROS | Gao et al., 2020 [172] | |
Mice | 25 mg kg−1 for 14 days by i.p. injection | 5 mg kg−1 for 14 days by i.p. injection | Ovulation dysfunction and ovarian injury, pathohistological damage | Yang et al., 2019 [173] | |
Mice | 10 mg kg−1 by i.p. injection for 3 days before Cd administration | 2 mg kg−1 by single i.p. injection | Hepatocellular damage, ALT/AST enzymes, antioxidant activity, thioredoxin-interacting protein, TXNIP-NLRP3 inflammasome pathway | Cao et al., 2017 [177] | |
Ovarian cancer cells | 1 μM for 48 h in growth medium | 1–100 nM for 48 h in growth medium | Estradiol (E2)-derived proliferation | Ataei et al., 2018 [174] | |
Rat | 3 mg L−1 in drinking water for 1 month | 50 mg L−1 in drinking water for 1 month | Mineral and organic components, Ca2+ level, bone damage and histological alterations | Knani et al., 2019 [175] | |
Rat | 4 mg kg−1 30 min prior to Cd administration | 1 mg kg−1 by i.p. injection for 8 weeks | Memory and learning disabilities, NO and lipid peroxidation, CAT and SOD, Cd-induced neuronal loss | Lamtai et al., 2021 [176] | |
Human adipose cells | 10 nmol L−1–50 μmol L−1 in growth medium for 4 to 72 h | 0.25 to 10 μmol L−1 in growth medium for 4 to 72 h | Osteogenic differentiation properties, adipogenic differentiation | Knani et al., 2019 [175] | |
Fulvic acid | Lactuca sativa L. | 0.5 g L−1 in hydroponics for 2 weeks | 20 μM in hydroponics for 2 weeks | Nutrient elemental imbalance, pigment content, photosynthesis, photosystem PSII, ROS, antioxidant capacity | Wang et al., 2019 [181] |
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Požgajová, M.; Navrátilová, A.; Kovár, M. Curative Potential of Substances with Bioactive Properties to Alleviate Cd Toxicity: A Review. Int. J. Environ. Res. Public Health 2022, 19, 12380. https://doi.org/10.3390/ijerph191912380
Požgajová M, Navrátilová A, Kovár M. Curative Potential of Substances with Bioactive Properties to Alleviate Cd Toxicity: A Review. International Journal of Environmental Research and Public Health. 2022; 19(19):12380. https://doi.org/10.3390/ijerph191912380
Chicago/Turabian StylePožgajová, Miroslava, Alica Navrátilová, and Marek Kovár. 2022. "Curative Potential of Substances with Bioactive Properties to Alleviate Cd Toxicity: A Review" International Journal of Environmental Research and Public Health 19, no. 19: 12380. https://doi.org/10.3390/ijerph191912380