Possible Association of Hysterectomy Accompanied with Opportunistic Salpingectomy with Early Menopause: A Retrospective Cohort Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Data Sources
2.2. Study Design and Participants
2.3. Outcome Measures
2.4. Statistical Analysis
3. Results
3.1. Demography
3.2. Menopause Characteristics of the Patients
3.3. Onset Time of Menopause after Surgery
3.4. Subgroup Analysis
3.5. Analysis after Adjusting Covariates
4. Discussion
4.1. The Association between Hysterectomy, OS, and Ovarian Function
4.2. Population Study Regarding OS and Ovarian Functions
4.3. Systemic Review Regarding OS and Ovarian Cancer Prevention
4.4. The Age Effect on the Association between OS and Ovarian Function
4.5. BMI Effect on the Association between OS and Ovarian Functions
4.6. The Trends of OS
4.7. Strength and Limitation of the Study
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Item | Surgery | Total | p-Value | ||
---|---|---|---|---|---|
OS | Non-OS | ||||
N | 54 | 25 | 79 | ||
Age at the time of surgery | 45.52 ± 3.2 | 45.76 ± 3.47 | 45.59 ± 3.26 | 0.769 | |
Age group | 0.462 | ||||
<40 y/o | 4 (7.4%) | 1 (4%) | 5 (6.3%) | ||
40–44 y/o | 9 (16.7%) | 7 (28%) | 16 (20.3%) | ||
45–50 y/o | 41 (75.9%) | 17 (68%) | 58 (73.4%) | ||
BMI (kg/m2) | 25.27 ± 4.17 | 22.97 ± 3.27 | 24.54 ± 4.03 | 0.01 * | |
BMI group | 0.041 * | ||||
Underweight | 1 (1.9%) | 1 (4%) | 2 (2.5%) | ||
Normal | 22 (40.7%) | 18 (72%) | 40 (50.6%) | ||
Overweight | 14 (25.9%) | 4 (16%) | 18 (22.8%) | ||
Obese | 17 (31.5%) | 2 (8%) | 19 (24.1%) | ||
Parity | 2.26 ± 1.09 | 2.24 ± 1.23 | 2.25 ± 1.13 | 0.947 | |
HTN | 3 (5.6%) | 1 (4%) | 4 (5.1%) | 0.623 | |
DM | 1 (1.9%) | 2 (8%) | 3 (3.8%) | 0.234 | |
Approach | 0.279 | ||||
Laparoscopic | 31 (57.4%) | 12 (48%) | 43 (54.4%) | ||
Abdominal/open | 23 (42.6%) | 12 (48%) | 35 (44.3%) | ||
Vaginal | 0 (0%) | 1 (4%) | 1 (1.3%) | ||
Indication | 0.513 | ||||
Leiomyoma | 28 (51.9%) | 16 (64%) | 44 (55.7%) | ||
Endometriosis | 25 (46.3%) | 9 (36%) | 34 (43%) | ||
Prolapse | 1 (1.9%) | 0 (0%) | 1 (1.3%) | ||
HT use | 39 (72.2%) | 19 (76%) | 58 (73.4%) | 0.724 |
Item | Surgery | Total | p-Value | ||
---|---|---|---|---|---|
OS | Non-OS | ||||
HT use | 39 (72.2%) | 19 (76%) | 58 (73.4%) | 0.724 | |
Menopause symptoms | |||||
Hot flush | 21 (38.9%) | 12 (57.1%) | 33 (44%) | 0.153 | |
Night sweats | 12 (22.6%) | 5 (25%) | 17 (23.3%) | 0.529 | |
Sleep problems | 7 (13%) | 9 (41%) | 16 (21.1%) | 0.01 * | |
Mood changes | 4 (7.5%) | 0 (0%) | 4 (5.6%) | 0.285 | |
Dryness | 6 (11.3%) | 3 (15.8%) | 9 (12.5%) | 0.440 | |
Dysuria | 3 (5.6%) | 0 (0%) | 3 (4.1%) | 0.399 | |
Recurrent UTI | 0 (0%) | 0 (0%) | 0 (0%) | 1 | |
Sexual dysfunction | 7 (13%) | 1 (5.3%) | 8 (11%) | 0.328 |
Item | Surgery | Total | p-Value | |
---|---|---|---|---|
OS (n = 54) | Non-OS (n = 25) | |||
N | 54 | 25 | 79 | |
Age at surgery | 45.52 ± 3.2 | 45.76 ± 3.47 | 45.59 ± 3.26 | 0.769 |
Age at menopause | 47.36 ± 3.9 | 48.69 ± 3.96 | 47.78 ± 3.94 | 0.165 |
Surgery to menopause time (years) | 1.84 ± 1.85 | 2.93 ± 2.43 | 2.18 ± 2.09 | 0.031 * |
Age Group | Item | Surgery | Total | p-Value | |
---|---|---|---|---|---|
OS (n = 54) | Non-OS (n = 25) | ||||
<40 y/o (n = 5) | Surgery to menopause time (years) | 0.44 ± 0.40 | 4.60 ± NA | 1.27 ± 1.89 | NA |
(n = 4) | (n = 1) | ||||
40–44 y/o (n = 16) | 0.80 ± 0.75 | 2.86 ± 2.71 | 1.60 ± 2.09 | 0.094 | |
(n = 9) | (n = 7) | ||||
45–50 y/o (n = 58) | 2.21 ± 1.95 | 2.86 ± 2.42 | 2.40 ± 2.10 | 0.286 | |
(n = 41) | (n = 17) |
Item | Crude | Adjusted | ||
---|---|---|---|---|
β (95% CI) | p-Value | β (95% CI) | p-Value | |
Age at surgery | 0.02 (−0.12, 0.17) | 0.747 | 0.02 (−0.13, 0.16) | 0.814 |
BMI | 0.00 (−0.12, 0.12) | 0.998 | 0.04 (−0.09, 0.16) | 0.563 |
Parity | 0.04 (−0.38, 0.46) | 0.844 | 0.04 (−0.38, 0.46) | 0.856 |
Surgery (OS vs. non-OS) | −1.09 (−2.07, −0.1) | 0.031 * | −1.16 (−2.21, −0.12) | 0.029 * |
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Chen, P.-C.; Li, P.-C.; Ding, D.-C. Possible Association of Hysterectomy Accompanied with Opportunistic Salpingectomy with Early Menopause: A Retrospective Cohort Study. Int. J. Environ. Res. Public Health 2022, 19, 11871. https://doi.org/10.3390/ijerph191911871
Chen P-C, Li P-C, Ding D-C. Possible Association of Hysterectomy Accompanied with Opportunistic Salpingectomy with Early Menopause: A Retrospective Cohort Study. International Journal of Environmental Research and Public Health. 2022; 19(19):11871. https://doi.org/10.3390/ijerph191911871
Chicago/Turabian StyleChen, Pei-Chen, Pei-Chen Li, and Dah-Ching Ding. 2022. "Possible Association of Hysterectomy Accompanied with Opportunistic Salpingectomy with Early Menopause: A Retrospective Cohort Study" International Journal of Environmental Research and Public Health 19, no. 19: 11871. https://doi.org/10.3390/ijerph191911871