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Review

The Challenges of Treating Glucokinase MODY during Pregnancy: A Review of Maternal and Fetal Outcomes

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Diabetes, Endocrinology and Metabolic Disease Institute, Kaplan Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Rehovot 9190401, Israel
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Department of Medicine, Kaplan Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Rehovot 9190401, Israel
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Department of Obstetrics and Gynecology, Kaplan Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Rehovot 9190401, Israel
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Magee-Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
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Department of Obstetrics, Gynecology and Reproductive Science, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Int. J. Environ. Res. Public Health 2022, 19(10), 5980; https://doi.org/10.3390/ijerph19105980
Received: 30 April 2022 / Revised: 10 May 2022 / Accepted: 12 May 2022 / Published: 14 May 2022
(This article belongs to the Section Women's Health)
Background: The optimal treatment strategy for the follow-up and management of women with glucokinase maturity-onset diabetes of the young (GCK−MODY)during pregnancy remains unknown. Data regarding maternal and fetal outcomes are lacking. Aim: This paper summarizes the existing literature regarding the maternal and fetal outcomes of women with glucokinase MODY to guide future treatment strategy. Methods: A literature search was conducted in Pubmed, Embace, and Cochrane library with citation follow-up using the terms: glucokinase, MODY, diabetes, pregnancy, gestation, and outcomes. We searched for articles with known fetal mutational status. Relevant outcomes included: birthweight, large for gestational age (LGA), small for gestational age (SGA), macrosomia, cesarean delivery (CD), shoulder dystocia, congenital anomalies, miscarriages, preterm births, and long-term outcomes. Results: Fourteen relevant manuscripts were identified describing maternal and fetal outcomes. The percentage of LGA and macrosomia in 102 glucokinase -unaffected offspring (GCK−) was significantly higher than in the glucokinase -affected offspring (GCK+) (44% vs. 10%, p < 0.001 and 22% vs. 2%, p < 0.001, respectively). Among the 173 GCK(+) offspring, only 5% were SGA, which can be expected according to the normal distribution. We observed higher rates of CD and shoulder dystocia in the GCK(−) offspring. Conclusions: GCK(−) offspring have significantly higher birthweights and more birth complications. The optimal treatment strategy to guide management should take into consideration multiple variables other than fetal mutational status. View Full-Text
Keywords: diabetes; glucokinase; MODY; MODY 2; pregnancy diabetes; glucokinase; MODY; MODY 2; pregnancy
MDPI and ACS Style

Kirzhner, A.; Barak, O.; Vaisbuch, E.; Zornitzki, T.; Schiller, T. The Challenges of Treating Glucokinase MODY during Pregnancy: A Review of Maternal and Fetal Outcomes. Int. J. Environ. Res. Public Health 2022, 19, 5980. https://doi.org/10.3390/ijerph19105980

AMA Style

Kirzhner A, Barak O, Vaisbuch E, Zornitzki T, Schiller T. The Challenges of Treating Glucokinase MODY during Pregnancy: A Review of Maternal and Fetal Outcomes. International Journal of Environmental Research and Public Health. 2022; 19(10):5980. https://doi.org/10.3390/ijerph19105980

Chicago/Turabian Style

Kirzhner, Alena, Oren Barak, Edi Vaisbuch, Taiba Zornitzki, and Tal Schiller. 2022. "The Challenges of Treating Glucokinase MODY during Pregnancy: A Review of Maternal and Fetal Outcomes" International Journal of Environmental Research and Public Health 19, no. 10: 5980. https://doi.org/10.3390/ijerph19105980

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