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Perspective

Persistence as a Robust Indicator of Medication Adherence-Related Quality and Performance

by
Enrica Menditto
1,*,†,
Caitriona Cahir
2,†,
Sara Malo
3,
Isabel Aguilar-Palacio
3,
Marta Almada
4,
Elisio Costa
4,
Anna Giardini
5,
María Gil Peinado
6,
Mireia Massot Mesquida
7,
Sara Mucherino
1,
Valentina Orlando
1,
Carlos Luis Parra-Calderón
8,
Enrique Pepiol Salom
9,
Przemyslaw Kardas
10 and
Bernard Vrijens
11
1
CIRFF, Center of Pharmacoeconomics and Drug Utilization Research, Department of Pharmacy, University of Naples Federico II, 80131 Naples, Italy
2
Data Science Centre, Royal College of Surgeons in Ireland, D02 YN77 Dublin, Ireland
3
Preventive Medicine and Public Health Department, Zaragoza University, Fundación Instituto de Investigación Sanitaria de Aragón (IIS Aragón), 50009 Zaragoza, Spain
4
UCIBIO/REQUIMTE, Competences Centre on Active and Healthy Ageing of the University of Porto, Porto4Ageing, Faculty of Pharmacy, University of Porto, 4099-002 Porto, Portugal
5
IT Department, Istituti Clinici Scientifici Maugeri IRCCS Pavia, Pavia 27100, Italy
6
Drug Information Centre and Pharmaceutical Care Department, Muy Ilustre Colegio Oficial de Farmacéuticos de Valencia (MICOF Valencia), 46003 Valencia, Spain
7
Servei d’Atenció Primària Vallès Occidental, Institut Català de la Salut, 08202 Barcelona, Spain
8
Group of Research and Innovation in Biomedical Informatics, Biomedical Engineering and Health Economy, Institute of Biomedicine of Seville, IBiS/Virgen del Rocío University Hospital/CSIC/University of Seville, 41004 Sevilla, Spain
9
International Committee, Muy Ilustre Colegio Oficial de Farmacéuticos de Valencia (MICOF Valencia), 46003 Valencia, Spain
10
Medication Adherence Research Centre, Medical University of Lodz, 90-136 Lodz, Poland
11
AARDEX Group & Liège University, 4000 Liège, Belgium
 
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*
Author to whom correspondence should be addressed.
†
These authors contributed equally.
Int. J. Environ. Res. Public Health 2021, 18(9), 4872; https://doi.org/10.3390/ijerph18094872
Submission received: 9 April 2021 / Revised: 29 April 2021 / Accepted: 30 April 2021 / Published: 3 May 2021
(This article belongs to the Special Issue Optimising Drug Prescribing and Improving Medication Management: What Can We Do?)
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Abstract

Medication adherence is a priority for health systems worldwide and is widely recognised as a key component of quality of care for disease management. Adherence-related indicators were rarely explicitly included in national health policy agendas. One barrier is the lack of standardised adherence terminology and of routine measures of adherence in clinical practice. This paper discusses the possibility of developing adherence-related performance indicators highlighting the value of measuring persistence as a robust indicator of quality of care. To standardise adherence and persistence-related terminology allowing for benchmarking of adherence strategies, the European Ascertaining Barriers for Compliance (ABC) project proposed a Taxonomy of Adherence in 2012 consisting of three components: initiation, implementation, discontinuation. Persistence, which immediately precedes discontinuation, is a key element of taxonomy, which could capture adherence chronology allowing the examination of patterns of medication-taking behaviour. Advances in eHealth and Information Communication Technology (ICT) could play a major role in providing necessary structures to develop persistence indicators. We propose measuring persistence as an informative and pragmatic measure of medication-taking behaviour. Our view is to develop quality and performance indicators of persistence, which requires investing in ICT solutions enabling healthcare providers to review complete information on patients’ medication-taking patterns, as well as clinical and health outcomes.
Keywords: medication adherence; persistence; quality of care; performance indicator; electronic health records medication adherence; persistence; quality of care; performance indicator; electronic health records

Share and Cite

MDPI and ACS Style

Menditto, E.; Cahir, C.; Malo, S.; Aguilar-Palacio, I.; Almada, M.; Costa, E.; Giardini, A.; Gil Peinado, M.; Massot Mesquida, M.; Mucherino, S.; et al. Persistence as a Robust Indicator of Medication Adherence-Related Quality and Performance. Int. J. Environ. Res. Public Health 2021, 18, 4872. https://doi.org/10.3390/ijerph18094872

AMA Style

Menditto E, Cahir C, Malo S, Aguilar-Palacio I, Almada M, Costa E, Giardini A, Gil Peinado M, Massot Mesquida M, Mucherino S, et al. Persistence as a Robust Indicator of Medication Adherence-Related Quality and Performance. International Journal of Environmental Research and Public Health. 2021; 18(9):4872. https://doi.org/10.3390/ijerph18094872

Chicago/Turabian Style

Menditto, Enrica, Caitriona Cahir, Sara Malo, Isabel Aguilar-Palacio, Marta Almada, Elisio Costa, Anna Giardini, María Gil Peinado, Mireia Massot Mesquida, Sara Mucherino, and et al. 2021. "Persistence as a Robust Indicator of Medication Adherence-Related Quality and Performance" International Journal of Environmental Research and Public Health 18, no. 9: 4872. https://doi.org/10.3390/ijerph18094872

APA Style

Menditto, E., Cahir, C., Malo, S., Aguilar-Palacio, I., Almada, M., Costa, E., Giardini, A., Gil Peinado, M., Massot Mesquida, M., Mucherino, S., Orlando, V., Parra-Calderón, C. L., Pepiol Salom, E., Kardas, P., & Vrijens, B. (2021). Persistence as a Robust Indicator of Medication Adherence-Related Quality and Performance. International Journal of Environmental Research and Public Health, 18(9), 4872. https://doi.org/10.3390/ijerph18094872

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