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Article

The Relationship between HIV Duration, Insulin Resistance and Diabetes Risk

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Department of Physical Medicine and Rehabilitation, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
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Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
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Department of Family Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
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Department for Health, University of Bath, Bath BA2 7AY, UK
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Department of Psychiatry & Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
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Author to whom correspondence should be addressed.
Academic Editor: Stefano Ballestri
Int. J. Environ. Res. Public Health 2021, 18(8), 3926; https://doi.org/10.3390/ijerph18083926
Received: 11 February 2021 / Revised: 29 March 2021 / Accepted: 31 March 2021 / Published: 8 April 2021
(This article belongs to the Special Issue Exercise and Healthy Eating for Successful Aging with HIV)
The risk of developing Type 2 Diabetes Mellitus in people living with HIV (PLWH) can be four times greater and can occur at an earlier age and even without the presence of obesity compared to those without HIV. Therefore, the purpose of this analytical cross-sectional study was to determine the relationship between HIV duration and glucose metabolism among PLWH. Eighty-two PLWH were categorized into shorter (≤15 years) or longer HIV duration (≥16 years) and then compared for differences in demographics, physical and clinical characteristics, biomarkers, and dietary intake. Compared to those with shorter HIV duration (n = 34), those with longer HIV duration (n = 48) were on average older (p = 0.02), reported lower consumption of alcohol (p = 0.05), had higher levels of homeostasis model assessment of insulin resistance (HOMA-IR, p = 0.02), were also more likely to be a woman (p = 0.06), and have higher levels of fasting insulin (p = 0.06). When adjusted for age and body weight, the levels of HOMA-IR and fasting insulin were higher (p = 0.02 and p = 0.04) with longer compared to shorter HIV duration, respectively. Longer exposure to HIV infection is associated with impaired insulin sensitivity. Continuing research aimed at the long-term effects of HIV infection and (antiretroviral therapy) is required. View Full-Text
Keywords: HIV infection; duration; HOMA-IR; insulin resistance; type 2 diabetes HIV infection; duration; HOMA-IR; insulin resistance; type 2 diabetes
MDPI and ACS Style

Tiozzo, E.; Rodriguez, A.; Konefal, J.; Farkas, G.J.; Maher, J.L.; Lewis, J.E. The Relationship between HIV Duration, Insulin Resistance and Diabetes Risk. Int. J. Environ. Res. Public Health 2021, 18, 3926. https://doi.org/10.3390/ijerph18083926

AMA Style

Tiozzo E, Rodriguez A, Konefal J, Farkas GJ, Maher JL, Lewis JE. The Relationship between HIV Duration, Insulin Resistance and Diabetes Risk. International Journal of Environmental Research and Public Health. 2021; 18(8):3926. https://doi.org/10.3390/ijerph18083926

Chicago/Turabian Style

Tiozzo, Eduard; Rodriguez, Allan; Konefal, Janet; Farkas, Gary J.; Maher, Jennifer L.; Lewis, John E. 2021. "The Relationship between HIV Duration, Insulin Resistance and Diabetes Risk" Int. J. Environ. Res. Public Health 18, no. 8: 3926. https://doi.org/10.3390/ijerph18083926

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Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

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