Next Article in Journal
The Effect of a Non-Invasive Positive Pressure Ventilation Simulation Program on General Ward Nurses’ Knowledge and Self-Efficacy
Previous Article in Journal
A Model for the Implementation of Lean Improvements in Healthcare Environments as Applied in a Primary Care Center
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJERPH
Volume 18
Issue 6
10.3390/ijerph18062862
ijerph-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

The Relationship between Long Noncoding RNA H19 Polymorphism and the Epidermal Growth Factor Receptor Phenotypes on the Clinicopathological Characteristics of Lung Adenocarcinoma

by
Yao-Chen Wang
1,2,
Shih-Ming Tsao
1,3,
Yia-Ting Li
4,5,
Chia-Yi Lee
6,
Thomas Chang-Yao Tsao
1,3,
Ming-Ju Hsieh
5,7,8,* and
Shun-Fa Yang
5,9,*
1
School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
2
Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan
3
Division of Chest, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan
4
Division of Respiratory Therapy, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan
5
Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
6
Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua 500, Taiwan
7
Oral Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan
8
Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404, Taiwan
9
Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan
*
Authors to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2021, 18(6), 2862; https://doi.org/10.3390/ijerph18062862
Submission received: 30 December 2020 / Revised: 9 March 2021 / Accepted: 10 March 2021 / Published: 11 March 2021
Versions Notes

Abstract

The aim of the current study is to investigate potential associations among Long Noncoding RNA (LncRNA) H19 single nucleotide polymorphism (SNP) and epidermal growth factor receptor (EGFR) phenotypes on the clinicopathological characteristics of lung adenocarcinoma (LADC). Five loci of LncRNA H19 SNPs (rs217727, rs2107425, rs2839698, rs3024270, and rs3741219) were genotyped by using TaqMan allelic discrimination in 223 LADC patients with wild-type EGFR phenotype and 323 LADC individuals with EGFR mutations. After the statistical analyses, patients with the EGFR mutation were related to a higher distribution frequency of rs217727 SNP CT heterozygote (p = 0.030), and the female population with EGFR mutation demonstrated a higher distribution frequency of rs217727 SNP CT heterozygote (p < 0.001) and rs2107425 CT heterozygote (p = 0.002). In addition, the presence of LncRNA H19 SNP rs217727 T allele (CT + TT) in patients with EGFR wild-type was associated to higher tumor T status (stage III or IV, p = 0.037) and poorer cell differentiation status (poor differentiation, p = 0.012) compared to those EGFR wild-type individuals with LncRNA H19 SNP rs217727 CC allele. Besides, a prominently higher tumor T status was found in subjects with LncRNA H19 SNP rs2107425 T allele (CT + TT) (stage III or IV, p = 0.007) compared to EGFR wild-type LADC individuals with LncRNA CC allele in EGFR wild-type patients. Our findings suggest that the presence of LncRNA H19 SNP rs217727 is related to the EGFR mutation in LADC patients, and the LncRNA H19 SNP rs217727 and rs2107425 are associated with progressed tumor status for LADC patients with EGFR wild-type.
Keywords: long noncoding RNA H19; epithelial growth factor receptor; lung adenocarcinoma; single nucleotide polymorphism; tumor status long noncoding RNA H19; epithelial growth factor receptor; lung adenocarcinoma; single nucleotide polymorphism; tumor status

Share and Cite

MDPI and ACS Style

Wang, Y.-C.; Tsao, S.-M.; Li, Y.-T.; Lee, C.-Y.; Tsao, T.C.-Y.; Hsieh, M.-J.; Yang, S.-F. The Relationship between Long Noncoding RNA H19 Polymorphism and the Epidermal Growth Factor Receptor Phenotypes on the Clinicopathological Characteristics of Lung Adenocarcinoma. Int. J. Environ. Res. Public Health 2021, 18, 2862. https://doi.org/10.3390/ijerph18062862

AMA Style

Wang Y-C, Tsao S-M, Li Y-T, Lee C-Y, Tsao TC-Y, Hsieh M-J, Yang S-F. The Relationship between Long Noncoding RNA H19 Polymorphism and the Epidermal Growth Factor Receptor Phenotypes on the Clinicopathological Characteristics of Lung Adenocarcinoma. International Journal of Environmental Research and Public Health. 2021; 18(6):2862. https://doi.org/10.3390/ijerph18062862

Chicago/Turabian Style

Wang, Yao-Chen, Shih-Ming Tsao, Yia-Ting Li, Chia-Yi Lee, Thomas Chang-Yao Tsao, Ming-Ju Hsieh, and Shun-Fa Yang. 2021. "The Relationship between Long Noncoding RNA H19 Polymorphism and the Epidermal Growth Factor Receptor Phenotypes on the Clinicopathological Characteristics of Lung Adenocarcinoma" International Journal of Environmental Research and Public Health 18, no. 6: 2862. https://doi.org/10.3390/ijerph18062862

APA Style

Wang, Y.-C., Tsao, S.-M., Li, Y.-T., Lee, C.-Y., Tsao, T. C.-Y., Hsieh, M.-J., & Yang, S.-F. (2021). The Relationship between Long Noncoding RNA H19 Polymorphism and the Epidermal Growth Factor Receptor Phenotypes on the Clinicopathological Characteristics of Lung Adenocarcinoma. International Journal of Environmental Research and Public Health, 18(6), 2862. https://doi.org/10.3390/ijerph18062862

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop