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Systematic Review

Effect of Chronic Resistance Training on Circulating Irisin: Systematic Review and Meta-Analysis of Randomized Controlled Trials

1
Faculty of Health Sciences, Universidad Europea del Atlántico, 39011 Santander, Spain
2
National Institute of Physical Education and Sport of Catalonia (INEFC), University of Barcelona, 08038 Barcelona, Spain
*
Author to whom correspondence should be addressed.
Academic Editors: Anna Prats-Puig and Sergi Garcia-Retortillo
Int. J. Environ. Res. Public Health 2021, 18(5), 2476; https://doi.org/10.3390/ijerph18052476
Received: 20 January 2021 / Revised: 24 February 2021 / Accepted: 25 February 2021 / Published: 3 March 2021
(This article belongs to the Special Issue Tissue Crosstalk Adaptations to Physical Exercise)
Irisin seems to play an important role in several chronic diseases, however, the interactions between chronic training and irisin are still unclear. The purpose of this systematic review and meta-analysis was to examine the effect of chronic resistance training on circulating irisin in adults. Literature search was conducted in PubMed, Web of Science and EBSCOhost (Academic Search Complete) until December 2020. Randomized controlled trials researching irisin levels after a resistance training program for at least 8 weeks among an adult population were eligible. Other inclusion criteria comprised recruiting a control group and reporting circulating irisin through ELISA kits. Cohen’s d effect size and subgroup analyses (95% confidence level) were calculated using a random effects analysis model. Data of the seven included studies comprising 282 individuals showed an increasing and non-significant tendency after a resistance training program (d = 0.58, 95% CI: −0.25 to 1.40, p = 0.17). Subgroup analyses showed significant increases for the older adults group (p < 0.001) and when training is demanding and progressive in terms of intensity (p = 0.03). Data suggest that resistance training programs seem to increase circulating irisin, especially in older adults and in demanding and progressive training programs. However, more studies should be conducted using robust measurement methods, such as mass spectrometry, to better understand the interaction between chronic resistance exercise and irisin. View Full-Text
Keywords: exercise therapy; metabolic diseases; peptide hormones; immunoassay; muscle fibers exercise therapy; metabolic diseases; peptide hormones; immunoassay; muscle fibers
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MDPI and ACS Style

Cosio, P.L.; Crespo-Posadas, M.; Velarde-Sotres, Á.; Pelaez, M. Effect of Chronic Resistance Training on Circulating Irisin: Systematic Review and Meta-Analysis of Randomized Controlled Trials. Int. J. Environ. Res. Public Health 2021, 18, 2476. https://doi.org/10.3390/ijerph18052476

AMA Style

Cosio PL, Crespo-Posadas M, Velarde-Sotres Á, Pelaez M. Effect of Chronic Resistance Training on Circulating Irisin: Systematic Review and Meta-Analysis of Randomized Controlled Trials. International Journal of Environmental Research and Public Health. 2021; 18(5):2476. https://doi.org/10.3390/ijerph18052476

Chicago/Turabian Style

Cosio, Pedro L., Manuel Crespo-Posadas, Álvaro Velarde-Sotres, and Mireia Pelaez. 2021. "Effect of Chronic Resistance Training on Circulating Irisin: Systematic Review and Meta-Analysis of Randomized Controlled Trials" International Journal of Environmental Research and Public Health 18, no. 5: 2476. https://doi.org/10.3390/ijerph18052476

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