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Open AccessArticle

BST204 Protects Dexamethasone-Induced Myotube Atrophy through the Upregulation of Myotube Formation and Mitochondrial Function

1
Research Institute of Pharmaceutical Science, College of Pharmacy, Sookmyung Women’s University, Seoul 04310, Korea
2
Molecular Cell Biology, Single Cell Network Research Center, School of Medicine, Sungkyunkwan University, Suwon 16419, Korea
3
Green Cross Wellbeing Co., Ltd., Seongnam 13595, Korea
4
Research Institute of Aging-Related Disease, AniMusCure Inc., Suwon 16419, Korea
*
Authors to whom correspondence should be addressed.
Academic Editor: Oliver Grundmann
Int. J. Environ. Res. Public Health 2021, 18(5), 2367; https://doi.org/10.3390/ijerph18052367
Received: 14 January 2021 / Revised: 19 February 2021 / Accepted: 23 February 2021 / Published: 1 March 2021
(This article belongs to the Special Issue Toxicity of Medicinal Plants and Herbal Supplements)
BST204 is a purified ginseng dry extract that has an inhibitory effect on lipopolysaccharide-induced inflammatory responses, but its effect on muscle atrophy is yet to be investigated. In this study, C2C12 myoblasts were induced to differentiate for three days followed by the treatment of dexamethasone (DEX), a corticosteroid drug, with vehicle or BST204 for one day and subjected to immunoblotting, immunocytochemistry, qRT-PCR and biochemical analysis for mitochondrial function. BST204 alleviates the myotube atrophic effect mediated by DEX via the activation of protein kinase B/mammalian target of rapamycin (Akt/mTOR) signaling. Through this pathway, BST204 suppresses the expression of muscle-specific E3 ubiquitin ligases contributing to the enhanced myotube formation and enlarged myotube diameter in DEX-treated myotubes. In addition, BST204 treatment significantly decreases the mitochondrial reactive oxygen species production in DEX-treated myotubes. Furthermore, BST204 improves mitochondrial function by upregulating the expression of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC1α) in DEX-induced myotube atrophy. This study provides a mechanistic insight into the effect of BST204 on DEX-induced myotube atrophy, suggesting that BST204 has protective effects against the toxicity of a corticosteroid drug in muscle and promising potential as a nutraceutical remedy for the treatment of muscle weakness and atrophy. View Full-Text
Keywords: Akt/mTOR pathway; BST204; mitochondria; muscle atrophy; PGC1α Akt/mTOR pathway; BST204; mitochondria; muscle atrophy; PGC1α
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MDPI and ACS Style

Kim, R.; Kim, H.; Im, M.; Park, S.K.; Han, H.J.; An, S.; Kang, J.-S.; Lee, S.-J.; Bae, G.-U. BST204 Protects Dexamethasone-Induced Myotube Atrophy through the Upregulation of Myotube Formation and Mitochondrial Function. Int. J. Environ. Res. Public Health 2021, 18, 2367. https://doi.org/10.3390/ijerph18052367

AMA Style

Kim R, Kim H, Im M, Park SK, Han HJ, An S, Kang J-S, Lee S-J, Bae G-U. BST204 Protects Dexamethasone-Induced Myotube Atrophy through the Upregulation of Myotube Formation and Mitochondrial Function. International Journal of Environmental Research and Public Health. 2021; 18(5):2367. https://doi.org/10.3390/ijerph18052367

Chicago/Turabian Style

Kim, Ryuni; Kim, Hyebeen; Im, Minju; Park, Sun K.; Han, Hae J.; An, Subin; Kang, Jong-Sun; Lee, Sang-Jin; Bae, Gyu-Un. 2021. "BST204 Protects Dexamethasone-Induced Myotube Atrophy through the Upregulation of Myotube Formation and Mitochondrial Function" Int. J. Environ. Res. Public Health 18, no. 5: 2367. https://doi.org/10.3390/ijerph18052367

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