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Open AccessArticle

Regional Strain Pattern Index—A Novel Technique to Predict CRT Response

1
First Department of Cardiology, School of Medicine in Katowice, Medical University of Silesia, ul. Ziolowa 45/47, 40-635 Katowice, Poland
2
Department of Cardiology, Pomeranian Medical University, 70-204 Szczecin, Poland
*
Author to whom correspondence should be addressed.
Both authors contributed equally to this manuscript.
Int. J. Environ. Res. Public Health 2021, 18(3), 926; https://doi.org/10.3390/ijerph18030926
Received: 9 November 2020 / Revised: 15 January 2021 / Accepted: 16 January 2021 / Published: 21 January 2021
(This article belongs to the Special Issue Advances in Heart Electrotherapy)
Background: Cardiac resynchronization therapy (CRT) improves outcome in patients with heart failure (HF) however approximately 30% of patients still remain non-responsive. We propose a novel index—Regional Strain Pattern Index (RSPI)—to prospectively evaluate response to CRT. Methods: Echocardiography was performed in 49 patients with HF (66.5 ± 10 years, LVEF 24.9 ± 6.4%, QRS width 173.1 ± 19.1 ms) two times: before CRT implantation and 15 ± 7 months after. At baseline, dyssynchrony was assessed including RSPI and strain pattern. RSPI was calculated from all three apical views across 12 segments as the sum of dyssynchronous components. From every apical view, presence of four components were assessed: (1) contraction of the early-activated wall; (2) prestretching of the late activated wall; (3) contraction of the early-activated wall in the first 70% of the systolic ejection phase; (4) peak contraction of the late-activated wall after aortic valve closure. Each component scored 1 point, thus the maximum was 12 points. Results: Responders reached higher mean RSPI values than non-responders (5.86 ± 2.9 vs. 4.08 ± 2.4; p = 0.044). In logistic regression analysis value of RSPI ≥ 7 points was a predictor of favorable CRT effect (OR: 12; 95% CI = 1.33–108.17; p = 0.004). Conclusions: RSPI could be a valuable predictor of positive outcome in HF patients treated with CRT. View Full-Text
Keywords: cardiac resynchronization therapy; dyssynchrony; strain pattern; heart failure; RSPI cardiac resynchronization therapy; dyssynchrony; strain pattern; heart failure; RSPI
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MDPI and ACS Style

Orszulak, M.; Filipecki, A.; Wróbel, W.; Berger-Kucza, A.; Orszulak, W.; Urbańczyk-Swić, D.; Kwaśniewski, W.; Płońska-Gościniak, E.; Mizia-Stec, K. Regional Strain Pattern Index—A Novel Technique to Predict CRT Response. Int. J. Environ. Res. Public Health 2021, 18, 926. https://doi.org/10.3390/ijerph18030926

AMA Style

Orszulak M, Filipecki A, Wróbel W, Berger-Kucza A, Orszulak W, Urbańczyk-Swić D, Kwaśniewski W, Płońska-Gościniak E, Mizia-Stec K. Regional Strain Pattern Index—A Novel Technique to Predict CRT Response. International Journal of Environmental Research and Public Health. 2021; 18(3):926. https://doi.org/10.3390/ijerph18030926

Chicago/Turabian Style

Orszulak, Michał; Filipecki, Artur; Wróbel, Wojciech; Berger-Kucza, Adrianna; Orszulak, Witold; Urbańczyk-Swić, Dagmara; Kwaśniewski, Wojciech; Płońska-Gościniak, Edyta; Mizia-Stec, Katarzyna. 2021. "Regional Strain Pattern Index—A Novel Technique to Predict CRT Response" Int. J. Environ. Res. Public Health 18, no. 3: 926. https://doi.org/10.3390/ijerph18030926

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