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Article

Immunohistochemical Analysis of the Beclin-1 Expression Predicts the Progression of Oral Squamous Cell Carcinoma

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Unit of Maxillofacial Surgery, Department of Experimental and Clinical Medicine, “Magna Graecia” University, Viale Europa, 88100 Catanzaro, Italy
2
Pathology Unit, Department of Health Science, Medical School, Magna Græcia University of Catanzaro, Viale Europa, 88100 Catanzaro, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Int. J. Environ. Res. Public Health 2021, 18(21), 11125; https://doi.org/10.3390/ijerph182111125
Received: 16 August 2021 / Revised: 14 October 2021 / Accepted: 21 October 2021 / Published: 22 October 2021
Background: Autophagy is a cellular process responsible for maintaining homeostasis; a dysregulation of this process is involved in the development and progression of neoplasms. Beclin-1 is one of the major proteins linked to autophagy. However, the data regarding the association between the role of Beclin-1 and the progression of Oral Squamous Cell Carcinoma (OSCC) are rather low. For this reason, the objective of this study is to evaluate, through immunohistochemical techniques, the prognostic role of the expression of Beclin-1 autophagy marker in patients with OSCC. Methods: This is a single-centre retrospective study that includes patients with OSCC admitted to the Maxillofacial Unit of “Magna Graecia” University between January 2019 and September 2020. All the samples obtained from surgery were treated with anti Beclin-1 antibodies and subjected to immunohistochemical methods. Results: A total of 26 samples were analysed and the following variables were evaluated for each: percentage of positive Beclin-1 expression by tumour cells, signal strength of tumour cells, and total score. The variables considered were first normalised according to the D’Agostino and Pearson test, then analysed using the Pearson linear correlation coefficient: a statistically significant correlation was found between the parameters infiltration-intensity (p = 0.0088), infiltration-percent (p = 0.0123), intensity-total score (p = 0.0060). Conclusions: The immunohistochemical evaluation of Beclin-1 revealed a statistically significant correlation between the intensity of the molecule’s expression and a greater degree of infiltration of the neoplasm. Beclin-1 can, therefore, be considered a valid prognostic index of disease. View Full-Text
Keywords: Beclin-1; maxillofacial surgery; head and neck cancer; oral cancer; oncological surgery Beclin-1; maxillofacial surgery; head and neck cancer; oral cancer; oncological surgery
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MDPI and ACS Style

Barca, I.; Mignogna, C.; Novembre, D.; Ferragina, F.; Cristofaro, M.G. Immunohistochemical Analysis of the Beclin-1 Expression Predicts the Progression of Oral Squamous Cell Carcinoma. Int. J. Environ. Res. Public Health 2021, 18, 11125. https://doi.org/10.3390/ijerph182111125

AMA Style

Barca I, Mignogna C, Novembre D, Ferragina F, Cristofaro MG. Immunohistochemical Analysis of the Beclin-1 Expression Predicts the Progression of Oral Squamous Cell Carcinoma. International Journal of Environmental Research and Public Health. 2021; 18(21):11125. https://doi.org/10.3390/ijerph182111125

Chicago/Turabian Style

Barca, Ida, Chiara Mignogna, Daniela Novembre, Francesco Ferragina, and Maria G. Cristofaro 2021. "Immunohistochemical Analysis of the Beclin-1 Expression Predicts the Progression of Oral Squamous Cell Carcinoma" International Journal of Environmental Research and Public Health 18, no. 21: 11125. https://doi.org/10.3390/ijerph182111125

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