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Open AccessArticle

Neurodevelopmental Outcomes at 18 Months of Corrected Age for Late Preterm Infants Born at 34 and 35 Gestational Weeks

1
Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe 6500017, Japan
2
Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe 6500017, Japan
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2021, 18(2), 640; https://doi.org/10.3390/ijerph18020640
Received: 25 November 2020 / Revised: 7 January 2021 / Accepted: 9 January 2021 / Published: 13 January 2021
To date, the difference in neurodevelopmental outcomes between late preterm infants (LPI) born at 34 and 35 gestational weeks (LPI-34 and LPI-35, respectively) has not been elucidated. This retrospective study aimed to evaluate neurodevelopmental outcomes at 18 months of corrected age for LPI-34 and LPI-35, and to elucidate factors predicting neurodevelopmental impairment (NDI). Records of all LPI-34 (n = 93) and LPI-35 (n = 121) admitted to our facility from 2013 to 2017 were reviewed. Patients with congenital or chromosomal anomalies, severe neonatal asphyxia, and without developmental quotient (DQ) data were excluded. Psychomotor development was assessed as a DQ using the Kyoto Scale of Psychological Development at 18 months of corrected age. NDI was defined as DQ < 80 or when severe neurodevelopmental problems made neurodevelopmental assessment impossible. We compared the clinical characteristics and DQ values between LPI-34 (n = 62) and LPI-35 (n = 73). To elucidate the factors predicting NDI at 18 months of corrected age, we compared clinical factors between the NDI (n = 17) and non-NDI (n = 118) groups. No significant difference was observed in DQ values at 18 months of corrected age between the groups in each area and overall. Among clinical factors, male sex, intraventricular hemorrhage (IVH), hyperbilirubinemia, and severe hyperbilirubinemia had a higher prevalence in the NDI group than in the non-NDI group, and IVH and/or severe hyperbilirubinemia showed the highest Youden Index values for predicting NDI. Based on the results of this study, we can conclude that no significant difference in neurodevelopmental outcomes at 18 months of corrected age was observed between LPI-34 and LPI-35. Patients with severe hyperbilirubinemia and/or IVH should be considered to be at high risk for developing NDI. View Full-Text
Keywords: late preterm infants; neurodevelopmental outcome; neurodevelopmental impairment late preterm infants; neurodevelopmental outcome; neurodevelopmental impairment
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MDPI and ACS Style

Nakasone, R.; Fujioka, K.; Kyono, Y.; Yoshida, A.; Kido, T.; Suga, S.; Abe, S.; Ashina, M.; Nishida, K.; Tanimura, K.; Yamada, H.; Nozu, K.; Iijima, K. Neurodevelopmental Outcomes at 18 Months of Corrected Age for Late Preterm Infants Born at 34 and 35 Gestational Weeks. Int. J. Environ. Res. Public Health 2021, 18, 640.

AMA Style

Nakasone R, Fujioka K, Kyono Y, Yoshida A, Kido T, Suga S, Abe S, Ashina M, Nishida K, Tanimura K, Yamada H, Nozu K, Iijima K. Neurodevelopmental Outcomes at 18 Months of Corrected Age for Late Preterm Infants Born at 34 and 35 Gestational Weeks. International Journal of Environmental Research and Public Health. 2021; 18(2):640.

Chicago/Turabian Style

Nakasone, Ruka; Fujioka, Kazumichi; Kyono, Yuki; Yoshida, Asumi; Kido, Takumi; Suga, Shutaro; Abe, Shinya; Ashina, Mariko; Nishida, Kosuke; Tanimura, Kenji; Yamada, Hideto; Nozu, Kandai; Iijima, Kazumoto. 2021. "Neurodevelopmental Outcomes at 18 Months of Corrected Age for Late Preterm Infants Born at 34 and 35 Gestational Weeks" Int. J. Environ. Res. Public Health 18, no. 2: 640.

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